Acute stress impairs (or induces) synaptic long‐term potentiation (LTP) but does not affect paired‐pulse facilitation in the stratum radiatum of rat hippocampus
Abstract
Rats were exposed to restraint coupled with 60, 1‐sec, 1‐mA, 60‐Hz tail shocks. One hippocampus was immediately dissected for in vitro measurement of pairedpulse facilitation and LTP of the excitatory postsynaptic potential (EPSP) recording from the stratum radiatum of field CA1. There was no change in paired‐pulse facilitation, suggesting that acute exposure to the stressor does not result in a decrease in presynaptic neurotransmitter release. There was, however, a significant decrease in the percent LTP produced by theta burst stimulation relative to naïve controls. These results are consistent with the hypothesis that the stress‐induced impairment of LTP is a result of changes in the postsynaptic glutamate receptors, specifically the AMPA type. © Wiley‐Liss, Inc.
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Acute stress or corticosterone administration blocks hippocampal LTP.
“Our findings are consistent with recent work from other laboratories indicating that acute stress or corticosterone administration blocks hippocampal LTP (Shors et al. [141]; Shors and Thompson [142]; Pavlides et al. [143]; Pavlides et al. [144]; Pavlides et al. [145]; Garcia et al. [146]; Pavlides and McEwen [147]; Akirav and Richter-Levin [148]; Zhou et al. [149]; Wang et al. [150]; Garcia [15];”
From The Temporal Dynamics Model of Emotional Memory Processing: A Synthesis on the Neurobiological Basis of Stress-Induced Amnesia, Flashbulb and Traumatic Memories, and the Yerkes-Dodson Law (2007) · cites this paper as Shors and Thompson [142]
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- Self-citation
- Authors
- Shors, T. J., & Thompson, R. F.
- Affiliations
- Princeton University (US)
- University of Southern California (US)
- ORCID
- Shors, Tracey J.
- Venue
- Synapse
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- Wiley
- Published
- 1992-07
- Volume
- 11
- Issue
- 3
- Pages
- 262-265
- ISSN
- 0887-4476 (ISSN-L)
- 1098-2396
- OpenAlex
- W2048684354
- Cited by
- 88
- References
- 20
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- 2024: 1 · 2021: 1 · 2020: 1 · 2019: 2 · 2018: 2 · 2017: 1 · 2015: 1 · 2014: 3 · 2013: 3 · 2012: 5
- FWCI
- 1.88
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- journal article
- Language
- en
- Open access
- closed
- Locations
- Synapse (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Life Sciences › Neuroscience › Cognitive Neuroscience › Memory and Neural Mechanisms
- Life Sciences › Neuroscience › Behavioral Neuroscience › Stress Responses and Cortisol
- Keywords
- acute stress, long-term potentiation, paired-pulse facilitation, hippocampus, stratum radiatum, CA1, theta burst stimulation, excitatory postsynaptic potentials, presynaptic neurotransmitter release, AMPA receptors, postsynaptic glutamate receptors, restraint stress, tail shock
- MeSH terms
- Animals, Electric Stimulation, Electroencephalography, Evoked Potentials, Hippocampus, Male, Neuronal Plasticity, Stress, Psychological, Synapses, Receptors, Neurotransmitter, Receptors, AMPA, Rats
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Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
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