Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression
Abstract
Background Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. The aim of the present study was to measure striatal D(2) receptor availability and amphetamine-induced dopamine release in nonpsychotic, unmedicated, unipolar patients during an episode of major depression.Methods The striatal equilibrium specific to nonspecific partition coefficient (V(3)") of the D(2) receptor antagonist [(123)I]IBZM was measured with single photon emission computerized tomography before and after amphetamine administration in 9 depressed subjects and 10 matched healthy control subjects.Results No significant differences were observed in preamphetamine D(2) receptor availability between depressed patients (0.73 +/- 0.08) and control subjects (0.78 +/- 0.10, p =.23). Amphetamine-induced reduction in [(123)I]IBZM V(3)" (DeltaV(3)") was similar in depressed patients (-9.8 +/- 5.5%) and control subjects (-7.8 +/- 2.5%, p =.32). Amphetamine induced a transient improvement in symptomatology in depressed patients, but this improvement did not correlate with [(123)I]IBZM DeltaV(3)".Conclusions This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression.
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Molecular-imaging studies of DA signaling in MDD indicate increased D2 receptor binding in the basal ganglia, striatum, and putamen, whereas other studies report lower or no difference in striatal D2 transporter binding potential.
“These studies have indicated increased D2 receptor binding in the basal ganglia [257], striatum [258,259], and putamen [260], whereas other studies have reported lower [261] or no difference [259,262,263] in striatal D2 transporter binding potential.”
From Reward circuitry dysfunction in psychiatric and neurodevelopmental disorders and genetic syndromes: animal models and clinical findings (2012) · cites this paper as [259]
Cites
Hamilton, M. (1960) · Journal of Neurology, Neurosurgery & Psychiatry · doi:10.1136/jnnp.23.1.56 · Cited by 32,817 · see citing works
The Brief Psychiatric Rating Scale.
Overall, J. E., & Gorham, D. R. (1962) · Psychological Reports · doi:10.2466/pr0.1962.10.3.799 · Cited by 11,090 · see citing works
The Structured Clinical Interview for DSM-III-R (SCID): I: History, Rationale, and Description
Spitzer, R. L. (1992) · Archives of General Psychiatry · doi:10.1001/archpsyc.1992.01820080032005 · Cited by 4,336 · see citing works
Psychopharmacology: The Fourth Generation of Progress
Bloom, F. E., & Kupfer, D. J. (1995) · Medical Entomology and Zoology · Cited by 2,985 · see citing works
From motivation to action: Functional interface between the limbic system and the motor system
MOGENSON, G., JONES, D., & YIM, C. (1980) · Progress in Neurobiology · doi:10.1016/0301-0082(80)90018-0 · Cited by 2,331 · see citing works
Negative Symptoms in Schizophrenia: Definition and Reliability
Andreasen, N. C. (1982) · Archives of General Psychiatry · doi:10.1001/archpsyc.1982.04290070020005 · Cited by 2,247 · see citing works
Wise, R. A., & Rompre, P.-P. (1989) · Annual Review of Psychology · doi:10.1146/annurev.ps.40.020189.001203 · Cited by 1,968 · see citing works
Rapid Automated Algorithm for Aligning and Reslicing PET Images
Woods, R. P., Cherry, S. R., & Mazziotta, J. C. (1992) · Journal of Computer Assisted Tomography · doi:10.1097/00004728-199207000-00024 · Cited by 1,932 · see citing works
Laruelle, M., Abi-Dargham, A., van Dyck, C. H., Gil, R., D'Souza, C. D., Erdos, J., McCance, E., Rosenblatt, W., Fingado, C., Zoghbi, S. S., et al. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.17.9235 · Cited by 1,291 · see citing works
Self-citationChronic mild stress-induced anhedonia: A realistic animal model of depression
Willner, P., Muscat, R., & Papp, M. (1992) · Neuroscience & Biobehavioral Reviews · doi:10.1016/s0149-7634(05)80194-0 · Cited by 1,160 · see citing works
Breier, A., Su, T.-P., Saunders, R., Carson, R. E., Kolachana, B. S., de Bartolomeis, A., Weinberger, D. R., Weisenfeld, N., Malhotra, A. K., Eckelman, W. C., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.6.2569 · Cited by 1,154 · see citing works
Increased baseline occupancy of D <sub>2</sub> receptors by dopamine in schizophrenia
Abi-Dargham, A., Rodenhiser, J., Printz, D., Zea-Ponce, Y., Gil, R., Kegeles, L. S., Weiss, R., Cooper, T. B., Mann, J. J., Van Heertum, R. L., et al. (2000) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.97.14.8104 · Cited by 1,020 · see citing works
Self-citationLaruelle, M. (2000) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/00004647-200003000-00001 · Cited by 944 · see citing works
Self-citationReward processing in primate orbitofrontal cortex and basal ganglia
Schultz, W. (2000) · Cerebral Cortex · doi:10.1093/cercor/10.3.272 · Cited by 942 · see citing works
Increased striatal dopamine transmission in schizophrenia: confirmation in a second cohort.
Abi-Dargham, A., Gil, R. B., Krystal, J., Baldwin, R., Seibyl, J., Bowers, M., van Dyck, C., Charney, D., Innis, R., & Laruelle, M. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.6.761 · Cited by 860 · see citing works
Self-citationDecreased striatal dopaminergic responsiveness in detoxified cocaine-dependent subjects
Volkow, N. D., Wang, G.-J., Fowler, J. S., Logan, J., Gatley, S. J., Hitzemann, R., Chen, A. D., Dewey, S. L., & Pappas, N. (1997) · Nature · doi:10.1038/386830a0 · Cited by 854 · see citing works
Increased dopamine transmission in schizophrenia: relationship to illness phases.
