Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.

Mauch, Peter; Constine, Louis; Greenberger, Joel; Knospe, William; Sullivan, Jessie; Liesveld, Jane L.; Deeg, H.Joachim

doi:10.1016/0360-3016(94)00430-s

Cited by 507Hematopoietic Stem Cell TransplantationEffects of Radiation ExposureReproductive Biology and Fertility

Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.

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Mauch, Peter, Constine, Louis, Greenberger, Joel, Knospe, William, Sullivan, Jessie, Liesveld, Jane L., Deeg, H.Joachim·1995·International Journal of Radiation Oncology*Biology*Physics

DOI 10.1016/0360-3016(94)00430-s

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Abstract

The bone marrow is an important dose-limiting cell renewal tissue for chemotherapy, wide-field irradiation, and autologous bone marrow transplantation. Over the past 5-10 years a great deal has been discovered about the hematopoietic stem cell compartment. Although the toxicity associated with prolonged myelosuppression continues to limit the wider use of chemotherapy and irradiation, ways are being discovered to circumvent this toxicity such as with the increasing use of cytokines. This review describes what is known of how chemotherapy and irradiation damage stem cells and the microenvironment, how cytokines protect hematopoietic cells from radiation damage and speed marrow recovery after chemotherapy or marrow transplantation, and how various types of blood marrow cells contribute to engraftment and long-term hematopoiesis after high doses of cytotoxic agents and/or total body irradiation.

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BM suppression is one of the common side effects of radiotherapy and the primary cause of death after exposure to a moderate or high dose of TBI.
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Long-term cancer survivors are at increased risk for developing late effects related to cancer treatment, including IR-induced residual BM injury.
“long-term cancer survivors are at increased risk for developing late effects related to cancer treatment, including IR-induced residual BM injury”
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IR-induced residual BM injury can deteriorate to become hypoplastic anemia or myelodysplastic syndrome over time or after additional treatment with IR and/or chemotherapy or undergoing autologous BM transplantation.
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From Total body irradiation causes long-term mouse BM injury via induction of HSC premature senescence in an Ink4a- and Arf-independent manner (2014) · cites this paper as [1]

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Authors: Mauch, P., Constine, L., Greenberger, J., Knospe, W., Sullivan, J., Liesveld, J. L., & Deeg, H. J.
Affiliations: Harvard University (US)
University of Rochester Medicine (US)
University of Pittsburgh Medical Center (US)
New York University (US)
University of Washington (US)
Corresponding author: Mauch, Peter
ORCID: Mauch, Peter
Constine, Louis
Greenberger, Joel
Liesveld, Jane L.
Deeg, H.Joachim
Venue: International Journal of Radiation Oncology*Biology*Physics
Publisher: Elsevier BV
Published: 1995-03
Volume: 31
Issue: 5
Pages: 1319-1339
ISSN: 0360-3016 (ISSN-L)
DOI: 10.1016/0360-3016(94)00430-s
OpenAlex: W2082603775
Cited by: 507
References: 172
Citations by year: 2026: 13 · 2025: 24 · 2024: 24 · 2023: 26 · 2022: 24 · 2021: 22 · 2020: 33 · 2019: 21 · 2018: 25 · 2017: 28 · 2016: 28 · 2015: 33 · 2014: 23 · 2013: 19 · 2012: 25
FWCI: 2.54
Type: journal article
Language: en
Open access: hybrid
doi.org
Licence: cc-by-nc-nd
www.elsevier.com/tdm/userlicense/1.0/ (tdm)
www.elsevier.com/legal/tdmrep-license (tdm)
creativecommons.org/licenses/by-nc-nd/4.0/ (vor, 1814 d)
Locations: International Journal of Radiation Oncology*Biology*Physics (publishedVersion, cc-by-nc-nd)
PubMed (publishedVersion)
Topics: Health Sciences › Medicine › Hematology › Hematopoietic Stem Cell Transplantation
Health Sciences › Medicine › Radiology, Nuclear Medicine and Imaging › Effects of Radiation Exposure
Health Sciences › Medicine › Public Health, Environmental and Occupational Health › Reproductive Biology and Fertility
Keywords: hematopoietic stem cells, radiotherapy, chemotherapy, myelosuppression, bone marrow microenvironment, cytokines, autologous bone marrow transplantation, total body irradiation, engraftment, hematopoiesis
MeSH terms: Animals, Bone Marrow Diseases, Dogs, Hematopoietic Stem Cells, Humans, Radiation Dosage, Radiation Tolerance, Radiotherapy, Whole-Body Irradiation, Bone Marrow Transplantation, Hematopoietic Cell Growth Factors, Mice

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Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.

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