The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
A gene activated by growth factors is related to the oncogene v-jun.
Open accessAbstract
We have recently identified by cDNA cloning a set of genes that are rapidly activated in cultured mouse cells by protein growth factors. Here we report that the nucleotide sequence of a cDNA (clone 465) derived from one of these immediate early genes (hereafter called jun-B) encodes a protein homologous to that encoded by the avian sarcoma virus 17 oncogene v-jun. Homology between the jun-B and v-jun proteins is in two regions: one near the N terminus and the other at the C terminus. The latter sequence was shown by Vogt et al. [Vogt, P. K., Bos, T. J. & Doolittle, R. F. (1987) Proc. Natl. Acad. Sci. USA 84, 3316-3319] to have regions of sequence similarity to the DNA-binding domain of the yeast transcriptional regulatory protein GCN4 and to the oncogenic protein fos. Southern blots of human, mouse, and chicken DNA demonstrate that jun-B and c-jun are different genes and that there may be other vertebrate genes related to jun-B and c-jun. These findings suggest that there is a jun family of genes encoding related transcriptional regulatory proteins. The jun-B protein, and perhaps other members of the jun family, may play a role in regulating the genomic response to growth factors.
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Cites
Bohmann, D., Bos, T. J., Admon, A., Nishimura, T., Vogt, P. K., & Tjian, R. (1987) · Science · doi:10.1126/science.2825349 · Cited by 1,321
Identification of a set of genes expressed during the G0/G1 transition of cultured mouse cells.
Lau, L. F., & Nathans, D. (1985) · The EMBO Journal · doi:10.1002/j.1460-2075.1985.tb04057.x · Cited by 567
Self-citation
Cited by
Morgan, J. I., & Curran, T. (1991) · Annual Review of Neuroscience · doi:10.1146/annurev.ne.14.030191.002225 · Cited by 2,711
Karlin, S., & Altschul, S. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.6.2264 · Cited by 1,535
The jun proto-oncogene is positively autoregulated by its product, Jun/AP-1
Angel, P., Hattori, K., Smeal, T., & Karin, M. (1988) · Cell · doi:10.1016/0092-8674(88)90143-2 · Cited by 1,239
Contingent Genetic Regulatory Events in T Lymphocyte Activation
Crabtree, G. R. (1989) · Science · doi:10.1126/science.2783497 · Cited by 1,072
Absence Epilepsy in Tottering Mutant Mice Is Associated with Calcium Channel Defects
Fletcher, C. F., Lutz, C. M., O'Sullivan, T. N., Shaughnessy, J. D., Hawkes, R., Frankel, W. N., Copeland, N. G., & Jenkins, N. A. (1996) · Cell · doi:10.1016/s0092-8674(00)81381-1 · Cited by 772
Metadata
- Authors
- Ryder, K., Lau, L. F., & Nathans, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-03
- Volume
- 85
- Issue
- 5
- Pages
- 1487-1491
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2042917826
- Cited by
- 735
- References
- 2
- FWCI
- 36.47
- Type
- journal article
- Language
- en
- Open access
- green
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