The DOI matches its Crossref record; 131 of the 131 references it cites were found in a registry or an index.
Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems
Abstract
Abstract:The interaction between components of the nervous system and multiple target cells in the cutaneous immune system has been receiving increasing attention. It has been observed that certain skin diseases such as psoriasis and atopic dermatitis have a neurogenic component. Neuropeptides released by sensory nerves that innervate the skin and often contact epidermal and dermal cells can directly modulate functions of keratinocytes, Langerhans cells (LC), mast cells, dermal microvascular endothelial cells and infiltrating immune cells. Among these neuropeptides the tachykinins substance P (SP) and neurokinin A (NKA), calcitonin gene related peptide (CGRP), vasoactive intestinal peptide (VIP) and somato statin (SOM) have been reported to effectively modulate skin and immune cell functions such as cell proliferation, cytokine production or antigen presentation under physiological or pathophysiological conditions. Expression and regulation of their corresponding receptors that are expressed on a variety of skin cells as well as the presence of neuropeptidespecific peptidases such as neutral endopeptidase (NEP) or angiotensinconverting enzyme (ACE) determine the final biological response mediated by these peptides on the target cell or tissue. Likewise, skin cells like keratinocytes or fibroblasts are a source for neurotrophins such as nerve growth factor that are required not only for survival and regeneration of sensory neurons but also to control responsiveness of these neurons to external stimuli. Therefore, neuropeptides, neuropeptide receptors, neuropeptidedegrading enzymes and neurotrophins participate in a complex, interdependent network of mediators that modulate skin inflammation, wound healing and the skin immune system. This review will focus on recent studies demonstrating the role of tachykinins, CGRP, SOM and VIP and their receptors and neuropeptide‐degrading enzymes in mediating neurogenic inflammation in the skin.
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Cites
The capsaicin receptor: a heat-activated ion channel in the pain pathway
Caterina, M. J., Schumacher, M. A., Tominaga, M., Rosen, T. A., Levine, J. D., & Julius, D. (1997) · Nature · doi:10.1038/39807 · Cited by 9,107
Reichlin, S. (1983) · New England Journal of Medicine · doi:10.1056/nejm198312153092406 · Cited by 1,044
Human preprovasoactive intestinal polypeptide contains a novel PHI-27-like peptide, PHM-27
Itoh, N., Obata, K.-I., Yanaihara, N., & Okamoto, H. (1983) · Nature · doi:10.1038/304547a0 · Cited by 683
Stimulation of connective tissue cell growth by substance P and substance K
Nilsson, J., von Euler, A. M., & Dalsgaard, C.-J. (1985) · Nature · doi:10.1038/315061a0 · Cited by 679
Angiotensin-Converting Enzyme: Vascular Endothelial Localization
Caldwell, P. R. B., Seegal, B. C., Hsu, K. C., Das, M., & Soffer, R. L. (1976) · Science · doi:10.1126/science.175444 · Cited by 635
Receptors and antagonists for substance P and related peptides.
Regoli, D., Boudon, A., & Fauchére, J. L. (1994) · Pharmacological Reviews · doi:10.1016/s0031-6997(25)06810-3 · Cited by 631
Regulation of Langerhans cell function by nerves containing calcitonin gene-related peptide
Hosoi, J., Murphy, G. F., Egan, C. L., Lerner, E. A., Grabbe, S., Asahina, A., & Granstein, R. D. (1993) · Nature · doi:10.1038/363159a0 · Cited by 631
Amara, S. G., Arriza, J. L., Leff, S. E., Swanson, L. W., Evans, R. M., & Rosenfeld, M. G. (1985) · Science · doi:10.1126/science.2994212 · Cited by 610
Classification and nomenclature of somatostatin receptors
Hoyer, D., Bell, G. I., Berelowitz, M., Epelbaum, J., Feniuk, W., Humphrey, P. P. A., O'Carroll, A.-M., Patel, Y. C., Schonbrunn, A., Taylor, J. E., et al. (1995) · Trends in Pharmacological Sciences · doi:10.1016/s0165-6147(00)88988-9 · Cited by 570
The melanocortin receptors: agonists, antagonists, and the hormonal control of pigmentation.
Cone, R. D., Lu, D., Koppula, S. V., Våge, D. I., Klungland, H., Boston, B. A., Chen, W., Orth, D. N., Pouton, C. W., & Kesterson, R. A. (1996) · PubMed · Cited by 518
Cited by
Calcitonin Gene-Related Peptide: Physiology and Pathophysiology
Russell, F. A., King, R., Smillie, S.-J., Kodji, X., & Brain, S. D. (2014) · Physiological Reviews · doi:10.1152/physrev.00034.2013 · Cited by 1,258
Neuroendocrinology of the Skin1
Slominski, A., & Wortsman, J. (2000) · Endocrine Reviews · doi:10.1210/edrv.21.5.0410 · Cited by 727
The molecular biology of chronic wounds and delayed healing in diabetes
Blakytny, R., & Jude, E. (2006) · Diabetic Medicine · doi:10.1111/j.1464-5491.2006.01773.x · Cited by 632
New developments in our understanding of acne pathogenesis and treatment
Kurokawa, I., Danby, F. W., Ju, Q., Wang, X., Xiang, L. F., Xia, L., Chen, W., Nagy, I., Picardo, M., Suh, D. H., et al. (2009) · Experimental Dermatology · doi:10.1111/j.1600-0625.2009.00890.x · Cited by 584
Toyoda, M., Nakamura, M., Makino, T., Hino, T., Kagoura, M., & Morohashi, M. (2002) · British Journal of Dermatology · doi:10.1046/j.1365-2133.2002.04803.x · Cited by 339
Metadata
- Authors
- Scholzen, T., Armstrong, C. A., Bunnett, N. W., Luger, T. A., Olerud, J. E., & Ansel, J. C.
- Venue
- Experimental Dermatology
- Publisher
- Wiley
- Published
- 1998-06
- Volume
- 7
- Issue
- 2-3
- Pages
- 81-96
- ISSN
- 0906-6705 (ISSN-L)
- 1600-0625
- OpenAlex
- W2105464073
- Cited by
- 391
- References
- 131
- FWCI
- 7.18
- Type
- journal article
- Language
- en
- Open access
- closed
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- Scholzen, T., Armstrong, C. A., Bunnett, N. W., Luger, T. A., Olerud, J. E., & Ansel, J. C. (1998). Neuropeptides in the skin: interactions between the neuroendocrine and the skin immune systems. Experimental Dermatology. https://doi.org/10.1111/j.1600-0625.1998.tb00307.x
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