Laruelle, M., Abi-Dargham, A., Gil, R. B., Kegeles, L., & Innis, R. (1999) · Biological Psychiatry · doi:10.1016/s0006-3223(99)00067-0 · Cited by 744 · see citing works
Self-citationMalison, R. T., Price, L. H., Berman, R., van Dyck, C. H., Pelton, G. H., Carpenter, L., Sanacora, G., Owens, M. J., Nemeroff, C. B., Rajeevan, N., et al. (1998) · Biological Psychiatry · doi:10.1016/s0006-3223(98)00272-8 · Cited by 496 · see citing works
Kegeles, L., Abi-Dargham, A., Zea-Ponce, Y., Rodenhiser-Hill, J., Mann, J., Heertum, R. V. V., Cooper, T. B., Carlsson, A., & Laruelle, M. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)00976-8 · Cited by 425 · see citing works
Self-citationSelective activation of dopamine transmission in the shell of the nucleus accumbens by stress
Kalivas, P. W., & Duffy, P. (1995) · Brain Research · doi:10.1016/0006-8993(95)00013-g · Cited by 395 · see citing works
Carson, R. E., Channing, M. A., Blasberg, R. G., Dunn, B. B., Cohen, R. M., Rice, K. C., & Herscovitch, P. (1993) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1038/jcbfm.1993.6 · Cited by 376 · see citing works
Brown, A. S., & Gershon, S. (1993) · Journal of Neural Transmission · doi:10.1007/bf01245227 · Cited by 359 · see citing works
Role of the dopaminergic system in depression
Kapur, S., & Mann, J. J. (1992) · Biological Psychiatry · doi:10.1016/0006-3223(92)90137-o · Cited by 350 · see citing works
Self-citationSPECT imaging of striatal dopamine release after amphetamine challenge.
Laruelle, M. A., Abi‐Dargham, A., van Dyck, C. H., Rosenblatt, W., Zea‐Ponce, Y., Zoghbi, S. S., Baldwin, R. M., Charney, D. S., Hoffer, P. B., & Kung, H. F. (1995) · PubMed · Cited by 333 · see citing works
Self-citationLow Dopamine D 2 Receptor Binding Potential in Social Phobia
Schneier, F. R., Liebowitz, M. R., Abi‐Dargham, A., Zea‐Ponce, Y., Lin, S., & Laruelle, M. A. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.3.457 · Cited by 325 · see citing works
Self-citationDeutch, A. Y., Clark, W. A., & Roth, R. H. (1990) · Brain Research · doi:10.1016/0006-8993(90)91557-w · Cited by 302 · see citing works
Sulzer, D. L., Maidment, N. T., & Rayport, S. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03181.x · Cited by 292 · see citing works
Current Developments in Psychopharmacology
Essman, W. B., & Valzelli, L. (1981) · Springer eBooks · doi:10.1007/978-94-011-8123-5 · Cited by 291 · see citing works
Striatal D2 dopamine receptor binding characteristics in vivo in patients with alcohol dependence
Hietala, J., West, C., Syvälahti, E., Någren, K., Lehikoinen, P., Sonninen, P., & Ruotsalainen, U. (1994) · Psychopharmacology · doi:10.1007/bf02245330 · Cited by 269 · see citing works
Imaging D2 Receptor Occupancy by Endogenous Dopamine in Humans
Laruelle, M. (1997) · Neuropsychopharmacology · doi:10.1016/s0893-133x(97)00043-2 · Cited by 266 · see citing works
Self-citationMicrodialysis and SPECT measurements of amphetamine-induced dopamine release in nonhuman primates
Laruelle, M. A., Iyer, R. N., Al‐Tikriti, M. S., Zea‐Ponce, Y., Malison, R. T., Zoghbi, S. S., Baldwin, R. M., Kung, H. F., Charney, D. S., Hoffer, P. B., et al. (1997) · Synapse · doi:10.1002/(sici)1098-2396(199701)25:1 · Cited by 264 · see citing works
Self-citationBrain SPECT Imaging of Amphetamine-Induced Dopamine Release in Euthymic Bipolar Disorder Patients
Anand, A., Verhoeff, P., Seneca, N., Zoghbi, S. S., Seibyl, J. P., Charney, D. S., & Innis, R. B. (2000) · American Journal of Psychiatry · doi:10.1176/appi.ajp.157.7.1108 · Cited by 222 · see citing works
D2 dopamine receptors and personality traits
Farde, L., Gustavsson, P. J., & Jönsson, E. G. (1997) · Nature · doi:10.1038/385590a0 · Cited by 217 · see citing works
The role of dopamine in mood disorders
Diehl, D. J., & Gershon, S. (1992) · Comprehensive Psychiatry · doi:10.1016/0010-440x(92)90007-d · Cited by 216 · see citing works
Lidow, M. S., Goldman-Rakic, P. S., Rakic, P., & Innis, R. B. (1989) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.86.16.6412 · Cited by 209 · see citing works
Dopamine D2 receptors in depression measured with single photon emission computed tomography
D'haenen, H. A., & Bossuyt, A. (1994) · Biological Psychiatry · doi:10.1016/0006-3223(94)91202-5 · Cited by 189 · see citing works
