The DOI matches its Crossref record; 34 of the 34 references it cites were found in a registry or an index.
Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes.
Open accessAbstract
In vitro DNA amplification followed by oligonucleotide dot blot analysis were used to study RAS gene mutations in acute myeloid leukemia (AML). Fifty-two presentation AML DNAs were screened for mutations in codons 12, 13, and 61 of NRAS and in codons 12 and 61 of KRAS and HRAS. Fourteen (27%) contained mutations--all in NRAS and predominantly in codon 12. The most common amino acid substitution identified was of glycine by aspartic acid at codon 12 (7/18), with a G----A transition being the most common base change (11/18). No particular correlation was observed between disease subtype and the incidence or type of NRAS mutation. In DNA samples from four patients, 2 NRAS mutations were found to coexist. NIH 3T3 focus-formation assays revealed that in each case the mutations were present in different NRAS alleles. We also report the absence of a mutated RAS gene in relapse DNAs of four patients in which a RAS oncogene had been detected at presentation. These observations suggest that RAS mutations arise as part of the evolution of neoplastic transformation.
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Self-citationMechanism of activation of a human oncogene
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Cited by
Mitochondrial DNA mutation associated with Leber’s hereditary optic neuropathy
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Positional cloning of zebrafish ferroportin1 identifies a conserved vertebrate iron exporter
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A point mutation of the rhodopsin gene in one form of retinitis pigmentosa
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A three-base-pair deletion in the peripherin–RDS gene in one form of retinitis pigmentosa
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Metadata
- Authors
- Farr, C. J., Saiki, R. K., Erlich, H. A., McCormick, F., & Marshall, C. J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-03
- Volume
- 85
- Issue
- 5
- Pages
- 1629-1633
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035049668
- Cited by
- 356
- References
- 34
- FWCI
- 31.74
- Type
- journal article
- Language
- en
- Open access
- green
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- Farr, C. J., Saiki, R. K., Erlich, H. A., McCormick, F., & Marshall, C. J. (1988). Analysis of RAS gene mutations in acute myeloid leukemia by polymerase chain reaction and oligonucleotide probes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.5.1629
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