The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine.
Open accessAbstract
We show that the stimulation of human immunodeficiency virus (HIV) brought about by tumor necrosis factor alpha and phorbol 12-myristate 13-acetate can be inhibited by adding N-acetyl-L-cysteine (NAC). NAC, which replenishes intracellular glutathione, effectively inhibits the tumor necrosis factor alpha- or phorbol ester-stimulated replication of HIV in acutely infected cell cultures. NAC also inhibits the cytokine-enhanced HIV long terminal repeat-directed expression of beta-galactosidase in in vitro HIV model systems. These results show that intracellular thiol levels influence HIV production. Furthermore, because NAC reverses tumor necrosis factor alpha toxicity both in cells and in animals and is a well-known drug that can be administered orally without known toxicity in humans, these results suggest that NAC is a possible therapeutic agent in AIDS.
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Efficacy of Oral N-Acetylcysteine in the Treatment of Acetaminophen Overdose
Smilkstein, M. J., Knapp, G. L., Kulig, K. W., & Rumack, B. H. (1988) · New England Journal of Medicine · doi:10.1056/nejm198812153192401 · Cited by 1,102
Tat trans-activates the human immunodeficiency virus through a nascent RNA target
Berkhout, B., Silverman, R. H., & Jeang, K.-T. (1989) · Cell · doi:10.1016/0092-8674(89)90289-4 · Cited by 647
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Takei, H., Araki, A., Watanabe, H., Ichinose, A., & Sendo, F. (1996) · Journal of Leukocyte Biology · doi:10.1002/jlb.59.2.229 · Cited by 426
Glutathione Deficiency and Human Immunodeficiency Virus Infection
Staal, F. J. T., Ela, S. W., Roederer, M., Anderson, M. T., Herzenberg, L. A., & Herzenberg, L. A. (1992) · The Lancet · doi:10.1016/0140-6736(92)90939-z · Cited by 404
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Low levels of reactive oxygen species as modulators of cell function
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Metadata
- Authors
- Roederer, M., Staal, F. J., Raju, P. A., Ela, S. W., Herzenberg, L. A., & Herzenberg, L. A.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-06
- Volume
- 87
- Issue
- 12
- Pages
- 4884-4888
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2048158801
- Cited by
- 376
- References
- 2
- FWCI
- 6.57
- Type
- journal article
- Language
- en
- Open access
- green
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- Roederer, M., Staal, F. J., Raju, P. A., Ela, S. W., Herzenberg, L. A., & Herzenberg, L. A. (1990). Cytokine-stimulated human immunodeficiency virus replication is inhibited by N-acetyl-L-cysteine. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.12.4884
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