Striatal dopamine transporter density in major depression
Laasonen-Balk, T., Kuikka, J. T., Viinam�ki, H., Husso, M., Lehtonen, J., & Tiihonen, J. (1999) · Psychopharmacology · doi:10.1007/s002130051005 · Cited by 172 · see citing works
Clinical and psychometric correlates of dopamine D<sub>2</sub> binding in depression
SHAH, P. J., OGILVIE, A. D., GOODWIN, G. M., & EBMEIER, K. P. (1997) · Psychological Medicine · doi:10.1017/s0033291797005382 · Cited by 170 · see citing works
Ebert, D., Loew, T. H., Feistel, H., & Pirner, A. (1996) · Psychopharmacology · doi:10.1007/bf02246416 · Cited by 133 · see citing works
Klimke, A. (1999) · Psychiatry Research Neuroimaging · doi:10.1016/s0925-4927(99)00009-8 · Cited by 126 · see citing works
Dopamine D2 Receptor Density and Personal Detachment in Healthy Subjects
Breier, A. F., Kestler, L. J., Adler, C. M., Elman, I., Wiesenfeld, N., Malhotra, A. K., & Pickar, D. (1998) · American Journal of Psychiatry · doi:10.1176/ajp.155.10.1440 · Cited by 119 · see citing works
Samuelsson, B., Ramwell, P. W., Paoletti, R., Folco, G., Granström, E., & Nicosia, S. (1996) · Biomedicine & Pharmacotherapy · doi:10.1016/0753-3322(96)85115-8 · Cited by 111 · see citing works
Laruelle, M. A., van Dyck, C., Abi‐Dargham, A., Zea‐Ponce, Y., Ss, Z., Ds, C., Rm, B., Hoffer, P. B., Hf, K., & Rb, I. (1994) · PubMed · Cited by 92 · see citing works
Self-citationKung, H. F., Kasliwal, R., Pan, S., Kung, M. P., Mach, R. H., & Guo, Y. Z. (1988) · Journal of Medicinal Chemistry · doi:10.1021/jm00400a027 · Cited by 84 · see citing works
Stability of [123I]IBZM SPECT measurement of amphetamine-induced striatal dopamine release in humans
Kegeles, L. S., Zea‐Ponce, Y., Abi‐Dargham, A., Rodenhiser, J., Wang, T., Weiss, R., Heertum, R. L. V., Mann, J. J., & Laruelle, M. (1999) · Synapse · doi:10.1002/(sici)1098-2396(19990315)31:4 · Cited by 80 · see citing works
Dynamic SPECT imaging of dopamine D2 receptors in human subjects with iodine-123-IBZM.
Seibyl, J. P., Sw, W., Ss, Z., Rm, B., Hm, D., Goddard, A. W., Zea‐Ponce, Y., Zubal, G. I., Germine, M., & Eo, S. (1992) · PubMed · Cited by 66 · see citing works
Self-citationPrediction of imipramine antidepressant response by a one-day dextro- amphetamine trial
van Kammen, D. P., & Murphy, D. L. (1978) · American Journal of Psychiatry · doi:10.1176/ajp.135.10.1179 · Cited by 56 · see citing works
Imaging Studies of Cocaine in the Human Brain and Studies of the Cocaine Addicta
Volkow, N. D., Wang, G., & Fowler, J. S. (1997) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.1997.tb46188.x · Cited by 52 · see citing works
Unchanged density of caudate nucleus dopamine uptake sites in depressed suicide victims
Allard, P. O., & Norl�n, M. (1997) · Journal of Neural Transmission · doi:10.1007/bf01294736 · Cited by 16 · see citing works
Synthesis of [123I]IBZM: a reliable procedure for routine clinical studies
Zea‐Ponce, Y., & Laruelle, M. (1999) · Nuclear Medicine and Biology · doi:10.1016/s0969-8051(99)00031-1 · Cited by 12 · see citing works
Self-citation
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Sorted by citations
The Dopamine Hypothesis of Schizophrenia: Version III--The Final Common Pathway
Howes, O. D., & Kapur, S. (2009) · Schizophrenia Bulletin · doi:10.1093/schbul/sbp006 · Cited by 2,693 · see citing works
Reconsidering anhedonia in depression: Lessons from translational neuroscience
Treadway, M. T., & Zald, D. H. (2011) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2010.06.006 · Cited by 1,579 · see citing works
Neuroimaging studies of mood disorders
Drevets, W. C. (2000) · Biological Psychiatry · doi:10.1016/s0006-3223(00)01020-9 · Cited by 1,313 · see citing works
The role of dopamine in the pathophysiology of depression
Dunlop, B. W., & Nemeroff, C. B. (2007) · Archives of General Psychiatry · doi:10.1001/archpsyc.64.3.327 · Cited by 1,244 · see citing works
Martinez, D., Slifstein, M., Broft, A., Mawlawi, O., Hwang, D.-R., Huang, Y., Cooper, T., Kegeles, L., Zarahn, E., Abi-Dargham, A., et al. (2003) · Journal of Cerebral Blood Flow & Metabolism · doi:10.1097/01.wcb.0000048520.34839.1a · Cited by 569 · see citing works
