Complement and its role in innate and adaptive immune responses

Dunkelberger, Jason R; Song, Wen-Chao

doi:10.1038/cr.2009.139

Cited by 1,932Complement system in diseasesBiomarkers in Disease MechanismsImmune Response and Inflammation

Complement and its role in innate and adaptive immune responses

Dunkelberger, Jason R, Song, Wen-Chao·2010·Cell Research

DOI 10.1038/cr.2009.139

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Abstract

The complement system plays a crucial role in the innate defense against common pathogens. Activation of complement leads to robust and efficient proteolytic cascades, which terminate in opsonization and lysis of the pathogen as well as in the generation of the classical inflammatory response through the production of potent proinflammatory molecules. More recently, however, the role of complement in the immune response has been expanded due to observations that link complement activation to adaptive immune responses. It is now appreciated that complement is a functional bridge between innate and adaptive immune responses that allows an integrated host defense to pathogenic challenges. As such, a study of its functions allows insight into the molecular underpinnings of host-pathogen interactions as well as the organization and orchestration of the host immune response. This review attempts to summarize the roles that complement plays in both innate and adaptive immune responses and the consequences of these interactions on host defense.

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From Age, sex and Alzheimer’s disease: a longitudinal study of 3xTg-AD mice reveals sex-specific disease trajectories and inflammatory responses mirrored in postmortem brains from Alzheimer’s patients (2024) · cites this paper as [51]
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Evaluation of C3A receptor expression on human leukocytes by the use of novel monoclonal antibodies
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Complement: a key system for immune surveillance and homeostasis
Ricklin, D., Hajishengallis, G., Yang, K., & Lambris, J. D. (2010) · Nature Immunology · doi:10.1038/ni.1923 · Cited by 3,654 · see citing works
Monoclonal antibodies: versatile platforms for cancer immunotherapy
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Complement System Part II: Role in Immunity
Merle, N. S., Noé, R., Halbwachs‐Mecarelli, L., Frémeaux‐Bacchi, V., & Roumenina, L. T. (2015) · Frontiers in Immunology · doi:10.3389/fimmu.2015.00257 · Cited by 1,054 · see citing works
Understanding age-related macular degeneration (AMD): Relationships between the photoreceptor/retinal pigment epithelium/Bruch’s membrane/choriocapillaris complex
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The complement system
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The inflammatory response to extracorporeal membrane oxygenation (ECMO): a review of the pathophysiology
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Complement Is Activated by IgG Hexamers Assembled at the Cell Surface
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Blood-Contacting Biomaterials: In Vitro Evaluation of the Hemocompatibility
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Biodistribution and delivery efficiency of unmodified tumor-derived exosomes
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Inflammation and its role in age-related macular degeneration
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Toll-like receptors in immunity and inflammatory diseases: Past, present, and future
