The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Low density lipoprotein rich in oleic acid is protected against oxidative modification: implications for dietary prevention of atherosclerosis.
Open accessAbstract
Oxidative modification of low density lipoprotein (LDL) enhances its potential atherogenicity in several ways, notably by enhancing its uptake into macrophages. In vivo studies in the rabbit show that inhibition of LDL oxidation slows the progression of atherosclerotic lesions. In the present studies, rabbits were fed either a newly developed variant sunflower oil (Trisun 80), containing more than 80% oleic acid and only 8% linoleic acid, or conventional sunflower oil, containing only 20% oleic acid and 67% linoleic acid. LDL isolated from the plasma of animals fed the variant sunflower oil was highly enriched in oleic acid and very low in linoleic acid. These oleate-rich LDL particles were remarkably resistant to oxidative modification. Even after 16-hr exposure to copper-induced oxidation or 24-hr incubation with cultured endothelial cells, macrophage uptake of the LDL was only marginally enhanced. The results suggest that diets sufficiently enriched in oleic acid, in addition to their LDL-lowering effect, may slow the progression of atherosclerosis by generating LDL that is highly resistant to oxidative modification.
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THE DIET AND 15-YEAR DEATH RATE IN THE SEVEN COUNTRIES STUDY
KEYS, A., MIENOTTI, A., KARVONEN, M. J., ARAVANIS, C., BLACKBURN, H., BUZINA, R., DJORDJEVIC, B. S., DONTAS, A. S., FIDANZA, F., KEYS, M. H., et al. (1986) · American Journal of Epidemiology · doi:10.1093/oxfordjournals.aje.a114480 · Cited by 1,790
DAYTON, S., PEARCE, M. L., HASHIMOTO, S., DIXON, W. J., & TOMIYASU, U. (1969) · Circulation · doi:10.1161/01.cir.40.1s2.ii-1 · Cited by 595
Cited by
Simopoulos, A. P. (2006) · Biomedicine & Pharmacotherapy · doi:10.1016/j.biopha.2006.07.080 · Cited by 1,143
Types of Dietary Fat and Risk of Coronary Heart Disease: A Critical Review
Hu, F. B., Manson, J. E., & Willett, W. C. (2001) · Journal of the American College of Nutrition · doi:10.1080/07315724.2001.10719008 · Cited by 902
The Effect of Polyphenols in Olive Oil on Heart Disease Risk Factors: A Randomized Trial
Covas, M.-I., Nyyssönen, K., Poulsen, H. E., Kaikkonen, J., Zunft, H.-J. F., Kiesewetter, H., Gaddi, A., de la Torre, R., Mursu, J., Bäumler, H., et al. (2006) · Annals of Internal Medicine · doi:10.7326/0003-4819-145-5-200609050-00006 · Cited by 758
Plant-based foods and prevention of cardiovascular disease: an overview
Hu, F. B. (2003) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/78.3.544s · Cited by 700
Chalasani, N., Deeg, M. A., & Crabb, D. W. (2004) · The American Journal of Gastroenterology · doi:10.1111/j.1572-0241.2004.30159.x · Cited by 343
Metadata
- Authors
- Parthasarathy, S., Khoo, J. C., Miller, E., Barnett, J., Witztum, J. L., & Steinberg, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-05
- Volume
- 87
- Issue
- 10
- Pages
- 3894-3898
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1986053342
- Cited by
- 459
- References
- 2
- FWCI
- 37.86
- Type
- journal article
- Language
- en
- Open access
- green
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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