The DOI matches its Crossref record; 73 of the 73 references it cites were found in a registry or an index.
Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family
Abstract
The facilitative transport of glucose across the plasma membranes of mammalian cells is catalyzed by a family of glucose transport proteins (GLUT). Four glucose transport proteins and a fructose transport protein have been identified. These transport proteins have unique tissue distributions and biochemical properties under- lying specific physiologic functions. GLUT1, the first GLUT isoform identified, is expressed at highest levels in the endothelial of barrier tissues such as blood vessels and the blood-brain barrier. GLUT2, found predominantly in liver, intestine, kidney, and pancreatic beta-cells, is a low-affinity glucose transport protein that is part of the glucose sensor in pancreatic beta-cells and facilitates either glucose uptake or efflux from the liver depending on the nutritional state. GLUT3 is the glucose transporter responsible for maintaining an adequate glucose supply to neurons. GLUT4 is the insulin-regulated glucose transporter found in adipose tissues, heart muscles, and skeletal muscles that is responsible for insulin-regulated glucose disposal.
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Cites
Facilitative glucose transporters
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Molecular Biology of Mammalian Glucose Transporters
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Insulin-regulatable tissues express a unique insulin-sensitive glucose transport protein
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Shepherd, P. R., Gnudi, L., Tozzo, E., Yang, H., Leach, F., & Kahn, B. B. (1993) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(18)41516-5 · Cited by 522
Glucose transporter proteins in brain
Maher, F., Vannucci, S. J., & Simpson, I. A. (1994) · The FASEB Journal · doi:10.1096/fasebj.8.13.7926364 · Cited by 511
Simpson, I. A., Chundu, K. R., Davies‐Hill, T., Honer, W. G., & Davies, P. (1994) · Annals of Neurology · doi:10.1002/ana.410350507 · Cited by 490
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Cardiac and adipose tissue abnormalities but not diabetes in mice deficient in GLUT4
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Kayano, T., Fukumoto, H., Eddy, R. L., Fan, Y. S., Byers, M. G., Shows, T. B., & Bell, G. I. (1988) · Journal of Biological Chemistry · doi:10.1016/s0021-9258(19)37577-5 · Cited by 430
Cited by
Pao, S. S., Paulsen, I. T., & Saier, M. H. (1998) · Microbiology and Molecular Biology Reviews · doi:10.1128/mmbr.62.1.1-34.1998 · Cited by 2,297
Homeostasis, Inflammation, and Disease Susceptibility
Kotas, M. E., & Medzhitov, R. (2015) · Cell · doi:10.1016/j.cell.2015.02.010 · Cited by 1,213
Glucose transporters in adipose tissue, liver, and skeletal muscle in metabolic health and disease
Chadt, A., & Al-Hasani, H. (2020) · Pflügers Archiv - European Journal of Physiology · doi:10.1007/s00424-020-02417-x · Cited by 510
Regulated Membrane Trafficking of the Insulin-Responsive Glucose Transporter 4 in Adipocytes
Watson, R. T., Kanzaki, M., & Pessin, J. E. (2004) · Endocrine Reviews · doi:10.1210/er.2003-0011 · Cited by 448
Self-citationRegulation of Amino Acid and Glucose Transporters in Endothelial and Smooth Muscle Cells
Mann, G. E., Yudilevich, D. L., & Sobrevia, L. (2003) · Physiological Reviews · doi:10.1152/physrev.00022.2002 · Cited by 430
Metadata
- Authors
- Olson, A. L., & Pessin, J. E.
- Venue
- Annual Review of Nutrition
- Publisher
- Annual Reviews
- Published
- 1996-07
- Volume
- 16
- Issue
- 1
- Pages
- 235-256
- ISSN
- 0199-9885 (ISSN-L)
- 1545-4312
- OpenAlex
- W2119744230
- Cited by
- 455
- References
- 73
- FWCI
- 4.82
- Type
- journal article
- Language
- en
- Open access
- closed
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- CoChat. (2026). Citation check: Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family. https://app.cochat.ai/papers/10.1146/annurev.nu.16.070196.001315
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- Olson, A. L., & Pessin, J. E. (1996). Structure, Function, and Regulation of the Mammalian Facilitative Glucose Transporter Gene Family. Annual Review of Nutrition. https://doi.org/10.1146/annurev.nu.16.070196.001315
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
