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Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H.
Open accessAbstract
Isolated complement components were used to study the regulation of the alternative complement pathway C3 convertase (EC 3.4.21.47), also called C3b,Bb, on M protein-carrying (M+) and M protein-lacking (M-) streptococci. Neither M- nor M+ streptococci directly affected the formation or dissociation of the surface-bound C3b,Bb or the inactivation of surface-bound C3b by factor I. However, the activity of the serum control protein of the alternative complement pathway, factor H, in controlling streptococcus-bound C3b and C3b,Bb was 6-8 times stronger on M+ organisms than on M- organisms. Furthermore, M+ streptococci of different serotypes and purified streptococcal M6 protein were shown to selectively bind factor H, the dissociation constants ranging from 4.5 X 10(-6) M to 6 X 10(-7) M. We conclude that the antiphagocytic activity of streptococcal M protein may be due to complement inhibition mediated by the binding of factor H. Binding of a regulatory protein appears to be a previously unrecognized route by which a pathogen is able to evade alternative pathway activation.
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Cites
Kazatchkine, M. D., Fearon, D. T., & Kf, A. (1979) · PubMed · Cited by 350
Cited by
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Navarre, W. W., & Schneewind, O. (1999) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.63.1.174-229.1999 · Cited by 1,391
Disease Manifestations and Pathogenic Mechanisms of Group A Streptococcus
Walker, M. J., Barnett, T. C., McArthur, J. D., Cole, J. N., Gillen, C. M., Henningham, A., Sriprakash, K. S., Sanderson-Smith, M. L., & Nizet, V. (2014) · Clinical Microbiology Reviews · doi:10.1128/cmr.00101-13 · Cited by 908
Gaillard, J.-L., Berche, P., Frehel, C., Gouln, E., & Cossart, P. (1991) · Cell · doi:10.1016/0092-8674(91)90009-n · Cited by 835
Viral Subversion of the Immune System
Tortorella, D., Gewurz, B. E., Furman, M. H., Schust, D. J., & Ploegh, H. L. (2000) · Annual Review of Immunology · doi:10.1146/annurev.immunol.18.1.861 · Cited by 835
Metadata
- Authors
- Horstmann, R. D., Sievertsen, H. J., Knobloch, J., & Fischetti, V. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-03
- Volume
- 85
- Issue
- 5
- Pages
- 1657-1661
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028247608
- Cited by
- 451
- References
- 1
- FWCI
- 3.35
- Type
- journal article
- Language
- en
- Open access
- green
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- Horstmann, R. D., Sievertsen, H. J., Knobloch, J., & Fischetti, V. A. (1988). Antiphagocytic activity of streptococcal M protein: selective binding of complement control protein factor H. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.5.1657
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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