The DOI matches its Crossref record; 3 of the 3 references it cites were found in a registry or an index.
Conservation of the human telomere sequence (TTAGGG)n among vertebrates.
Open accessAbstract
To determine the evolutionary origin of the human telomere sequence (TTAGGG)n, biotinylated oligodeoxynucleotides of this sequence were hybridized to metaphase spreads from 91 different species, including representative orders of bony fish, reptiles, amphibians, birds, and mammals. Under stringent hybridization conditions, fluorescent signals were detected at the telomeres of all chromosomes, in all 91 species. The conservation of the (TTAGGG)n sequence and its telomeric location, in species thought to share a common ancestor over 400 million years ago, strongly suggest that this sequence is the functional vertebrate telomere.
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Citations
Cites
A telomeric sequence in the RNA of Tetrahymena telomerase required for telomere repeat synthesis
Greider, C. W., & Blackburn, E. H. (1989) · Nature · doi:10.1038/337331a0 · Cited by 1,643
Greider, C. W., & Blackburn, E. H. (1987) · Cell · doi:10.1016/0092-8674(87)90576-9 · Cited by 1,150
DNA sequences of telomeres maintained in yeast
Shampay, J., Szostak, J. W., & Blackburn, E. H. (1984) · Nature · doi:10.1038/310154a0 · Cited by 551
Cited by
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Counter, C. M., Avilion, A. A., LeFeuvre, C. E., Stewart, N. G., Greider, C. W., Harley, C. B., & Bacchetti, S. (1992) · The EMBO Journal · doi:10.1002/j.1460-2075.1992.tb05245.x · Cited by 2,096
Telomere loss: mitotic clock or genetic time bomb?
Harley, C. B. (1991) · Mutation Research/DNAging · doi:10.1016/0921-8734(91)90018-7 · Cited by 1,139
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Kipling, D., & Cooke, H. J. (1990) · Nature · doi:10.1038/347400a0 · Cited by 614
Metadata
- Authors
- Meyne, J., Ratliff, R. L., & Moyzis, R. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-09
- Volume
- 86
- Issue
- 18
- Pages
- 7049-7053
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2020038227
- Cited by
- 843
- References
- 3
- FWCI
- 8.63
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Conservation of the human telomere sequence (TTAGGG)n among vertebrates. https://app.cochat.ai/papers/10.1073/pnas.86.18.7049
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- Meyne, J., Ratliff, R. L., & Moyzis, R. K. (1989). Conservation of the human telomere sequence (TTAGGG)n among vertebrates. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.18.7049
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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