Self-citationInflammation Effects on Motivation and Motor Activity: Role of Dopamine
Felger, J. C., & Treadway, M. T. (2016) · Neuropsychopharmacology · doi:10.1038/npp.2016.143 · Cited by 453 · see citing works
Glutamate, Dopamine, and Schizophrenia: From Pathophysiology to Treatment
LARUELLE, M., KEGELES, L. S., & ABI‐DARGHAM, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1196/annals.1300.063 · Cited by 437 · see citing works
Self-citationNeurobiology of chronic mild stress: parallels to major depression
Hill, M. N., Hellemans, K. G. C., Verma, P., Gorzalka, B. B., & Weinberg, J. (2012) · Neuroscience & Biobehavioral Reviews · doi:10.1016/j.neubiorev.2012.07.001 · Cited by 420 · see citing works
Neurobiology of Dopamine in Schizophrenia
Guillin, O., Abi‐Dargham, A., & Laruelle, M. (2007) · International Review of Neurobiology · doi:10.1016/s0074-7742(06)78001-1 · Cited by 365 · see citing works
Self-citationReview: Glutamate and dopamine dysregulation in schizophrenia — a synthesis and selective review
Stone, J., Morrison, P., & Pilowsky, L. (2007) · Journal of Psychopharmacology · doi:10.1177/0269881106073126 · Cited by 392 · see citing works
Tremblay, L. K., Naranjo, C. A., Graham, S. J., Herrmann, N., Mayberg, H. S., Hevenor, S., & Busto, U. E. (2005) · Archives of General Psychiatry · doi:10.1001/archpsyc.62.11.1228 · Cited by 340 · see citing works
Dichter, G. S., Damiano, C. A., & Allen, J. A. (2012) · Journal of Neurodevelopmental Disorders · doi:10.1186/1866-1955-4-19 · Cited by 299 · see citing works
Dopamine hypothesis of schizophrenia: Making sense of it all
Toda, M., & Abi-Dargham, A. (2007) · Current Psychiatry Reports · doi:10.1007/s11920-007-0041-7 · Cited by 235 · see citing works
Davis, M. T., Holmes, S. E., Pietrzak, R. H., & Esterlis, I. (2017) · Chronic Stress · doi:10.1177/2470547017710916 · Cited by 176 · see citing works
Dopaminergic-based pharmacotherapies for depression
Papakostas, G. I. (2006) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2005.12.002 · Cited by 168 · see citing works
Dynamics of the dopaminergic system as a key component to the understanding of depression
Yadid, G., & Friedman, A. (2008) · Progress in brain research · doi:10.1016/s0079-6123(08)00913-8 · Cited by 160 · see citing works
Meyer, J. H., McNeely, H. E., Sagrati, S., Boovariwala, A., Martin, K., Verhoeff, N. P. L. G., Wilson, A. A., & Houle, S. (2006) · American Journal of Psychiatry · doi:10.1176/ajp.2006.163.9.1594 · Cited by 160 · see citing works
Dopamine D2-Like Receptors and the Antidepressant Response
Gershon, A. A., Vishne, T. H., & Grunhaus, L. J. (2006) · Biological Psychiatry · doi:10.1016/j.biopsych.2006.05.031 · Cited by 159 · see citing works
Narendran, R., Hwang, D., Slifstein, M., Talbot, P., Erritzoe, D., Huang, Y., Cooper, T. B., Martinez, D., Kegeles, L. S., Abi-Dargham, A., et al. (2004) · Synapse · doi:10.1002/syn.20013 · Cited by 156 · see citing works
Self-citationBrain Imaging Studies in Mood and Anxiety Disorders
Anand, A., & Shekhar, A. (2003) · Annals of the New York Academy of Sciences · doi:10.1111/j.1749-6632.2003.tb07095.x · Cited by 155 · see citing works
Pre-synaptic striatal dopaminergic function in people at high risk of psychosis
Howes, O., Montgomery, A., Asselin, M., Murray, R., Grasby, P., & McGuire, P. (2007) · The British journal of psychiatry. Supplement · doi:10.1192/bjp.191.51.s13 · Cited by 159 · see citing works
Acute prefrontal rTMS increases striatal dopamine to a similar degree as D-amphetamine
Pogarell, O., Koch, W., Pöpperl, G., Tatsch, K., Jakob, F., Mulert, C., Grossheinrich, N., Rupprecht, R., Möller, H.-J., Hegerl, U., et al. (2007) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.05.002 · Cited by 133 · see citing works
Abi-Dargham, A., Kegeles, L. S., Zea-Ponce, Y., Mawlawi, O., Martinez, D., Mitropoulou, V., O'Flynn, K., Koenigsberg, H. W., Van Heertum, R., Cooper, T., et al. (2004) · Biological Psychiatry · doi:10.1016/j.biopsych.2004.01.018 · Cited by 128 · see citing works
Self-citationNikolaus, S., Antke, C., & Müller, H. (2009) · Behavioural Brain Research · doi:10.1016/j.bbr.2009.06.009 · Cited by 137 · see citing works
Is depression associated with dysfunction of the central reward system?