Kumar, V. (2018) · International Immunopharmacology · doi:10.1016/j.intimp.2018.03.002 · Cited by 649 · see citing works
The role of the complement system in cancer
Afshar‐Kharghan, V. (2017) · Journal of Clinical Investigation · doi:10.1172/jci90962 · Cited by 558 · see citing works
Interactions between coagulation and complement—their role in inflammation
Οικονομοπούλου, Κ., Ricklin, D., Ward, P. A., & Lambris, J. D. (2011) · Seminars in Immunopathology · doi:10.1007/s00281-011-0280-x · Cited by 489 · see citing works
Immune system and immune responses in fish and their role in comparative immunity study: A model for higher organisms
Rauta, P. R., Nayak, B., & Das, S. (2012) · Immunology Letters · doi:10.1016/j.imlet.2012.08.003 · Cited by 485 · see citing works
Towards frailty biomarkers: Candidates from genes and pathways regulated in aging and age-related diseases
Cardoso, A. L., Fernandes, A. M. A., Aguilar‐Pimentel, J. A., de Angelis, M. H., Guedes, J. R., Brito, M. A., Ortolano, S., Pani, G., Athanasopoulou, S., Gonos, E. S., et al. (2018) · Ageing Research Reviews · doi:10.1016/j.arr.2018.07.004 · Cited by 471 · see citing works
Mung Bean (Vigna radiata L.): Bioactive Polyphenols, Polysaccharides, Peptides, and Health Benefits
Hou, D., Yousaf, L., Xue, Y., Hu, J., Wu, J., Hu, X., Feng, N., & Shen, Q. (2019) · Nutrients · doi:10.3390/nu11061238 · Cited by 454 · see citing works
Innate immunity in vertebrates: an overview
Riera‐Romo, M., Pérez‐Martínez, D., & Ferrer, C. C. (2016) · Immunology · doi:10.1111/imm.12597 · Cited by 437 · see citing works
Highly pathogenic coronavirus N protein aggravates inflammation by MASP-2-mediated lectin complement pathway overactivation
Gao, T., Hu, M., Zhang, X., Li, H., Zhu, L., Liu, H., Dong, Q., Zhang, Z., Wang, Z., Hu, Y., et al. (2022) · Signal Transduction and Targeted Therapy · doi:10.1101/2020.03.29.20041962 · Cited by 435 · see citing works
Neuromodulation by the immune system: a focus on cytokines
Salvador, A. F., de Lima, K. A., & Kipnis, J. (2021) · Nature Reviews Immunology · doi:10.1038/s41577-021-00508-z · Cited by 389 · see citing works
Immunogenicity and toxicity of AAV gene therapy
Ertl, H. C. J. (2022) · Frontiers in Immunology · doi:10.3389/fimmu.2022.975803 · Cited by 402 · see citing works
Pathogenesis of pneumonia and acute lung injury
Long, M. E., Mallampalli, R. K., & Horowitz, J. C. (2022) · Clinical Science · doi:10.1042/cs20210879 · Cited by 410 · see citing works
Role of the Immune System in Hypertension
Rodríguez‐Iturbe, B., Pons, H., & Johnson, R. J. (2017) · Physiological Reviews · doi:10.1152/physrev.00031.2016 · Cited by 393 · see citing works
Polymeric Delivery of Therapeutic Nucleic Acids
Kumar, R., Chalarca, C. F. S., Bockman, M. R., Bruggen, C. V., Grimme, C. J., Dalal, R. J., Hanson, M. G., Hexum, J. K., & Reineke, T. M. (2021) · Chemical Reviews · doi:10.1021/acs.chemrev.0c00997 · Cited by 370 · see citing works
The role of nanotechnology in the treatment of viral infections
Singh, L., Kruger, H. G., Maguire, G. E. M., Govender, T., & Parboosing, R. (2017) · Therapeutic Advances in Infectious Disease · doi:10.1177/2049936117713593 · Cited by 364 · see citing works
Main Components of Fish Immunity: An Overview of the Fish Immune System
Mokhtar, D. M., Zaccone, G., Alesci, A., Kuciel, M., Hussein, M. T., & Sayed, R. K. A. (2023) · Fishes · doi:10.3390/fishes8020093 · Cited by 358 · see citing works
Epidemiology and Immune Pathogenesis of Viral Sepsis
