Cited by 88Neuroscience and Neuropharmacology ResearchMemory and Neural MechanismsStress Responses and Cortisol

Acute stress impairs (or induces) synaptic long‐term potentiation (LTP) but does not affect paired‐pulse facilitation in the stratum radiatum of rat hippocampus

Shors, Tracey J., Thompson, Richard F.·1992·Synapse

Abstract

Rats were exposed to restraint coupled with 60, 1‐sec, 1‐mA, 60‐Hz tail shocks. One hippocampus was immediately dissected for in vitro measurement of pairedpulse facilitation and LTP of the excitatory postsynaptic potential (EPSP) recording from the stratum radiatum of field CA1. There was no change in paired‐pulse facilitation, suggesting that acute exposure to the stressor does not result in a decrease in presynaptic neurotransmitter release. There was, however, a significant decrease in the percent LTP produced by theta burst stimulation relative to naïve controls. These results are consistent with the hypothesis that the stress‐induced impairment of LTP is a result of changes in the postsynaptic glutamate receptors, specifically the AMPA type. © Wiley‐Liss, Inc.

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Crossref · 10.1002/syn.890110311

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Authors
Shors, T. J., & Thompson, R. F.
Affiliations
  • Princeton University (US)
  • University of Southern California (US)
Venue
Synapse
Publisher
Wiley
Published
1992-07
Volume
11
Issue
3
Pages
262-265
ISSN
  • 0887-4476 (ISSN-L)
  • 1098-2396
OpenAlex
W2048684354
Cited by
88
References
20
Citations by year
2024: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 5
FWCI
1.88
Type
journal article
Language
en
Open access
closed
Locations
  • Synapse (publishedVersion)
  • PubMed (publishedVersion)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
  • Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
  • Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
Keywords
acute stress, long-term potentiation, paired-pulse facilitation, hippocampus, stratum radiatum, CA1, theta burst stimulation, excitatory postsynaptic potentials, presynaptic neurotransmitter release, AMPA receptors, postsynaptic glutamate receptors, restraint stress, tail shock
MeSH terms
Animals, Electric Stimulation, Electroencephalography, Evoked Potentials, Hippocampus, Male, Neuronal Plasticity, Stress, Psychological, Synapses, Receptors, Neurotransmitter, Receptors, AMPA, Rats

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