Martin-Söelch, C. (2009) · Biochemical Society Transactions · doi:10.1042/bst0370313 · Cited by 123 · see citing works
Cannon, D. M., Klaver, J. M., Peck, S. A., Rallis, D., Erickson, K., & Drevets, W. C. (2008) · Neuropsychopharmacology · doi:10.1038/npp.2008.194 · Cited by 119 · see citing works
Peciña, M., Sikora, M., Avery, E. T., Heffernan, J., Peciña, S., Mickey, B., & Zubieta, J. (2017) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2017.08.427 · Cited by 107 · see citing works
Seneca, N., Finnema, S. J., Farde, L., Gulyás, B., Wikström, H. V., Halldin, C., & Innis, R. B. (2006) · Synapse · doi:10.1002/syn.20238 · Cited by 110 · see citing works
Balottin, U., Fusar‐Poli, P., Termine, C., Molteni, S., & Galli, F. (2012) · Cephalalgia · doi:10.1177/0333102412468386 · Cited by 105 · see citing works
Roiser, J. P., McLean, A., Ogilvie, A. D., Blackwell, A. D., Bamber, D. J., Goodyer, I., Jones, P. B., & Sahakian, B. J. (2005) · Neuropsychopharmacology · doi:10.1038/sj.npp.1300659 · Cited by 96 · see citing works
NMDA antagonist effects on striatal dopamine release: Positron emission tomography studies in humans
Kegeles, L., Martinez, D., Kochan, L., Hwang, D., Huang, Y., Mawlawi, O., Suckow, R., Heertum, R. V. V., & Laruelle, M. (2002) · Synapse · doi:10.1002/syn.10010 · Cited by 106 · see citing works
Self-citationStriatal structure and function in mood disorders: a comprehensive review
Marchand, W. R., & Yurgelun‐Todd, D. (2010) · Bipolar Disorders · doi:10.1111/j.1399-5618.2010.00874.x · Cited by 91 · see citing works
A preliminary PET evaluation of the new dopamine D2 receptor agonist [11C]MNPA in cynomolgus monkey.
Finnema, S., Seneca, N., Farde, L., Shchukin, E., Sóvágó, J., Gulyás, B., Wikström, H., Innis, R., Neumeyer, J., & Halldin, C. (2005) · Nuclear Medicine and Biology · doi:10.1016/j.nucmedbio.2005.01.007 · Cited by 86 · see citing works
Woodward, N. D., Cowan, R. L., Park, S., Ansari, M. S., Baldwin, R. M., Li, R., Doop, M., Kessler, R. M., & Zald, D. H. (2011) · American Journal of Psychiatry · doi:10.1176/appi.ajp.2010.10020165 · Cited by 90 · see citing works
Influences of dopaminergic system dysfunction on late-life depression
Taylor, W. D., Zald, D. H., Felger, J. C., Christman, S., Claassen, D. O., Horga, G., Miller, J. M., Gifford, K., Rogers, B., Szymkowicz, S. M., et al. (2022) · Molecular Psychiatry · doi:10.1038/s41380-021-01265-0 · Cited by 89 · see citing works
Striatal Dopamine in Bulimia Nervosa: a PET Imaging Study
Broft, A., Shingleton, R., Kaufman, J., Liu, F., Kumar, D. J. S., Slifstein, M., Abi-Dargham, A., Schebendach, J., Heertum, R. V. V., Attia, E., et al. (2012) · International Journal of Eating Disorders · doi:10.1002/eat.20984 · Cited by 84 · see citing works
Neuropsychiatric Adverse Effects of Amphetamine and Methamphetamine
Harro, J. (2015) · International review of neurobiology · doi:10.1016/bs.irn.2015.02.004 · Cited by 84 · see citing works
A critique of the dopamine hypothesis of schizophrenia and psychosis.
Moncrieff, J. (2009) · Harvard Review of Psychiatry · doi:10.1080/10673220902979896 · Cited by 90 · see citing works
Kuroda, Y., Motohashi, N., Ito, H., Ito, S., Takano, A., Nishikawa, T., & Suhara, T. (2006) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.03.029 · Cited by 77 · see citing works
“There have been a few studies that compared BP obtained with [I]iodobenzamide (IBZM) in depressed patients with that in age-matched healthy controls (D'haenen and Bossuyt, 1994; Ebert et al., 1994, 1996; Shah et al., 1997; Klimke et al., 1999; Parsey et al., 2001).”
ResultTreadway, M. T., & Pizzagalli, D. A. (2014) · Biology of Mood & Anxiety Disorders · doi:10.1186/2045-5380-4-5 · Cited by 75 · see citing works
Contributions from brain imaging to the elucidation of pathophysiology of bipolar disorder
Soares, J. C. (2003) · The International Journal of Neuropsychopharmacology · doi:10.1017/s1461145703003390 · Cited by 75 · see citing works
Abi-Dargham, A., Kegeles, L., Martinez, D., Innis, R., & Laruelle, M. (2003) · European Neuropsychopharmacology · doi:10.1016/j.euroneuro.2003.08.007 · Cited by 73 · see citing works
Self-citationDopamine overflow is increased in olfactory bulbectomized rats: an in vivo microdialysis study
Masini, C. V., Holmes, P. V., Freeman, K. G., Maki, A. C., & Edwards, G. L. (2004) · Physiology & Behavior · doi:10.1016/j.physbeh.2004.01.003 · Cited by 71 · see citing works
Hirvonen, J., Karlsson, H., Kajander, J., Markkula, J., Rasi-Hakala, H., Någren, K., Salminen, J. K., & Hietala, J. A. (2008) · Psychopharmacology · doi:10.1007/s00213-008-1088-9 · Cited by 69 · see citing works
Yang, Y. K., Yeh, T. L., Yao, W. J., Lee, I. H., Chen, P. S., Chiu, N.-T., & Lu, R. B. (2008) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2007.08.008 · Cited by 69 · see citing works