Lin, G.-L., McGinley, J. P., Drysdale, S. B., & Pollard, A. J. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.02147 · Cited by 351 · see citing works
Ginseng, the 'Immunity Boost': The Effects of Panax ginseng on Immune System
Kang, S., & Min, H. (2012) · Journal of Ginseng Research · doi:10.5142/jgr.2012.36.4.354 · Cited by 353 · see citing works
Adverse Effects of Vaccines: Evidence and Causality
Stratton, K. R., Ford, A. Q., Rusch, E., & Clayton, E. W. (2013) · Cited by 346 · see citing works
The response of fish to immunostimulant diets
Vallejos‐Vidal, E., Reyes‐López, F. E., Teles, M., & MacKenzie, S. A. (2016) · Fish & Shellfish Immunology · doi:10.1016/j.fsi.2016.06.028 · Cited by 339 · see citing works
Beyond phytohaemagglutinin: assessing vertebrate immune function across ecological contexts
Demas, G. E., Zysling, D. A., Beechler, B. R., Muehlenbein, M. P., & French, S. S. (2011) · Journal of Animal Ecology · doi:10.1111/j.1365-2656.2011.01813.x · Cited by 334 · see citing works
Modulation of Immune Responses by Particle Size and Shape
Baranov, M. V., Kumar, M., Sacanna, S., Thutupalli, S., & van den Bogaart, G. (2021) · Frontiers in Immunology · doi:10.3389/fimmu.2020.607945 · Cited by 324 · see citing works
Harnessing the immune system to improve cancer therapy
Papaioannou, N. E., Beniata, O. V., Vitsos, P., Tsitsilonis, O., & Samara, P. (2016) · Annals of Translational Medicine · doi:10.21037/atm.2016.04.01 · Cited by 311 · see citing works
A Comparison of the Innate and Adaptive Immune Systems in Cartilaginous Fish, Ray-Finned Fish, and Lobe-Finned Fish
Smith, N. C. P., Rise, M. L., & Christian, S. L. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.02292 · Cited by 300 · see citing works
Genetic and Functional Diversity of Pseudomonas aeruginosa Lipopolysaccharide
Lam, J. S., Taylor, V. L., Islam, S. T., Hao, Y., & Kocíncová, D. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00118 · Cited by 299 · see citing works
Structures of C3b in Complex with Factors B and D Give Insight into Complement Convertase Formation
Forneris, F., Ricklin, D., Wu, J., Τζέκου, Α., Wallace, R. S., Lambris, J. D., & Gros, P. (2010) · Science · doi:10.1126/science.1195821 · Cited by 289 · see citing works
Complement and the Regulation of T Cell Responses
West, E. E., Kolev, M. V., & Kemper, C. (2018) · Annual Review of Immunology · doi:10.1146/annurev-immunol-042617-053245 · Cited by 271 · see citing works
The Immune System in Cancer Pathogenesis: Potential Therapeutic Approaches
Pandya, P. H., Murray, M. E., Pollok, K. E., & Renbarger, J. L. (2016) · Journal of Immunology Research · doi:10.1155/2016/4273943 · Cited by 260 · see citing works
B cells in the tumor microenvironment: Multi-faceted organizers, regulators, and effectors of anti-tumor immunity
Laumont, C. M., & Nelson, B. H. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.017 · Cited by 255 · see citing works
Obligatory Role for B Cells in the Development of Angiotensin II–Dependent Hypertension
Chan, C. T., Sobey, C. G., Lieu, M., Ferens, D. M., Kett, M. M., Diep, H., Kim, H. A., Krishnan, S. M., Lewis, C., Salimova, E., et al. (2015) · Hypertension · doi:10.1161/hypertensionaha.115.05779 · Cited by 242 · see citing works
Revisiting the Page & Schroeder model: the good, the bad and the unknowns in the periodontal host response 40 years later
Hajishengallis, G., & Korostoff, J. M. (2017) · Periodontology 2000 · doi:10.1111/prd.12181 · Cited by 245 · see citing works
Structure–immunomodulatory activity relationships of dietary polysaccharides
