The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers.
Open accessAbstract
The frequency of recombination between the G gamma-globin (HBG2) and parathyroid hormone (PTH) loci on the short arm of human chromosome 11 was estimated by typing greater than 700 single-sperm samples from two males. The sperm-typing technique employed involves the polymerase chain reaction and allele-specific oligonucleotide hybridization. Our maximum likelihood recombination fraction estimate of 0.16 (95%) confidence interval, 0.13-0.19) falls well within previous estimates based on family studies. With current technology and a sample size of 1000 sperm, recombination fractions down to approximately 0.009 can be estimated with statistical reliability; with a sample size of 5000 sperm, this value drops to about 0.004. Reasonable technological improvements could result in the detection of recombination frequencies less than 0.001.
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Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Saiki, R. K., Scharf, S., Faloona, F., Mullis, K. B., Horn, G. T., Erlich, H. A., & Arnheim, N. (1985) · Science · doi:10.1126/science.2999980 · Cited by 8,956
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Cited by
Treff, N. R., Su, J., Tao, X., Levy, B., & Scott, R. T. (2010) · Fertility and Sterility · doi:10.1016/j.fertnstert.2010.01.052 · Cited by 270
Theoretical uncertainty of measurements using quantitative polymerase chain reaction
Peccoud, J., & Jacob, C. (1996) · Biophysical Journal · doi:10.1016/s0006-3495(96)79205-6 · Cited by 170
Takiyama, Y. (1997) · Human Molecular Genetics · doi:10.1093/hmg/6.7.1063 · Cited by 66
Metadata
- Authors
- Cui, X. F., Li, H. H., Goradia, T. M., Lange, K., Kazazian, H. H., Galas, D., & Arnheim, N.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-12
- Volume
- 86
- Issue
- 23
- Pages
- 9389-9393
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077165754
- Cited by
- 188
- References
- 2
- FWCI
- 3.98
- Type
- journal article
- Language
- en
- Open access
- green
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- Cui, X. F., Li, H. H., Goradia, T. M., Lange, K., Kazazian, H. H., Galas, D., & Arnheim, N. (1989). Single-sperm typing: determination of genetic distance between the G gamma-globin and parathyroid hormone loci by using the polymerase chain reaction and allele-specific oligomers. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.23.9389
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