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Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes.
Open accessAbstract
An increasing body of evidence has suggested trophic effects of peripheral nerves. In this study, the growth stimulatory properties of the sensory neuropeptides vasoactive intestinal polypeptide (VIP), substance P (SP), calcitonin generelated peptide (CGRP), and somatostatin (SOM) on cultured human keratinocytes were investigated. It was shown that VIP, in the presence of lethally treated 3T3 fibroblast feeder cells and epidermal growth factor (EGF), stimulated proliferation of keratinocytes in a dose-dependent manner, whereas SP, CGRP, and SOM were ineffective. VIP stimulated adenylate cyclase activity in membranes obtained from cultured keratinocytes in a dose-dependent manner, indicating an involvement of cAMP as second messenger in this reaction. Furthermore, 125I-labeled VIP was shown to bind to cultured keratinocytes and this binding could be displaced by addition of unlabeled VIP, suggesting the presence of specific receptors. It is therefore possible that VIP, released from sensory nerve endings in the skin, may act as a local mitogenic factor for human keratinocytes by stimulating adenylate cyclase activity via specific VIP receptors.
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Citations
Cited by
Neuronal Control of Skin Function: The Skin as a Neuroimmunoendocrine Organ
Roosterman, D., Goerge, T., Schneider, S. W., Bunnett, N. W., & Steinhoff, M. (2006) · Physiological Reviews · doi:10.1152/physrev.00026.2005 · Cited by 665
Inverse, protean, and ligand‐selective agonism: matters of receptor conformation
KENAKIN, T. (2001) · The FASEB Journal · doi:10.1096/fj.00-0438rev · Cited by 408
Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems
Scholzen, T., Armstrong, C. A., Bunnett, N. W., Luger, T. A., Olerud, J. E., & Ansel, J. C. (1998) · Experimental Dermatology · doi:10.1111/j.1600-0625.1998.tb00307.x · Cited by 391
Garg, A., Chren, M.-M., Sands, L. P., Matsui, M. S., Marenus, K. D., Feingold, K. R., & Elias, P. M. (2001) · Archives of Dermatology · doi:10.1001/archderm.137.1.53 · Cited by 384
Modern Aspects of Cutaneous Neurogenic Inflammation
Steinhoff, M., Ständer, S., Seeliger, S., Ansel, J. C., Schmelz, M., & Luger, T. (2003) · Archives of Dermatology · doi:10.1001/archderm.139.11.1479 · Cited by 346
Metadata
- Authors
- Haegerstrand, A., Jonzon, B., Dalsgaard, C. J., & Nilsson, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-08
- Volume
- 86
- Issue
- 15
- Pages
- 5993-5996
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1969040012
- Cited by
- 169
- References
- 0
- FWCI
- 4.25
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes. https://app.cochat.ai/papers/10.1073/pnas.86.15.5993
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- Haegerstrand, A., Jonzon, B., Dalsgaard, C. J., & Nilsson, J. (1989). Vasoactive intestinal polypeptide stimulates cell proliferation and adenylate cyclase activity of cultured human keratinocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.15.5993
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
