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5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system.
Open accessAbstract
Neurons in rat central nervous system (CNS) that express 5-HT1c receptor mRNA have been localized by in situ hybridization histochemistry. The 5-HT1c receptor is expressed in a wide variety of cortical and subcortical neurons including hippocampal pyramidal neurons, neurons within most of the central monoaminergic cell groups, neurons in thalamic sensory relay nuclei, and neurons involved in the central processing and regulation of nociceptive transmission. Therefore, the 5-HT1c receptor is a prominent but poorly characterized central subclass of serotonin (5-HT) receptor. The distribution of the 5-HT1c receptor within the CNS is considerably more widespread than that of the structurally and functionally related 5-HT2 receptor.
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Steinbusch, H. W. M. (1981) · Neuroscience · doi:10.1016/0306-4522(81)90146-9 · Cited by 2,415
Cited by
A review of central 5-HT receptors and their function
Barnes, N. M., & Sharp, T. (1999) · Neuropharmacology · doi:10.1016/s0028-3908(99)00010-6 · Cited by 3,161
Millan, M. J. (2002) · Progress in Neurobiology · doi:10.1016/s0301-0082(02)00009-6 · Cited by 3,035
Molecular biology of 5-HT receptors
Boess, F. G., & Martin, I. L. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90059-0 · Cited by 677
Pharmacologic mechanisms of serotonergic regulation of dopamine neurotransmission
Alex, K. D., & Pehek, E. A. (2007) · Pharmacology & Therapeutics · doi:10.1016/j.pharmthera.2006.08.004 · Cited by 658
Peroutka, S. J. (1993) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.1993.tb03166.x · Cited by 521
Metadata
- Authors
- Molineaux, S. M., Jessell, T. M., Axel, R., & Julius, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-09
- Volume
- 86
- Issue
- 17
- Pages
- 6793-6797
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1989352400
- Cited by
- 261
- References
- 1
- FWCI
- 5.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Molineaux, S. M., Jessell, T. M., Axel, R., & Julius, D. (1989). 5-HT1c receptor is a prominent serotonin receptor subtype in the central nervous system. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.17.6793
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
