Long-term potentiation differentially affects two components of synaptic responses in hippocampus.
Open accessAbstract
We have used low magnesium concentrations and the specific antagonist D-2-amino-5-phosphonopentanoate (D-AP5) to estimate the effects of long-term potentiation (LTP) on the N-methyl-D-aspartate (NMDA) and non-NMDA receptor-mediated components of postsynaptic responses. LTP induction resulted in a considerably larger potentiation of non-NMDA as opposed to NMDA receptor-related currents. Increasing the size of postsynaptic potentials with greater stimulation currents or with paired-pulse facilitation produced opposite effects; i.e., those aspects of the response dependent on NMDA receptors increased to a greater degree than did those components mediated by non-NMDA receptors. These results pose new constraints on hypotheses about the locus and nature of LTP and strongly suggest that postsynaptic modifications are part of the effect.
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The AMPA, but not NMDA, component of EPSPs is affected by LTP.
“Consistently, the AMPA, but not NMDA, component of EPSPs is affected by LTP404142.”
From State-dependent diffusion of actin-depolymerizing factor/cofilin underlies the enlargement and shrinkage of dendritic spines (2016) · cites this paper as [41]
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Self-citation
- Authors
- Muller, D., & Lynch, G.
- Affiliations
- University of California, Irvine (US)
- ORCID
- Lynch, G
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1988-12
- Volume
- 85
- Issue
- 23
- Pages
- 9346-9350
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC282736
- OpenAlex
- W2046289242
- Cited by
- 207
- References
- 0
- Citations by year
- 2026: 1 · 2025: 1 · 2024: 4 · 2023: 2 · 2022: 1 · 2021: 2 · 2019: 4 · 2017: 3 · 2016: 4 · 2014: 1 · 2013: 7 · 2012: 2
- FWCI
- 6.75
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Keywords
- long-term potentiation, hippocampus, NMDA receptor, non-NMDA receptors, postsynaptic potentials, paired-pulse facilitation, low magnesium, D-AP5, synaptic plasticity
- MeSH terms
- Animals, Aspartic Acid, Evoked Potentials, Somatosensory, Hippocampus, Membrane Potentials, Reference Values, Synapses, Valine, 2-Amino-5-phosphonovalerate, Receptors, N-Methyl-D-Aspartate, N-Methylaspartate, Receptors, Neurotransmitter, In Vitro Techniques
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