The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2.
Open accessAbstract
Entry into mitosis during the somatic cell cycle is regulated in response to signals that monitor the completion of DNA replication, the integrity of the nuclear genome, and, possibly, the increase in cellular mass during the cell cycle. It has been postulated that the operation of this cell cycle control involves the gradual accumulation of rate-limiting mitotic inducers, which trigger nuclear division when their cellular concentration reaches a critical level. We have cloned a human gene, which we call CDC25, whose product may function as a mitotic inducer. This human gene encodes a protein with a predicted molecular mass of 53,000 daltons whose C-terminal domain shares about 37% sequence identity with the fission yeast cdc25+ mitotic inducer. The human CDC25 gene rescues the defect of a fission yeast temperature-sensitive (ts) cdc25ts mutant that is unable to initiate mitosis. In HeLa cells CDC25 mRNA levels are very low in G1 and increase at least 4-fold as cells progress towards M phase. These data suggest that in human cells, as in fission yeast, the accumulation of CDC25 mitotic inducer during G2 may play a key role in regulating the timing of mitosis.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Primer-Directed Enzymatic Amplification of DNA with a Thermostable DNA Polymerase
Saiki, R. K., Gelfand, D. H., Stoffel, S., Scharf, S. J., Higuchi, R., Horn, G. T., Mullis, K. B., & Erlich, H. A. (1988) · Science · doi:10.1126/science.2448875 · Cited by 17,719
Cited by
Inactivation of the p34 cdc2 -Cyclin B Complex by the Human WEE1 Tyrosine Kinase
Parker, L. L., & Piwnica-Worms, H. (1992) · Science · doi:10.1126/science.1384126 · Cited by 716
Hoffmann, I., Clarke, P. R., Marcote, M. J., Karsenti, E., & Draetta, G. (1993) · The EMBO Journal · doi:10.1002/j.1460-2075.1993.tb05631.x · Cited by 684
The cdc25 protein contains an intrinsic phosphatase activity
Dunphy, W. G., & Kumagai, A. (1991) · Cell · doi:10.1016/0092-8674(91)90582-j · Cited by 586
Dephosphorylation and activation of a p34cdc2/cyclin B complex in vitro by human CDC25 protein
Strausfeld, U., Labbé, J. C., Fesquet, D., Cavadore, J. C., Picard, A., Sadhu, K., Russell, P., & Dorée, M. (1991) · Nature · doi:10.1038/351242a0 · Cited by 578
Self-citationThe cdc25 protein controls tyrosine dephosphorylation of the cdc2 protein in a cell-free system
Kumagai, A., & Dunphy, W. G. (1991) · Cell · doi:10.1016/0092-8674(91)90315-p · Cited by 503
Metadata
- Authors
- Sadhu, K., Reed, S. I., Richardson, H., & Russell, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-07
- Volume
- 87
- Issue
- 13
- Pages
- 5139-5143
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2060788204
- Cited by
- 350
- References
- 1
- FWCI
- 10.14
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. https://app.cochat.ai/papers/10.1073/pnas.87.13.5139
- The paper
- Sadhu, K., Reed, S. I., Richardson, H., & Russell, P. (1990). Human homolog of fission yeast cdc25 mitotic inducer is predominantly expressed in G2. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.13.5139
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
