Dopamine D2 receptors in the cerebral cortex: Distribution and pharmacological characterization with [3H]raclopride
Open accessAbstract
An apparent involvement of dopamine in the regulation of cognitive functions and the recognition of a widespread dopaminergic innervation of the cortex have focused attention on the identity of cortical dopamine receptors. However, only the presence and distribution of dopamine D1 receptors in the cortex have been well documented. Comparable information on cortical D2 sites is lacking. We report here the results of binding studies in the cortex and neostriatum of rat and monkey using the D2 selective antagonist [3H]raclopride. In both structures [3H]raclopride bound in a sodium-dependent and saturable manner to a single population of sites with pharmacological profiles of dopamine D2 receptors. D2 sites were present in all regions of the cortex, although their density was much lower than in the neostriatum. The density of these sites in both monkey and, to a lesser extent, rat cortex displayed a rostral-caudal gradient with highest concentrations in the prefrontal and lowest concentrations in the occipital cortex, corresponding to dopamine levels in these areas. Thus, the present study establishes the presence and widespread distribution of dopamine D2 receptors in the cortex.
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D2 receptors are less prevalent in monkey dorsolateral PFC and are concentrated on layer V neurons, the layer that projects to striatum and the superior colliculus.
“The D2 receptors are less prevalent in monkey dorsolateral PFC and are concentrated on layer V neurons, the layer that projects to striatum and the superior colliculus (98,122,123).”
From Catecholamine Influences on Dorsolateral Prefrontal Cortical Networks (2011) · cites this paper as [122]
The Discussion reports that D2 binding sites are considerably less concentrated in primate cortex than in the neostriatum, and the Results report binding in monkey prefrontal cortex. The paper does not establish that receptors are concentrated on layer V neurons or identify layer V projections to the striatum and superior colliculus; it measures binding by cortical region, not neuronal layer. (LLM, conf=0.86)
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- [8]Palacios, J. M. & Pazos, A. (1987) in Dopamine Receptors, eds. Creese, I. & Fraser, C. M. (Liss, New York), pp. 175–197.
- [9]Lidow, M. S., Goldman-Rakic, P. S., Gallager, D. W., Geschwind, D. & Rakic, P. (1989) Neuroscience, in press.
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- Authors
- Lidow, M. S., Goldman-Rakic, P. S., Rakic, P., & Innis, R. B.
- Affiliations
- Yale University (US)
- Section of Neuroanatomy, Yale University, School of Medicine, New Haven, CT 06510.
- ORCID
- Rakic, P
- Venue
- Proceedings of the National Academy of Sciences
- Publisher
- National Academy of Sciences
- Published
- 1989-08
- Volume
- 86
- Issue
- 16
- Pages
- 6412-6416
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- PMC
- PMC297850
- OpenAlex
- W1983358193
- Cited by
- 209
- References
- 0
- Citations by year
- 2025: 3 · 2024: 4 · 2023: 7 · 2022: 2 · 2021: 6 · 2020: 8 · 2019: 5 · 2018: 8 · 2017: 4 · 2016: 4 · 2015: 5 · 2014: 6 · 2012: 5
- FWCI
- 3.58
- Type
- journal article
- Language
- en
- Open access
- green
- europepmc.org
- Locations
- Proceedings of the National Academy of Sciences (publishedVersion)
- Europe PMC (PubMed Central) (publishedVersion)
- PubMed Central (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Receptor Mechanisms and Signaling
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neuroscience and Neuropharmacology Research
- Keywords
- dopamine D2 receptor, cerebral cortex, receptor distribution, neostriatum, dopamine receptor density, rostral-caudal gradient, prefrontal cortex, occipital cortex, dopamine levels, rats, monkeys, cognitive function
- MeSH terms
- Animals, Binding, Competitive, Calcium, Cerebral Cortex, Corpus Striatum, Female, Kinetics, Macaca mulatta, Magnesium, Male, Rats, Inbred Strains, Receptors, Dopamine, Receptors, Cell Surface, Salicylamides, Sodium, Thermodynamics, Receptors, Dopamine D2, Raclopride, Rats
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