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Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP.
Open accessAbstract
The actions of somatostatin and of the phorbol ester 4 beta-phorbol 12-myristate 13-acetate (PMA) were studied in rat insulinoma (RINm5F) cells by electrophysiological and 86Rb+ flux techniques. Both PMA and somatostatin hyperpolarize insulinoma cells by activating ATP-sensitive K+ channels. The presence of intracellular GTP is required for the somatostatin effects. PMA- and somatostatin-induced hyperpolarization and channel activity are inhibited by the sulfonylurea glibenclamide. Glibenclamide-sensitive 86Rb+ efflux from insulinoma cells is stimulated by somatostatin in a dose-dependent manner (half maximal effect at 0.7 nM) and abolished by pertussis toxin pretreatment. Mutual roles of a GTP-binding protein, of protein kinase C, and of cAMP in the regulation of ATP-sensitive K+ channels are discussed.
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Citations
Cites
Tsunoo, A., Yoshii, M., & Narahashi, T. (1986) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.83.24.9832 · Cited by 218
Cited by
Somatostatin and Its Receptor Family
Patel, Y. C. (1999) · Frontiers in Neuroendocrinology · doi:10.1006/frne.1999.0183 · Cited by 1,648
Molecular Biology of Adenosine Triphosphate-Sensitive Potassium Channels*
Aguilar-Bryan, L., & Bryan, J. (1999) · Endocrine Reviews · doi:10.1210/edrv.20.2.0361 · Cited by 698
Heurteaux, C., Lauritzen, I., Widmann, C., & Lazdunski, M. (1995) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.92.10.4666 · Cited by 553
Self-citationRegulation and function of somatostatin receptors
Olias, G., Viollet, C., Kusserow, H., Epelbaum, J., & Meyerhof, W. (2004) · Journal of Neurochemistry · doi:10.1111/j.1471-4159.2004.02402.x · Cited by 318
Hyperinsulinism in Infancy: From Basic Science to Clinical Disease
DUNNE, M. J., COSGROVE, K. E., SHEPHERD, R. M., AYNSLEY-GREEN, A., & LINDLEY, K. J. (2004) · Physiological Reviews · doi:10.1152/physrev.00022.2003 · Cited by 294
Metadata
- Authors
- de Weille, J. R., Schmid-Antomarchi, H., Fosset, M., & Lazdunski, M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-04
- Volume
- 86
- Issue
- 8
- Pages
- 2971-2975
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2091205538
- Cited by
- 164
- References
- 1
- FWCI
- 5.08
- Type
- journal article
- Language
- en
- Open access
- bronze
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- CoChat. (2026). Citation check: Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP. https://app.cochat.ai/papers/10.1073/pnas.86.8.2971
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- de Weille, J. R., Schmid-Antomarchi, H., Fosset, M., & Lazdunski, M. (1989). Regulation of ATP-sensitive K+ channels in insulinoma cells: activation by somatostatin and protein kinase C and the role of cAMP. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.8.2971
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