Slifstein, M., Narendran, R., Hwang, D., Sudo, Y., Talbot, P., Huang, Y., & Laruelle, M. (2004) · Synapse · doi:10.1002/syn.20062 · Cited by 73 · see citing works
Self-citationJobson, C. L. M., Renard, J., Szkudlarek, H., Rosen, L. G., Pereira, B., Wright, D. J., Rushlow, W., & Laviolette, S. R. (2019) · Cerebral Cortex · doi:10.1093/cercor/bhy179 · Cited by 64 · see citing works
Dougherty, D. D., Bonab, A. A., Ottowitz, W. E., Livni, E., Alpert, N. M., Rauch, S. L., D, M. F. M., & Fischman, A. J. (2006) · Depression and Anxiety · doi:10.1002/da.20168 · Cited by 64 · see citing works
The Neurobiology of Motivational Deficits in Depression—An Update on Candidate Pathomechanisms
Treadway, M. T. (2015) · Current topics in behavioral neurosciences · doi:10.1007/7854_2015_400 · Cited by 63 · see citing works
WINCS Harmoni: Closed-loop dynamic neurochemical control of therapeutic interventions
Lee, K. H., Luján, J. L., Trevathan, J. K., Ross, E. K., Bartoletta, J. J., Park, H. O., Paek, S. B., Nicolai, E. N., Lee, J. H., Min, H.-K. P., et al. (2017) · Scientific Reports · doi:10.1038/srep46675 · Cited by 64 · see citing works
Hamilton, J. P., Sacchet, M., Hjørnevik, T., Chin, F. T., Shen, B., Kämpe, R., Park, J. H., Knutson, B., Williams, L., Borg, N., et al. (2018) · Translational Psychiatry · doi:10.1038/s41398-018-0316-2 · Cited by 61 · see citing works
Xiang, L., Szebeni, K., Szebeni, A., Klimek, V., Stockmeier, C. A., Karolewicz, B., Kalbfleisch, J. H., & Ordway, G. A. (2008) · Brain Research · doi:10.1016/j.brainres.2008.02.009 · Cited by 60 · see citing works
Montgomery, A. J., Stokes, P. R. A., Kitamura, Y., & Grasby, P. M. (2007) · Journal of Affective Disorders · doi:10.1016/j.jad.2006.11.010 · Cited by 58 · see citing works
Reduced striatal D2 receptor binding in myoclonus–dystonia
Beukers, R. J., Booij, J., Weisscher, N., Zijlstra, F., van Amelsvoort, T., & Tijssen, M. A. J. (2008) · European Journal of Nuclear Medicine and Molecular Imaging · doi:10.1007/s00259-008-0924-9 · Cited by 58 · see citing works
Laviolette, S. R. (2021) · Neuropharmacology · doi:10.1016/j.neuropharm.2020.108411 · Cited by 57 · see citing works
Rocca, P., Leo, C. D., Eva, C. E., Marchiaro, L., Milani, A. M., Musso, R., Ravizza, L., Zanalda, E., & Bogetto, F. (2002) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/s0278-5846(02)00253-1 · Cited by 57 · see citing works
Mizuno, Y., Ashok, A. H., Bhat, B. B., Jauhar, S., & Howes, O. D. (2023) · Journal of Psychopharmacology · doi:10.1177/02698811231200881 · Cited by 56 · see citing works
Dopaminergic activity in depressed smokers: A positron emission tomography study
Busto, U. E., Redden, L., Mayberg, H. S., Kapur, S., Houle, S., & Zawertailo, L. A. (2009) · Synapse · doi:10.1002/syn.20646 · Cited by 54 · see citing works
Mischoulon, D., Hylek, L., Yeung, A., Clain, A. J., Baer, L., Cusin, C., Ionescu, D. F., Alpert, J. E., Soskin, D. P., & D, M. F. M. (2016) · Journal of Affective Disorders · doi:10.1016/j.jad.2016.08.029 · Cited by 55 · see citing works
Striatal dopamine type 2 receptor availability in anorexia nervosa
Broft, A. I., Slifstein, M., Osborne, J. R., Kothari, P. J., Morim, S., Shingleton, R. M., Kenney, L., Vallabhajosula, S., Attia, E., Martínez, D., et al. (2015) · Psychiatry Research Neuroimaging · doi:10.1016/j.pscychresns.2015.06.013 · Cited by 53 · see citing works
Dopamine Transmission in the Schizophrenic Brain
Laruelle, M. A. (2003) · Wiley eBooks · doi:10.1002/9780470987353.ch20 · Cited by 53 · see citing works
Self-citationNeuropathological changes in the substantia nigra in schizophrenia but not depression
Williams, M. R., Galvin, K., O'Sullivan, B., Macdonald, C., Ching, E. W. K., Turkheimer, F., Howes, O., Pearce, R. K., Hirsch, S., & Maier, M. (2014) · European Archives of Psychiatry and Clinical Neuroscience · doi:10.1007/s00406-013-0479-z · Cited by 51 · see citing works
Rodrigues, A. L. S., Rosa, J. M., Gadotti, V. M., Goulart, E. C., Santos, M. M. M., Silva, A., Sehnem, B., Rosa, L. S., Gonçalves, R. M., Corrêa, R., et al. (2005) · Pharmacology Biochemistry and Behavior · doi:10.1016/j.pbb.2005.08.003 · Cited by 49 · see citing works
A review of the neurobiological underpinning of comorbid substance use and mood disorders
Gómez‐Coronado, N., Sethi, R., Bortolasci, C. C., Arancini, L., Berk, M., & Dodd, S. (2018) · Journal of Affective Disorders · doi:10.1016/j.jad.2018.08.041 · Cited by 48 · see citing works
Moses‐Kolko, E. L., Price, J. C., Wisner, K. L., Hanusa, B. H., MELTZER, C. C., Berga, S. L., Grace, A. A., di Scalea, T. L., Kaye, W. H., Becker, C. R., et al. (2012) · Neuropsychopharmacology · doi:10.1038/npp.2011.328 · Cited by 46 · see citing works
Smith, G. S., Gunning‐Dixon, F. M., Lotrich, F. E., Taylor, W. D., & Evans, J. D. (2007) · Neuropsychopharmacology · doi:10.1038/sj.npp.1301333 · Cited by 45 · see citing works
Anhedonia in Unipolar Major Depressive Disorder: A Review~!2009-10-26~!2010-02-18~!2010-04-08~!