Chen, R., Xu, J., Wu, W., Wen, Y., Lu, S., El-Seedi, H. R., & Zhao, C. (2022) · Current Research in Food Science · doi:10.1016/j.crfs.2022.08.016 · Cited by 243 · see citing works
Complement deficiency states and associated infections
Skattum, L., van Deuren, M., van der Poll, T., & Truedsson, L. (2011) · Molecular Immunology · doi:10.1016/j.molimm.2011.05.001 · Cited by 238 · see citing works
Neutrophils and Immunity: From Bactericidal Action to Being Conquered
Teng, T., Ji, A.-L., Ji, X., & Li, Y. (2017) · Journal of Immunology Research · doi:10.1155/2017/9671604 · Cited by 237 · see citing works
Oligodendrocyte death and myelin loss in the cuprizone model: an updated overview of the intrinsic and extrinsic causes of cuprizone demyelination
Zirngibl, M., Assinck, P., Sizov, A., Caprariello, A. V., & Plemel, J. R. (2022) · Molecular Neurodegeneration · doi:10.1186/s13024-022-00538-8 · Cited by 233 · see citing works
Rediscovery of mononuclear phagocyte system blockade for nanoparticle drug delivery
Zelepukin, I. V., Shevchenko, K. G., & Deyev, S. M. (2024) · Nature Communications · doi:10.1038/s41467-024-48838-5 · Cited by 232 · see citing works
Age related macular degeneration and drusen: Neuroinflammation in the retina
Buschini, E., Piras, A., Nuzzi, R., & Vercelli, A. (2011) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2011.05.011 · Cited by 230 · see citing works
Immune System Dysfunction in the Elderly
Eduardo Fuentes, Q., FUENTES, M., Alarcón, M. A., & Palomo, I. F. (2017) · Anais da Academia Brasileira de Ciências · doi:10.1590/0001-3765201720160487 · Cited by 234 · see citing works
Strategies to reduce the risks of mRNA drug and vaccine toxicity
Bitounis, D., Jacquinet, E., Rogers, M. A., & Amiji, M. M. (2024) · Nature Reviews Drug Discovery · doi:10.1038/s41573-023-00859-3 · Cited by 237 · see citing works
Alzheimer risk associated with a copy number variation in the complement receptor 1 increasing C3b/C4b binding sites
Brouwers, N., Van Cauwenberghe, C., Engelborghs, S., Lambert, J.-C., Bettens, K., Le Bastard, N., Pasquier, F., Montoya, A. G., Peeters, K., Mattheijssens, M., et al. (2012) · Molecular Psychiatry · doi:10.1038/mp.2011.24 · Cited by 227 · see citing works
Immune determinants of the pre-metastatic niche
Pătraș, L., Shaashua, L., Matei, I. R., & Lyden, D. C. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.02.018 · Cited by 223 · see citing works
Lipid nanoparticles (LNPs) for in vivo RNA delivery and their breakthrough technology for future applications
Jeong, M., Lee, Y., Park, J., Jung, H., & Lee, H. (2023) · Advanced Drug Delivery Reviews · doi:10.1016/j.addr.2023.114990 · Cited by 227 · see citing works
Osteoclast-Derived Complement Component 3a Stimulates Osteoblast Differentiation
Matsuoka, K., Park, K.-A., Ito, M., Ikeda, K., & Takeshita, S. (2014) · Journal of Bone and Mineral Research · doi:10.1002/jbmr.2187 · Cited by 216 · see citing works
Hypertension
Madhur, M. S., Elijovich, F., Alexander, M. R., Pitzer, A. L., Ishimwe, J., Beusecum, J. P. V., Patrick, D. M., Smart, C. D., Kleyman, T. R., Kingery, J. R., et al. (2021) · Circulation Research · doi:10.1161/circresaha.121.318052 · Cited by 215 · see citing works
Neutrophil-activating therapy for the treatment of cancer
Linde, I. L., Prestwood, T. R., Qiu, J., Pilarowski, G. O. W., Linde, M. H., Zhang, X., Shen, L., Reticker-Flynn, N. E., Chiu, D. K., Sheu, L. Y., et al. (2023) · Cancer Cell · doi:10.1016/j.ccell.2023.01.002 · Cited by 204 · see citing works
Self-citation
The draft genome of the large yellow croaker reveals well-developed innate immunity
