Student or educator? Sign up with your school email and get 6 months of Pro free.
Cited by 1,158

The DOI matches its Crossref record; 95 of the 95 references it cites were found in a registry or an index.

The Polymerase Chain Reaction: A New Method of Using Molecular Genetics for Medical Diagnosis

Desforges, Jane F., Eisenstein, Barry I.·1990·New England Journal of Medicine

Abstract

THE development of molecular genetics, both as a self-contained field and as a body of techniques broadly useful in biologic investigation, has had a profound influence on medical research. The beneficiaries include every discipline in basic science and, at least indirectly, most clinical and applied medical disciplines. Certain technical milestones can be identified over the past several decades that have been particularly important in the progress of the field. One is the discovery of restriction endonucleases, which together with the development of DNA ligation and transformation procedures, led to the ability to clone and thus propagate genes of any organism . . .

Overview

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Integrity signals

Registry

Crossref · 10.1056/nejm199001183220307

Cites

95 of 95 references verified0 citation errors · 0 not checkable

Statistics

Verification

Claims the paper makes

The claims and statistics of this paper haven’t been checked yet.

Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.

A few free checks a day · papers already verified open instantly · results are public

Self-check

Percentages, sums and reported differences re-computed from the paper’s own numbers.

The self-check needs the paper’s full text.

Citations

Cites

Show all 95 references

Cited by

See all 1,158

Metadata

Authors
Desforges, J. F., & Eisenstein, B. I.
Venue
New England Journal of Medicine
Published
1990-01-18
Volume
322
Issue
3
Pages
178-183
ISSN
  • 0028-4793 (ISSN-L)
  • 1533-4406
OpenAlex
W1974590216
Cited by
1,158
References
95
FWCI
27.15
Type
journal article
Language
en
Open access
closed

About these checks

Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.

Statistics and arithmetic are recomputed, not judged.

Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.

What counts as a claim ›How we measure confidence ›How we check this ›

Are you an author, or do you see a problem with this page? Request a review

How to cite

Cite CoChat for the checks on this page, and the paper for its own findings.

This page
CoChat. (2026). Citation check: The Polymerase Chain Reaction: A New Method of Using Molecular Genetics for Medical Diagnosis. https://app.cochat.ai/papers/10.1056/nejm199001183220307
The paper
Desforges, J. F., & Eisenstein, B. I. (1990). The Polymerase Chain Reaction: A New Method of Using Molecular Genetics for Medical Diagnosis. New England Journal of Medicine. https://doi.org/10.1056/nejm199001183220307

Data sources

Bibliographic data: Semantic Scholar, OpenAlex, Crossref.

Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.