The DOI matches its Crossref record; 42 of the 42 references it cites were found in a registry or an index.
Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer.
Open accessAbstract
We have identified in mouse hepatoma cells a third cis-acting dioxin-responsive element (DRE) within the 5' flanking region of the cytochrome P1-450 gene, which is transcriptionally activated by 2,3,7,8-tetrachlorodibenzo-p-dioxin (TCDD). The DRE can activate a heterologous promoter and functions in either orientation; therefore, it has the properties of a transcriptional enhancer. The DRE fails to activate transcription in receptor-defective cells; therefore, it requires TCDD-receptor complexes for its function. By using a gel retardation assay, we show that nuclear extracts contain a protein that binds to the DRE in TCDD-inducible, receptor-dependent, and DNA sequence-specific fashion. The protein-DNA interaction occurs within 10 min of exposure of the cell to TCDD and does not require ongoing protein synthesis. Our results imply that the TCDD-receptor complex interacts specifically with the DRE and demonstrate a relationship between protein-DNA interaction in vitro and function in vivo. Our findings also suggest that the affinity of the TCDD-receptor complex for the DRE may be relatively high in comparison to analogous protein-DNA interactions at other inducible enhancers.
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Unidirectional digestion with exonuclease III creates targeted breakpoints for DNA sequencing
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Self-citation
Metadata
- Authors
- Denison, M. S., Fisher, J. M., & Whitlock, J. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1988-04
- Volume
- 85
- Issue
- 8
- Pages
- 2528-2532
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1996954653
- Cited by
- 260
- References
- 42
- FWCI
- 22.29
- Type
- journal article
- Language
- en
- Open access
- green
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- Denison, M. S., Fisher, J. M., & Whitlock, J. P. (1988). Inducible, receptor-dependent protein-DNA interactions at a dioxin-responsive transcriptional enhancer. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.85.8.2528
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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