Wu, C., Zhang, D., Kan, M., Lv, Z., Zhu, A., Su, Y., Zhou, D., Zhang, J., Zhang, Z., Xu, M., et al. (2014) · Nature Communications · doi:10.1038/ncomms6227 · Cited by 205 · see citing works
Mediators of Inflammation
Galvão, I., Sugimoto, M. A., Vago, J. P., Machado, M. G., & Sousa, L. P. (2018) · Springer eBooks · doi:10.1007/978-3-319-77658-3_1 · Cited by 202 · see citing works
Positive Crossmatch Kidney Transplant Recipients Treated With Eculizumab: Outcomes Beyond 1 Year
Cornell, L. D., Schinstock, C. A., Gandhi, M. J., Kremers, W. K., & Stegall, M. D. (2015) · American Journal of Transplantation · doi:10.1111/ajt.13168 · Cited by 199 · see citing works
Interactions between Borrelia burgdorferi and ticks
Kurokawa, C., Lynn, G. E., Pedra, J. H. F., Pal, U., Narasimhan, S., & Fikrig, E. (2020) · Nature Reviews Microbiology · doi:10.1038/s41579-020-0400-5 · Cited by 199 · see citing works
Inflammation balance in skeletal muscle damage and repair
Tu, H., & Li, Y. (2023) · Frontiers in Immunology · doi:10.3389/fimmu.2023.1133355 · Cited by 212 · see citing works
Complement factor H in host defense and immune evasion
Parente, R., Clark, S. J., Inforzato, A., & Day, A. J. (2016) · Cellular and Molecular Life Sciences · doi:10.1007/s00018-016-2418-4 · Cited by 193 · see citing works
Mucosal immune response in biology, disease prevention and treatment
Zhou, X., Wu, Y., Zhu, Z., Lu, C., Zhang, C., Zeng, L., Xie, F., Zhang, L., & Zhou, F. (2025) · Signal Transduction and Targeted Therapy · doi:10.1038/s41392-024-02043-4 · Cited by 218 · see citing works
Pegvaliase for the treatment of phenylketonuria: Results of a long-term phase 3 clinical trial program (PRISM)
Thomas, J. A., Levy, H. L., Amato, S., Vockley, J. E., Zori, R. T., Dimmock, D., Harding, C. O., Bilder, D. A., Weng, H. H., Olbertz, J., et al. (2018) · Molecular Genetics and Metabolism · doi:10.1016/j.ymgme.2018.03.006 · Cited by 192 · see citing works
Targeting microglia for the treatment of Alzheimer’s Disease
Wes, P. D., Sayed, F. A., Bard, F., & Gan, L. (2016) · Glia · doi:10.1002/glia.22988 · Cited by 185 · see citing works
Adsorption of Surfactant Lipids by Single-Walled Carbon Nanotubes in Mouse Lung upon Pharyngeal Aspiration
Kapralov, A. A., Feng, W. H., Amoscato, A. A., Yanamala, N. V. K., Balasubramanian, K., Winnica, D., Kisin, E. R., Kotchey, G. P., Gou, P., Sparvero, L. J., et al. (2012) · ACS Nano · doi:10.1021/nn300626q · Cited by 177 · see citing works
Mechanisms of action of therapeutic antibodies for cancer
Redman, J. M., Hill, E., Aldeghaither, D. S., & Weiner, L. M. (2015) · Molecular Immunology · doi:10.1016/j.molimm.2015.04.002 · Cited by 171 · see citing works
Monoclonal antibodies for the treatment of cancer
Shuptrine, C. W., Surana, R., & Weiner, L. M. (2012) · Seminars in Cancer Biology · doi:10.1016/j.semcancer.2011.12.009 · Cited by 172 · see citing works
Deception and Manipulation: The Arms of Leishmania, a Successful Parasite
Cecílio, P., Pérez‐Cabezas, B., Santarém, N., Maciel, J., Rodrigues, V., & Cordeiro‐da‐Silva, A. (2014) · Frontiers in Immunology · doi:10.3389/fimmu.2014.00480 · Cited by 165 · see citing works
CAF-macrophage crosstalk in tumour microenvironments governs the response to immune checkpoint blockade in gastric cancer peritoneal metastases
Li, Y., Zheng, Y., Huang, J., Nie, R., Wu, Q., Zuo, Z., Yuan, S., Yu, K., Liang, C., Pan, Y., et al. (2024) · Gut · doi:10.1136/gutjnl-2024-333617 · Cited by 178 · see citing works
