Hypervariable ultra-long telomeres in mice
Abstract
Telomere structure and behaviour is less well understood in vertebrates than it is in ciliates and yeasts (reviewed in ref. 1). Like all other eukaryotic chromosomes, those of vertebrates terminate in an array of a short repeated sequence. In vertebrates this sequence is (TTAGGG)n, as shown by in situ hybridization. In humans, these terminal repeats are heterogeneous in length, averaging about 10 kilobases in blood cells. Here we report the structure and inheritance of the terminal repeats present at mouse telomeres. The (TTAGGG)n tracts are many times larger than those present at human telomeres. Because of their constancy in length through somatic cell divisions, they are resolved as multiple discrete restriction fragments of up to 150 kilobases. Strikingly, this banding pattern is highly polymorphic within populations of inbred mice, suggesting an unusually high mutation rate. Indeed, although the banding pattern is inherited in a largely mendelian fashion, (TTAGGG)n tracts of new size appear frequently in family studies.
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Humans have relatively short telomeres of about 5-15 kilobases, whereas inbred laboratory mice typically have telomeres longer than 40 kilobases.
“Humans have relatively short telomeres of ~5–15 kilobases in comparison to inbred strains of laboratory mice which have telomeres that are typically >40 kilobases (Kipling and Cooke, 1990).”
From Short Telomeres and Stem Cell Exhaustion Model Duchenne Muscular Dystrophy in mdx/mTR Mice (2010) · cites this paper as Kipling and Cooke, 1990
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- Authors
- Kipling, D., & Cooke, H. J.
- Affiliations
- Western General Hospital (GB)
- Venue
- Nature
- Published
- 1990-09-27
- Volume
- 347
- Issue
- 6291
- Pages
- 400-402
- ISSN
- 0028-0836 (ISSN-L)
- 1476-4687
- OpenAlex
- W1986808310
- Cited by
- 614
- References
- 1
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 14 · 2022: 8 · 2021: 12 · 2020: 9 · 2019: 16 · 2018: 14 · 2017: 11 · 2016: 20 · 2015: 19 · 2014: 16 · 2013: 16 · 2012: 21
- FWCI
- 10.49
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- Nature (publishedVersion)
- PubMed (publishedVersion)
- Topics
- Health Sciences › Medicine › Physiology › Telomeres, Telomerase, and Senescence
- Life Sciences › Agricultural and Biological Sciences › Plant Science › Chromosomal and Genetic Variations
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Aging › Genetics, Aging, and Longevity in Model Organisms
- Keywords
- telomeres, TTAGGG repeats, restriction fragment polymorphism, inbred mouse strains
- MeSH terms
- Animals, Chromosomes, DNA, DNA Restriction Enzymes, Humans, Male, Mice, Inbred BALB C, Mice, Inbred CBA, Mice, Inbred C57BL, Mice, Inbred DBA, Nucleic Acid Hybridization, Polymorphism, Genetic, Repetitive Sequences, Nucleic Acid, Mice
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