The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.
Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis.
Open accessAbstract
We have previously experimentally analyzed the structural requirements for interaction between peptide antigens and mouse major histocompatibility complex (MHC) molecules of the d haplotype. We describe here two procedures devised to predict specifically the capacity of peptide molecules to interact with these MHC class II molecules (IAd and IEd). The accuracy of these procedures has been tested on a large panel of synthetic peptides of eukaryotic, prokaryotic, and viral origin, and also on a set of overlapping peptides encompassing the entire staphylococcal nuclease molecule. For both sets of peptides, IAd and IEd binding was successfully predicted in approximately 75% of the cases. This suggests that definition of such sequence "motifs" could be of general use in predicting potentially immunogenic peptide regions within proteins.
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Cites
Atlas of protein sequence and structure
Chang, M.-Y., Dayhoff, M. O., Eck, R. V., & Sochard, M. R. (1965) · NASA Technical Reports Server (NASA) · Cited by 4,383
Statistical Methods in Biology
Bailey, N. T. J. (1960) · The Medical Journal of Australia · doi:10.5694/j.1326-5377.1960.tb62728.x · Cited by 861
A sequence pattern common to T cell epitopes.
Rothbard, J. B., & Taylor, W. R. (1988) · The EMBO Journal · doi:10.1002/j.1460-2075.1988.tb02787.x · Cited by 601
T-cell antigenic sites tend to be amphipathic structures.
DeLisi, C., & Berzofsky, J. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.20.7048 · Cited by 515
Prediction of immunodominant helper T cell antigenic sites from the primary sequence.
Margalit, H., Spouge, J. L., Cornette, J. L., Cease, K. B., Delisi, C., & Berzofsky, J. A. (1987) · The Journal of Immunology · doi:10.4049/jimmunol.138.7.2213 · Cited by 474
Isolation and characterization of antigen-la complexes involved in T cell recognition
Buus, S., Sette, A., Colon, S. M., Jenis, D. M., & Grey, H. M. (1986) · Cell · doi:10.1016/0092-8674(86)90822-6 · Cited by 467
Self-citationSette, A., Buus, S., Colon, S., Smith, J. A., Miles, C., & Grey, H. M. (1987) · Nature · doi:10.1038/328395a0 · Cited by 364
Self-citationStatistical Methods in Biology.
Bailey, N. T. J. (1995) · Biometrics · doi:10.2307/2533361 · Cited by 287
Immunological Self, Nonself Discrimination
Guillet, J.-G., Lai, M.-Z., Briner, T. J., Buus, S., Sette, A., Grey, H. M., Smith, J. A., & Gefter, M. L. (1987) · Science · doi:10.1126/science.2433769 · Cited by 274
Self-citationInteraction of an immunodominant epitope with Ia molecules in T-cell activation.
Adorini, L., Sette, A., Buus, S., Grey, H. M., Darsley, M. J., Lehmann, P. V., Doria, G., Nagy, Z. Á., & Appella, E. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.14.5181 · Cited by 76
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Cited by
MHC ligands and peptide motifs: first listing
Rammensee, H.-G., Friede, T., & Stevanović, S. (1995) · Immunogenetics · doi:10.1007/bf00172063 · Cited by 1,638
Dominance and Crypticity of T Cell Antigenic Determinants
Sercarz, E. (1993) · Annual Review of Immunology · doi:10.1146/annurev.immunol.11.1.729 · Cited by 855
Buus, S., Lauemøller, S. L., Worning, P., Kesmir, C., Frimurer, T., Corbet, S., Fomsgaard, A., Hilden, J., Holm, A., & Brunak, S. (2003) · Tissue Antigens · doi:10.1034/j.1399-0039.2003.00112.x · Cited by 329
Self-citationSimonds, E. F., Lu, E. D., Badillo, O., Karimi, S., Liu, E. V., Tamaki, W., Rancan, C., Downey, K. M., Stultz, J., Sinha, M., et al. (2021) · Journal for ImmunoTherapy of Cancer · doi:10.1136/jitc-2020-002181 · Cited by 119
Zinsli, L. V., Stierlin, N., Loessner, M. J., & Schmelcher, M. (2021) · Computational and Structural Biotechnology Journal · doi:10.1016/j.csbj.2020.12.024 · Cited by 63
Metadata
- Authors
- Sette, A., Buus, S., Appella, E., Smith, J. A., Chesnut, R., Miles, C., Colon, S. M., & Grey, H. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1989-05
- Volume
- 86
- Issue
- 9
- Pages
- 3296-3300
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2035194338
- Cited by
- 310
- References
- 10
- FWCI
- 5.70
- Type
- journal article
- Language
- en
- Open access
- green
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- Sette, A., Buus, S., Appella, E., Smith, J. A., Chesnut, R., Miles, C., Colon, S. M., & Grey, H. M. (1989). Prediction of major histocompatibility complex binding regions of protein antigens by sequence pattern analysis. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.86.9.3296
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