Innate Immunity in the Persistent Inflammation, Immunosuppression, and Catabolism Syndrome and Its Implications for Therapy
Horiguchi, H., Loftus, T. J., Hawkins, R. B., Raymond, S. L., Stortz, J. A., Hollen, M. K., Weiss, B. P., Miller, E. S., Bihorac, A., Larson, S. D., et al. (2018) · Frontiers in Immunology · doi:10.3389/fimmu.2018.00595 · Cited by 164 · see citing works
Studying Neutrophil Function in vitro: Cell Models and Environmental Factors
Blanter, M., Gouwy, M., & Struyf, S. (2021) · Journal of Inflammation Research · doi:10.2147/jir.s284941 · Cited by 152 · see citing works
Biochemical aspects of the inflammatory process: A narrative review
Soares, C. L. R., Wilairatana, P., Silva, L. R., Moreira, P. S., Barbosa, N. M. M. V., da Silva, P. R., Coutinho, H. D. M., de Menezes, I. R. A., & Felipe, C. F. B. (2023) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2023.115764 · Cited by 170 · see citing works
VEGF regulates local inhibitory complement proteins in the eye and kidney
Keir, L. S., Firth, R., Aponik, L., Feitelberg, D., Sakimoto, S., Aguilar, E., Welsh, G. I., Richards, A., Usui, Y., Satchell, S. C., et al. (2016) · Journal of Clinical Investigation · doi:10.1172/jci86418 · Cited by 154 · see citing works
Life-Threatening Infectious Complications in Sickle Cell Disease: A Concise Narrative Review
Ochocinski, D., Dalal, M., Black, L. V., Carr, S. B., Lew, J., Sullivan, K., & Kissoon, N. “. (2020) · Frontiers in Pediatrics · doi:10.3389/fped.2020.00038 · Cited by 162 · see citing works
Late-Onset Alzheimer’s Disease Genes and the Potentially Implicated Pathways
Rosenthal, S. L., & Kamboh, M. I. (2014) · Current Genetic Medicine Reports · doi:10.1007/s40142-014-0034-x · Cited by 153 · see citing works
Natural IgM in Immune Equilibrium and Harnessing Their Therapeutic Potential
Kaveri, S. V., Silverman, G. J., & Bayry, J. (2012) · The Journal of Immunology · doi:10.4049/jimmunol.1102107 · Cited by 150 · see citing works
Trial Watch: Monoclonal antibodies in cancer therapy
Galluzzi, L., Vacchelli, E., Fridman, W. H., Galon, J., Sautès‐Fridman, C., Tartour, É., Zucman‐Rossi, J., Zitvogel, L., & Kroemer, G. (2012) · OncoImmunology · doi:10.4161/onci.1.1.17938 · Cited by 150 · see citing works
IgG Fc domains that bind C1q but not effector Fcγ receptors delineate the importance of complement-mediated effector functions
Lee, C., Romain, G., Yan, W., Watanabe, M., Charab, W., Todorova, B., Lee, J., Triplett, K. C., Donkor, M. K., Lungu, O. I., et al. (2017) · Nature Immunology · doi:10.1038/ni.3770 · Cited by 146 · see citing works
Immunity in Molluscs: Recognition and Effector Mechanisms, with a Focus on Bivalvia
Gerdol, M., Marta Gómez-chiarri, G., Castillo, M. G., Figueras, A. J., Fiorito, G., Moreira, R., Novoa, B., Pallavicini, A., Ponte, G., Roumbedakis, K., et al. (2018) · Springer eBooks · doi:10.1007/978-3-319-76768-0_11 · Cited by 146 · see citing works
Hyperactivation of P2X7 receptors as a culprit of COVID-19 neuropathology
Ribeiro, D. E., Oliveira-Giacomelli, Á., Glaser, T., Arnaud-Sampaio, V. F., Andrejew, R., Dieckmann, L., Baranova, J., Lameu, C., Ratajczak, M. Z., & Ulrich, H. (2021) · Molecular Psychiatry · doi:10.1038/s41380-020-00965-3 · Cited by 145 · see citing works
A critical review on serine protease: Key immune manipulator and pathology mediator
Patel, S. V. (2017) · Allergologia et Immunopathologia · doi:10.1016/j.aller.2016.10.011 · Cited by 146 · see citing works
The Functional Power of the Human Milk Proteome
Zhu, J., & Dingess, K. A. (2019) · Nutrients · doi:10.3390/nu11081834 · Cited by 145 · see citing works