Dichter, G. S. (2010) · The Open Psychiatry Journal · doi:10.2174/1874354401004010001 · Cited by 50 · see citing works
Acute and Chronic Effects of Citalopram on Cerebral Glucose Metabolism in Geriatric Depression
Smith, G. S., Kramer, E., Hermann, C. R., Goldberg, S., Ma, Y., DHAWAN, V. M., Barnes, A., Chaly, T., Belakhleff, A., Laghrissi‐Thode, F., et al. (2002) · American Journal of Geriatric Psychiatry · doi:10.1097/00019442-200211000-00010 · Cited by 44 · see citing works
Laruelle, M. (2012) · Neuromethods · doi:10.1007/7657_2012_45 · Cited by 40 · see citing works
Self-citationPsychiatric disorders and headache familial recurrence: a study on 200 children and their parents
Galli, F., Canzano, L., Scalisi, T. G., & Guidetti, V. (2009) · The Journal of Headache and Pain · doi:10.1007/s10194-009-0105-7 · Cited by 45 · see citing works
Effect of a History of Major Depressive Disorder on Smoking-Induced Dopamine Release
Brody, A. L., Olmstead, R. E., Abrams, A. L., Costello, M. R., Khan, A., Kozman, D. M., Saxena, S., Farahi, J. B., London, E. D., & Mandelkern, M. A. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.06.011 · Cited by 40 · see citing works
Tsai, H.-Y., Chen, K. C., Yang, Y. K., Chen, P. S., Yeh, T. L., Chiu, N.-T., & Lee, I. H. (2010) · Progress in Neuro-Psychopharmacology and Biological Psychiatry · doi:10.1016/j.pnpbp.2010.09.014 · Cited by 39 · see citing works
Recent Advances in the Neurobiology of Depression
Normann, C., & Berger, T. (2003) · CRC Press eBooks · doi:10.3109/9780203002889-3 · Cited by 37 · see citing works
Anhedonia in Unipolar Major Depressive Disorder: A Review
Dichter, G. S. (2010) · The Open Psychiatry Journal · Cited by 36 · see citing works
Schneier, F. R., Slifstein, M., Whitton, A. E., Pizzagalli, D. A., Reinen, J., McGrath, P. J., Iosifescu, D. V., & Abi‐Dargham, A. (2018) · Biological Psychiatry · doi:10.1016/j.biopsych.2018.05.014 · Cited by 36 · see citing works
Key players in major and bipolar depression—A retrospective analysis of in vivo imaging studies
Nikolaus, S., Hautzel, H., Heinzel, A., & Müller, H. (2012) · Behavioural Brain Research · doi:10.1016/j.bbr.2012.03.021 · Cited by 35 · see citing works
Molecular imaging of striatal dopamine transporters in major depression—A meta-analysis
Li, Z., Hé, Y., Tang, J., Zong, X., Hu, M., & Chen, X. (2014) · Journal of Affective Disorders · doi:10.1016/j.jad.2014.11.045 · Cited by 34 · see citing works
Nikolaus, S., Mamlins, E., Hautzel, H., & Müller, H.-W. (2019) · Reviews in the Neurosciences · doi:10.1515/revneuro-2018-0037 · Cited by 35 · see citing works
Penttilä, J., Kajander, J., Aalto, S., Hirvonen, J., Någren, K., Ilonen, T., Syvälahti, E. K. G., & Hietala, J. A. (2004) · The International Journal of Neuropsychopharmacology · doi:10.1017/s146114570400450x · Cited by 32 · see citing works
Positron emission tomography and single photon emission CT molecular imaging in schizophrenia.
