The DOI matches its Crossref record.
Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure.
Open accessAbstract
We report here a five-step purification procedure that led to the isolation from fetal calf bone marrow extract of a tetrapeptide, Ac-Ser-Asp-Lys-Pro (Mr 487), exerting a high inhibitory activity on the proliferation of hematopoietic pluripotent stem cells [defined here as spleen colony-forming units (CFU-S)]. The structure of this molecule was established from amino acid analysis, fast atom bombardment mass spectrometry, and 1H nuclear magnetic resonance spectral data. This structure was confirmed by comparison with the corresponding synthetic molecule, which presents identical physiochemical characteristics and biological properties. Natural and synthetic peptides administered to mice (at a dose of 100 ng per mouse) after one injection of cytosine arabinonucleoside prevent CFU-S recruitment into DNA synthesis.
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Citations
Cited by
Hematopoietic stem cell compartment: acute and late effects of radiation therapy and chemotherapy.
Mauch, P., Constine, L., Greenberger, J., Knospe, W., Sullivan, J., Liesveld, J. L., & Deeg, H. J. (1995) · International Journal of Radiation Oncology*Biology*Physics · doi:10.1016/0360-3016(94)00430-s · Cited by 507
Stem cells: the generation and maintenance of cellular diversity
Hall, P. A., & Watt, F. M. (1989) · Development · doi:10.1242/dev.106.4.619 · Cited by 506
β-Thymosins, small acidic peptides with multiple functions
Huff, T., Müller, C. S. G., Otto, A. M., Netzker, R., & Hannappel, E. (2001) · The International Journal of Biochemistry & Cell Biology · doi:10.1016/s1357-2725(00)00087-x · Cited by 377
Bernstein, K. E., Ong, F. S., Blackwell, W.-L. B., Shah, K. H., Giani, J. F., Gonzalez-Villalobos, R. A., Shen, X. Z., & Fuchs, S. (2013) · Pharmacological Reviews · doi:10.1124/pr.112.006809 · Cited by 324
Cavasin, M. A. (2006) · American Journal of Cardiovascular Drugs · doi:10.2165/00129784-200606050-00003 · Cited by 46
Metadata
- Authors
- Lenfant, M., Wdzieczak-Bakala, J., Guittet, E., Prome, J. C., Sotty, D., & Frindel, E.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-02
- Volume
- 86
- Issue
- 3
- Pages
- 779-782
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2077135521
- Cited by
- 238
- References
- 0
- FWCI
- 9.66
- Type
- journal article
- Language
- en
- Open access
- green
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- Lenfant, M., Wdzieczak-Bakala, J., Guittet, E., Prome, J. C., Sotty, D., & Frindel, E. (1989). Inhibitor of hematopoietic pluripotent stem cell proliferation: purification and determination of its structure. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.3.779
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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