The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation.
Open accessAbstract
We report that tumor necrosis factor alpha (TNF-alpha) mRNA is increased after treatment with x-rays in certain human sarcoma cells. An increase in TNF-alpha mRNA is accompanied by the increased production of TNF-alpha protein. TNF-alpha enhances radiation lethality in both TNF-alpha-producing and -nonproducing tumor cells. These data suggest that, in addition to the direct cytotoxic effects of x-rays, production of TNF-alpha may add to radiation lethality through autocrine and paracrine mechanisms. Combinations of TNF-alpha and therapeutic radiation may be useful in clinical cancer therapy.
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Citations
Cites
An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Cited by
Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.
Mauch, P., Constine, L., Greenberger, J., Knospe, W., Sullivan, J., Liesveld, J. L., & Deeg, H. J. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)00430-s · Cited by 507
The life, death, and replacement of oligodendrocytes in the adult CNS
McTigue, D. M., & Tripathi, R. B. (2008) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2008.05570.x · Cited by 455
Induction of cellular p53 activity by DNA-damaging agents and growth arrest.
Zhan, Q., Carrier, F., & Fornace, A. J. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.7.4242 · Cited by 441
A Sense of Danger from Radiation1
McBride, W. H., Chiang, C.-S., Olson, J. L., Wang, C.-C., Hong, J.-H., Pajonk, F., Dougherty, G. J., Iwamoto, K. S., Pervan, M., & Liao, Y.-P. (2004) · Radiation Research · doi:10.1667/rr3196 · Cited by 323
Radiation induced CNS toxicity – molecular and cellular mechanisms
Belka, C., Budach, W., Kortmann, R. D., & Bamberg, M. (2001) · British Journal of Cancer · doi:10.1054/bjoc.2001.2100 · Cited by 301
Metadata
- Authors
- Hallahan, D. E., Spriggs, D. R., Beckett, M. A., Kufe, D. W., & Weichselbaum, R. R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-12
- Volume
- 86
- Issue
- 24
- Pages
- 10104-10107
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2023246619
- Cited by
- 464
- References
- 1
- FWCI
- 11.43
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. https://app.cochat.ai/papers/10.1073/pnas.86.24.10104
- The paper
- Hallahan, D. E., Spriggs, D. R., Beckett, M. A., Kufe, D. W., & Weichselbaum, R. R. (1989). Increased tumor necrosis factor alpha mRNA after cellular exposure to ionizing radiation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.24.10104
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