Erritzoe, D., Talbot, P., Frankle, W., & Abi-Dargham, A. (2003) · Neuroimaging clinics of North America · doi:10.1016/s1052-5149(03)00089-3 · Cited by 26 · see citing works
Recent advances in the neurobiology of depression
Normann, C., & Berger, T. (2003) · CRC Press eBooks · doi:10.3109/9780203002889-5 · Cited by 30 · see citing works
The emerging biology of delusions
Murray, G. (2010) · Psychological Medicine · doi:10.1017/s0033291710000413 · Cited by 29 · see citing works
Neuroimaging and Neuropathological Studies of Mood Disorders
Drevets, W. C., & Price, J. L. (2005) · Biology of Depression · doi:10.1002/9783527619672.ch17 · Cited by 26 · see citing works
Ng, T. H. J., Sarikahya, M. H., Hudson, R., Szkudlarek, H. J., Pérez-Valenzuela, E., Uzuneser, T. C., Proud, E., Gummerson, D., Youssef, M., Machado, M., et al. (2024) · Neuropsychopharmacology · doi:10.1038/s41386-024-01853-y · Cited by 23 · see citing works
Incentive salience: novel treatment strategies for major depression
Soskin, D. P., Holt, D. J., Sacco, G. R., & D, M. F. M. (2013) · CNS Spectrums · doi:10.1017/s1092852913000345 · Cited by 22 · see citing works
Molecular imaging as a guide for the treatment of central nervous system disorders
Kim, E., Howes, O., & Kapur, S. (2013) · Dialogues in Clinical Neuroscience · doi:10.31887/dcns.2013.15.3/ekim · Cited by 23 · see citing works
Human dopamine receptor D2/D3 availability predicts amygdala reactivity to unpleasant stimuli
Kobiella, A., Vollstädt‐Klein, S., Fauth‐Bühler, M., Graf, C., Buchholz, H., Bernow, N., Yakushev, I. Y., Landvogt, C., Schreckenberger, M., Gründer, G., et al. (2009) · Human Brain Mapping · doi:10.1002/hbm.20900 · Cited by 21 · see citing works
Striatal Dopamine D2/3 Receptor Availability in Treatment Resistant Depression
de Kwaasteniet, B. P., Pinto, C., Ruhé, H. G., van Wingen, G. A., Booij, J., & Denys, D. A. J. P. (2014) · PLoS ONE · doi:10.1371/journal.pone.0113612 · Cited by 21 · see citing works
Functional Neuroimaging in Geriatric Depression
Gunning, F. M., & Smith, G. S. (2011) · Psychiatric Clinics of North America · doi:10.1016/j.psc.2011.02.010 · Cited by 21 · see citing works
Neuroreceptor imaging in psychiatry: theory and applications.
Frankle, W., Slifstein, M., Talbot, P., & Laruelle, M. (2005) · International review of neurobiology · doi:10.1016/s0074-7742(05)67011-0 · Cited by 21 · see citing works
Self-citationPaul, E. R., Östman, L., Heilig, M. A., Mayberg, H. S., & Hamilton, J. P. (2023) · Translational Psychiatry · doi:10.1038/s41398-023-02466-7 · Cited by 16 · see citing works
Girgis, R. R., Slifstein, M., Brucato, G., Kegeles, L. S., Colibazzi, T., Lieberman, J. A., & Abi‐Dargham, A. (2020) · Molecular Psychiatry · doi:10.1038/s41380-020-00934-w · Cited by 17 · see citing works
Self-citationPositron Emission Tomography Molecular Imaging in Late-Life Depression
Hirao, K., & Smith, G. S. (2014) · Journal of Geriatric Psychiatry and Neurology · doi:10.1177/0891988713516540 · Cited by 15 · see citing works
Hurd, Y., & Hall, H. (2005) · Handbook of chemical neuroanatomy · doi:10.1016/s0924-8196(05)80013-2 · Cited by 16 · see citing works
Moses‐Kolko, E. L., MELTZER, C. C., Berga, S. L., & Wisner, K. L. (2008) · Elsevier eBooks · doi:10.1016/b978-0-12-374285-8.00012-3 · Cited by 13 · see citing works
Neuroreceptor Imaging of Stress and Mood Disorders
Kennedy, S. E., & Zubieta, J.-K. (2004) · CNS Spectrums · doi:10.1017/s1092852900009238 · Cited by 12 · see citing works
Ketter, T. A., & Drevets, W. C. (2002) · Clinical Neuroscience Research · doi:10.1016/s1566-2772(02)00043-9 · Cited by 12 · see citing works
Molecular Imaging of Depressive Disorders
Ruhé, H., Visser, A. K. D., Frokjaer, V., Haarman, B., Klein, H., & Booij, J. (2020) · PET and SPECT in Psychiatry · doi:10.1007/978-3-642-40384-2_5 · Cited by 2 · see citing works
Lee, B., Chiu, N.-T., Yang, Y. K., & Chu, C. L. (2007) · Nuclear Medicine Communications · doi:10.1097/mnm.0b013e3280bad8b6 · Cited by 10 · see citing works
How schizophrenia and depression disrupt reward circuitry
Holcomb, H., & Rowland, L. (2007) · Current Treatment Options in Neurology · doi:10.1007/s11940-007-0021-6 · Cited by 8 · see citing works
- Authors
- Parsey, R. V., Oquendo, M. A., Zea-Ponce, Y., Rodenhiser, J., Kegeles, L. S., Pratap, M., Cooper, T. B., Van Heertum, R., Mann, J. J., & Laruelle, M.
- Affiliations
- Columbia University (US)
- New York State Psychiatric Institute (US)
- Columbia University Irving Medical Center (US)
- Corresponding author
- Parsey, Ramin V
- Venue
- Biological Psychiatry
- Publisher
- Elsevier BV
- Published
- 2001-09
- Volume
- 50
- Issue
- 5
- Pages
- 313-322
- ISSN
- 0006-3223 (ISSN-L)
- OpenAlex
- W1976435745
- Cited by
- 133
- References
- 50
- Citations by year
- 2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 9
- FWCI
- 2.94
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Biological Psychiatry (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institute of Mental Health (1K02 MH01603-01, P30MH046745, 2 P30 MH46745-10, K02MH001603)
- National Center for Research Resources (M01RR000645)
- Topics
- Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
- Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
- Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
- Keywords
- amphetamine-induced dopamine release, major depressive disorder, striatum, [123I]IBZM, dopamine transporter imaging, dopamine signaling
- MeSH terms
- Adolescent, Adult, Amphetamine, Benzamides, Corpus Striatum, Major Depressive Disorder, Dopamine, Female, Humans, Iodine Radioisotopes, Male, Middle Aged, Synaptic Transmission, Pyrrolidines, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2
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