Emerging Biosensing Technologies for the Diagnostics of Viral Infectious Diseases
Kabay, G., DeCastro, J., Altay, A., Smith, K., Lu, H., Capossela, A. M., Moarefian, M., Aran, K., & Dincer, C. (2022) · Advanced Materials · doi:10.1002/adma.202201085 · Cited by 146 · see citing works
Estradiol-Treated Female Mice as Surrogate Hosts for Neisseria gonorrhoeae Genital Tract Infections
Jerse, A. E., Wu, H., Packiam, M., Vonck, R. A., Begum, A. A., & Garvin, L. E. (2011) · Frontiers in Microbiology · doi:10.3389/fmicb.2011.00107 · Cited by 141 · see citing works
Different Molecular Signatures in Magnetic Resonance Imaging-Staged Facioscapulohumeral Muscular Dystrophy Muscles
Tasca, G. A., Pescatori, M., Monforte, M., Massimiliano Mirabella, A., Iannaccone, E., Frusciante, R., Cubeddu, T., Laschena, F., Ottaviani, P., & Ricci, E. (2012) · PLoS ONE · doi:10.1371/journal.pone.0038779 · Cited by 141 · see citing works
Complement anaphylatoxins C3a and C5a: Emerging roles in cancer progression and treatment
Ajona, D., Ortiz‐Espinosa, S., & Pı́o, R. (2017) · Seminars in Cell and Developmental Biology · doi:10.1016/j.semcdb.2017.11.023 · Cited by 141 · see citing works
Age-related neurodegenerative disease associated pathways identified in retinal and vitreous proteome from human glaucoma eyes
Mirzaei, M., Gupta, V. B., Chick, J. M., Greco, T. M., Wu, Y., Chitranshi, N., Wall, R. V., Hone, E., Deng, L., Dheer, Y., et al. (2017) · Scientific Reports · doi:10.1038/s41598-017-12858-7 · Cited by 140 · see citing works
The Role of Reactive Species on Innate Immunity
Andrés, C., Pérez de la Lastra, J., Juan, C., Plou, F., & Pérez-Lebeña, E. (2022) · Vaccines · doi:10.3390/vaccines10101735 · Cited by 142 · see citing works
Candida albicans and Oral Carcinogenesis. A Brief Review
Cosola, M. D., Cazzolla, A. P., Charitos, I. A., Ballini, A., Inchingolo, F., & Santacroce, L. (2021) · Journal of Fungi · doi:10.3390/jof7060476 · Cited by 147 · see citing works
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Authors: Dunkelberger, J. R., & Song, W.-C.
Affiliations: University of Pennsylvania (US)
Corresponding author: Song, Wen-Chao
ORCID: Song, Wen-Chao
Venue: Cell Research
Publisher: Springer Science and Business Media LLC
Published: 2009-12-15
Volume: 20
Issue: 1
Pages: 34-50
ISSN: 1001-0602 (ISSN-L)
1748-7838
DOI: 10.1038/cr.2009.139
OpenAlex: W2005044790
Cited by: 1,932
References: 170
Citations by year: 2026: 163 · 2025: 207 · 2024: 239 · 2023: 192 · 2022: 149 · 2021: 186 · 2020: 103 · 2019: 85 · 2018: 103 · 2017: 98 · 2016: 95 · 2015: 67 · 2014: 65 · 2013: 49 · 2012: 68
FWCI: 3.37
Type: journal article
Language: en
Open access: closed
Licence: www.springer.com/tdm (tdm)
Locations: Cell Research (publishedVersion)
PubMed (publishedVersion)
Funders: American Heart Association
National Institutes of Health
Topics: Life Sciences › Immunology and Microbiology › Immunology › Complement system in diseases
Life Sciences › Immunology and Microbiology › Immunology › Biomarkers in Disease Mechanisms
Life Sciences › Immunology and Microbiology › Immunology › Immune Response and Inflammation
Keywords: complement system, innate immunity, adaptive immunity, complement activation, opsonization, proinflammatory molecules, host-pathogen interaction
MeSH terms: Animals, B-Lymphocytes, Complement System Proteins, Humans, Immunity, Innate, Inflammation, T-Lymphocytes, Inflammation Mediators, Host-Pathogen Interactions, Adaptive Immunity, Immunity, Humoral

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