Systemic Levels of Lipid Peroxidation and Its Metabolic and Dietary Correlates in Patients with Nonalcoholic Steatohepatitis
Abstract
Background and aim Products of systemic lipid peroxidation are important in the pathogenesis of cardiovascular disease. Subjects with NASH have increased hepatic lipid peroxidation, but it is unknown if they have increased oxidative stress and lipid peroxidation systemically. Therefore, we conducted a study to measure the circulating levels of lipid peroxidation products and their metabolic and nutritional correlates in patients with NASH and controls. Methods Systemic lipid peroxidation was assessed by measuring the levels of oxidized LDL (ox-LDL) and thiobarbituric acid-reacting substances (TBARS) in 21 subjects with NASH and 19 controls. Correlations were made between serum lipid peroxidation and nutritional determinants of oxidative stress and defense, serum lipids, insulin resistance, transaminases, and liver histology. The short-term nutrient intake was analyzed by maintaining a 3-wk dietary diary. Results The serum levels of ox-LDL were significantly higher in NASH patients compared to controls (56 +/- 16 U/L vs 40 +/- 12 U/L, respectively, p Conclusion Subjects with NASH have significantly higher systemic levels of lipid peroxidation products and this could indicate an increased risk of cardiovascular disease. More studies are needed to evaluate this possibility.
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Clinical studies have reported an increase in lipid peroxidation in patients with NASH.
“Clinical studies have also reported an increase in lipid peroxidation in patients with NASH [33].”
From Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells (2021) · cites this paper as [33]
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Adaptive immune responses triggered by oxidative stress contribute to hepatic inflammation in NASH
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Self-citationHow Inflammation Impinges on NAFLD: A Role for Kupffer Cells
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Intervention by picroside II on FFAs induced lipid accumulation and lipotoxicity in HepG2 cells
Dhami-Shah, H., Vaidya, R., Talwadekar, M., Shaw, E., Udipi, S., Kolthur-Seetharam, U., & Vaidya, A. D. B. (2021) · Journal of Ayurveda and Integrative Medicine · doi:10.1016/j.jaim.2021.04.007 · Cited by 15 · see citing works
“Delaying the progression of NAFL to NASH at an earlier stage with safe intervention via natural drug therapies would therefore be worth exploring. isciplinary Health Sciences and Technology and World Ayurveda Foundation.”
BackgroundInfluential
- Authors
- Chalasani, N., Deeg, M. A., & Crabb, D. W.
- Affiliations
- Indiana University School of Medicine (US)
- Corresponding author
- Chalasani, Naga
- Venue
- The American Journal of Gastroenterology
- Published
- 2004-08
- Volume
- 99
- Issue
- 8
- Pages
- 1497-1502
- ISSN
- 0002-9270 (ISSN-L)
- 1572-0241
- OpenAlex
- W2020242068
- Cited by
- 343
- References
- 1
- Citations by year
- 2026: 4 · 2025: 8 · 2024: 6 · 2023: 10 · 2022: 6 · 2021: 9 · 2020: 21 · 2019: 10 · 2018: 16 · 2017: 20 · 2016: 17 · 2015: 21 · 2014: 24 · 2013: 23 · 2012: 27
- FWCI
- 7.53
- Type
- journal article
- Language
- en
- Open access
- closed
- Locations
- The American Journal of Gastroenterology (publishedVersion)
- PubMed (publishedVersion)
- Funders
- National Institutes of Health
- School of Medicine, Indiana University
- National Institute on Alcohol Abuse and Alcoholism (P60 AA 07611, P60AA007611)
- National Institute of Diabetes and Digestive and Kidney Diseases (DK56012)
- National Center for Research Resources (RR 00750, M01RR000750)
- Topics
- Health Sciences › Medicine › Biochemistry › Antioxidant Activity and Oxidative Stress
- Health Sciences › Medicine › Epidemiology › Liver Disease Diagnosis and Treatment
- Life Sciences › Biochemistry, Genetics and Molecular Biology › Clinical Biochemistry › Paraoxonase enzyme and polymorphisms
- Keywords
- nonalcoholic steatohepatitis, lipid peroxidation, oxidized LDL, thiobarbituric acid-reacting substances, oxidative stress, insulin resistance, dietary intake, cardiovascular risk, serum lipids, liver histopathology
- MeSH terms
- Adult, Blood Glucose, Cardiovascular Diseases, Cholesterol, Diet, Fatty Liver, Female, Humans, Insulin, Lipoproteins, LDL, Cholesterol, LDL, Liver, Male, Risk Factors, Triglycerides, Lipid Peroxidation, Thiobarbituric Acid Reactive Substances, Oxidative Stress, Metabolic Syndrome
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