The DOI matches its Crossref record; 37 of the 37 references it cites were found in a registry or an index.
Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus.
Open accessAbstract
Rat astrocytes, immunologically competent glial cells of the central nervous system (CNS), released a variety of cytokines after activation. Lipopolysaccharide-stimulated astrocytes produced tumor necrosis factor (TNF) as demonstrated by Northern blot analysis using a mouse TNF probe and by functional assay. Biological activity of rat astrocyte-derived TNF was neutralized by rabbit antiserum against recombinant murine TNF. Stimulation of astrocytes by lipopolysaccharide also activated the interleukin 1 and interleukin 6 genes. We have also investigated whether a neurotropic paramyxovirus, Newcastle disease virus, triggers cytokine production by astrocytes. This virus induced astrocytes to produce TNF, lymphotoxin, interleukin 6, and alpha- and beta-interferons. Thus, stimulation by endotoxin and virus activated distinct, yet overlapping, sets of cytokine genes. We propose that astrocytes and the cytokines they produce may play a significant role in the pathogenesis of immunologically and/or virally mediated CNS disease, in CNS intercellular communication, and in the interactions between the nervous and immune systems.
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Cited by
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Inflammatory cytokines in depression: neurobiological mechanisms and therapeutic implications
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Neurologic disease induced in transgenic mice by cerebral overexpression of interleukin 6.
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Inflammatory Mediators and Stroke: New Opportunities for Novel Therapeutics
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Metadata
- Authors
- Lieberman, A. P., Pitha, P. M., Shin, H. S., & Shin, M. L.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-08
- Volume
- 86
- Issue
- 16
- Pages
- 6348-6352
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069132198
- Cited by
- 783
- References
- 37
- FWCI
- 18.73
- Type
- journal article
- Language
- en
- Open access
- green
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- Lieberman, A. P., Pitha, P. M., Shin, H. S., & Shin, M. L. (1989). Production of tumor necrosis factor and other cytokines by astrocytes stimulated with lipopolysaccharide or a neurotropic virus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.16.6348
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
