Cited by 133Neurotransmitter Receptor Influence on BehaviorTreatment of Major DepressionTryptophan and brain disorders

Dopamine D2 receptor availability and amphetamine-induced dopamine release in unipolar depression

Parsey, Ramin V, Oquendo, Maria A, Zea-Ponce, Yolanda, Rodenhiser, Janine, Kegeles, Lawrence S, Pratap, Mali, Cooper, Thomas B, Van Heertum, Ronald +2 more·2001·Biological Psychiatry

Abstract

Background Reduced dopaminergic transmission has been implicated in the pathophysiology of major depression. The aim of the present study was to measure striatal D(2) receptor availability and amphetamine-induced dopamine release in nonpsychotic, unmedicated, unipolar patients during an episode of major depression.Methods The striatal equilibrium specific to nonspecific partition coefficient (V(3)") of the D(2) receptor antagonist [(123)I]IBZM was measured with single photon emission computerized tomography before and after amphetamine administration in 9 depressed subjects and 10 matched healthy control subjects.Results No significant differences were observed in preamphetamine D(2) receptor availability between depressed patients (0.73 +/- 0.08) and control subjects (0.78 +/- 0.10, p =.23). Amphetamine-induced reduction in [(123)I]IBZM V(3)" (DeltaV(3)") was similar in depressed patients (-9.8 +/- 5.5%) and control subjects (-7.8 +/- 2.5%, p =.32). Amphetamine induced a transient improvement in symptomatology in depressed patients, but this improvement did not correlate with [(123)I]IBZM DeltaV(3)".Conclusions This study did not replicate previously reported alterations in striatal D(2) receptor density in depressed patients and suggests that stimulant-induced dopamine release is not altered in major depression.

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Crossref · 10.1016/s0006-3223(01)01089-7

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Authors
Parsey, R. V., Oquendo, M. A., Zea-Ponce, Y., Rodenhiser, J., Kegeles, L. S., Pratap, M., Cooper, T. B., Van Heertum, R., Mann, J. J., & Laruelle, M.
Affiliations
  • Columbia University (US)
  • New York State Psychiatric Institute (US)
  • Columbia University Irving Medical Center (US)
Corresponding author
Parsey, Ramin V
Venue
Biological Psychiatry
Publisher
Elsevier BV
Published
2001-09
Volume
50
Issue
5
Pages
313-322
ISSN
0006-3223 (ISSN-L)
OpenAlex
W1976435745
Cited by
133
References
50
Citations by year
2026: 1 · 2025: 3 · 2024: 1 · 2023: 2 · 2021: 2 · 2020: 4 · 2019: 2 · 2018: 6 · 2017: 3 · 2016: 3 · 2015: 4 · 2014: 5 · 2013: 5 · 2012: 9
FWCI
2.94
Type
journal article
Language
en
Open access
closed
Locations
  • Biological Psychiatry (publishedVersion)
  • PubMed (publishedVersion)
Funders
  • National Institute of Mental Health (1K02 MH01603-01, P30MH046745, 2 P30 MH46745-10, K02MH001603)
  • National Center for Research Resources (M01RR000645)
Topics
  • Life Sciences › Neuroscience › Cellular and Molecular Neuroscience › Neurotransmitter Receptor Influence on Behavior
  • Health Sciences › Medicine › Pharmacology › Treatment of Major Depression
  • Life Sciences › Neuroscience › Biological Psychiatry › Tryptophan and brain disorders
Keywords
amphetamine-induced dopamine release, major depressive disorder, striatum, [123I]IBZM, dopamine transporter imaging, dopamine signaling
MeSH terms
Adolescent, Adult, Amphetamine, Benzamides, Corpus Striatum, Major Depressive Disorder, Dopamine, Female, Humans, Iodine Radioisotopes, Male, Middle Aged, Synaptic Transmission, Pyrrolidines, Tomography, Emission-Computed, Single-Photon, Receptors, Dopamine D2

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