The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2.
Open accessAbstract
The human anti-oncoprotein p53 is shown to be a substrate of cdc2. The primary site of phosphorylation is serine-315. Serine-315 is phosphorylated by both p60-cdc2 and cyclin B-cdc2 enzymes. The phosphorylation of p53 is cell cycle-dependent. The abundance of p53 also oscillates during the cell cycle. The protein is largely absent from cells that have just completed division but accumulates in cells during G1 phase. Phosphorylation by cdc2 might regulate the antiproliferative activity of p53.
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Citations
Cites
The p53 proto-oncogene can act as a suppressor of transformation
Finlay, C. A., Hinds, P. W., & Levine, A. J. (1989) · Cell · doi:10.1016/0092-8674(89)90045-7 · Cited by 1,987
Whyte, P., Buchkovich, K. J., Horowitz, J. M., Friend, S. H., Raybuck, M., Weinberg, R. A., & Harlow, E. (1988) · Nature · doi:10.1038/334124a0 · Cited by 1,403
Cited by
Mice deficient for p53 are developmentally normal but susceptible to spontaneous tumours
Donehower, L. A., Harvey, M., Slagle, B. L., McArthur, M. J., Montgomery, C. A., Butel, J. S., & Bradley, A. (1992) · Nature · doi:10.1038/356215a0 · Cited by 4,649
Momand, J., Zambetti, G. P., Olson, D. C., George, D., & Levine, A. J. (1992) · Cell · doi:10.1016/0092-8674(92)90644-r · Cited by 3,113
Weinberg, R. A. (1991) · Science · doi:10.1126/science.1659741 · Cited by 1,756
The complexity of p53 modulation: emerging patterns from divergent signals
Giaccia, A. J., & Kastan, M. B. (1998) · Genes & Development · doi:10.1101/gad.12.19.2973 · Cited by 1,314
The Global Phosphorylation Landscape of SARS-CoV-2 Infection
Bouhaddou, M., Memon, D., Meyer, B., White, K. M., Rezelj, V. V., Correa Marrero, M., Polacco, B. J., Melnyk, J. E., Ulferts, S., Kaake, R. M., et al. (2020) · Cell · doi:10.1016/j.cell.2020.06.034 · Cited by 1,020
Metadata
- Authors
- Bischoff, J. R., Friedman, P. N., Marshak, D. R., Prives, C., & Beach, D.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-06
- Volume
- 87
- Issue
- 12
- Pages
- 4766-4770
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2078731043
- Cited by
- 342
- References
- 2
- FWCI
- 20.91
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. https://app.cochat.ai/papers/10.1073/pnas.87.12.4766
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- Bischoff, J. R., Friedman, P. N., Marshak, D. R., Prives, C., & Beach, D. (1990). Human p53 is phosphorylated by p60-cdc2 and cyclin B-cdc2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.12.4766
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