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Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes.
Open accessAbstract
The cDNAs for two putative glucose transporters from mouse 3T3-L1 adipocytes were isolated and sequenced. One of these cDNAs encodes the murine homolog of the human hepG2/erythrocyte glucose transporter, termed GT1. GT1 mRNA is most abundant in mouse brain and is expressed in both 3T3-L1 preadipocytes and adipocytes. The other cDNA encodes a glucose transporter-like protein, termed GT2, that has a unique amino acid sequence and tissue distribution. GT2 cDNA encodes a protein with 63% amino acid sequence identity and a similar structural organization to GT1. GT2 mRNA is found at high levels in mouse skeletal muscle, heart, and adipose tissue, all of which exhibit insulin-stimulated glucose uptake. GT2 mRNA is absent from 3T3-L1 preadipocytes but is induced dramatically during differentiation into adipocytes. This increase in mRNA content correlates closely with the acquisition of insulin-stimulated glucose uptake. We propose that GT2 is an insulin-regulated glucose transporter.
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Citations
Cited by
The glucose transporter family: structure, function and tissue-specific expression
Gould, G. W., & Holman, G. D. (1993) · Biochemical Journal · doi:10.1042/bj2950329 · Cited by 785
Stephens, J. M., Lee, J., & Pilch, P. F. (1997) · Journal of Biological Chemistry · doi:10.1074/jbc.272.2.971 · Cited by 553
Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 522
Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family
Olson, A. L., & Pessin, J. E. (1996) · Annual Review of Nutrition · doi:10.1146/annurev.nu.16.070196.001315 · Cited by 455
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes
Watson, R. T., Kanzaki, M., & Pessin, J. E. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0011 · Cited by 448
Metadata
- Authors
- Kaestner, K. H., Christy, R. J., McLenithan, J. C., Braiterman, L. T., Cornelius, P., Pekala, P. H., & Lane, M. D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-05
- Volume
- 86
- Issue
- 9
- Pages
- 3150-3154
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2072850070
- Cited by
- 305
- References
- 0
- FWCI
- 13.76
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. https://app.cochat.ai/papers/10.1073/pnas.86.9.3150
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- Kaestner, K. H., Christy, R. J., McLenithan, J. C., Braiterman, L. T., Cornelius, P., Pekala, P. H., & Lane, M. D. (1989). Sequence, tissue distribution, and differential expression of mRNA for a putative insulin-responsive glucose transporter in mouse 3T3-L1 adipocytes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.9.3150
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