The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Salmonella typhimurium phoP virulence gene is a transcriptional regulator.
Open accessAbstract
Salmonella typhimurium is a facultative intracellular pathogen capable of surviving within host phagocytic cells. Salmonella strains carrying phoP mutations are avirulent, unable to survive in macrophages, and extremely sensitive to peptides having antimicrobial activity such as the host-derived defensins. We present here the DNA sequence of the phoP gene and show that the deduced amino acid sequence of phoP has extensive homology with the Escherichia coli transcriptional regulators PhoB and OmpR, which control the expression of loci in response to different environmental stimuli. The psiD locus, which is regulated by phosphate availability, was found to be under the control of the phoP gene product. Sequences homologous to phoP were found in several Gram-negative species and in the yeast Saccharomyces cerevisiae.
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Cites
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Cited by
Defensins: antimicrobial peptides of innate immunity
Ganz, T. (2003) · Nature Reviews Immunology · doi:10.1038/nri1180 · Cited by 3,066
The Pleiotropic Two-Component Regulatory System PhoP-PhoQ
Groisman, E. A. (2001) · Journal of Bacteriology · doi:10.1128/jb.183.6.1835-1842.2001 · Cited by 887
Self-citationRecognition of Antimicrobial Peptides by a Bacterial Sensor Kinase
Bader, M. W., Sanowar, S., Daley, M. E., Schneider, A. R., Cho, U., Xu, W., Klevit, R. E., Le Moual, H., & Miller, S. I. (2005) · Cell · doi:10.1016/j.cell.2005.05.030 · Cited by 567
Gunn, J. S. (2008) · Trends in Microbiology · doi:10.1016/j.tim.2008.03.007 · Cited by 332
A PhoP-repressed gene promotes Salmonella typhimurium invasion of epithelial cells
Behlau, I., & Miller, S. I. (1993) · Journal of Bacteriology · doi:10.1128/jb.175.14.4475-4484.1993 · Cited by 270
Metadata
- Authors
- Groisman, E. A., Chiao, E., Lipps, C. J., & Heffron, F.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-09
- Volume
- 86
- Issue
- 18
- Pages
- 7077-7081
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2061645799
- Cited by
- 336
- References
- 1
- FWCI
- 7.33
- Type
- journal article
- Language
- en
- Open access
- green
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- Groisman, E. A., Chiao, E., Lipps, C. J., & Heffron, F. (1989). Salmonella typhimurium phoP virulence gene is a transcriptional regulator. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.18.7077
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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