The DOI matches its Crossref record; 36 of the 36 references it cites were found in a registry or an index.
Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma.
Open accessAbstract
Loss of heterozygosity on chromosome 16 is a common genetic alteration in human hepatocellular carcinoma (HCC). To clarify the pathogenetic significance of allele loss on chromosome 16, we performed restriction fragment length polymorphism analysis of 70 surgically resected tumors by using 15 polymorphic DNA markers for chromosome 16. Loss of heterozygosity on chromosome 16 was detected in 36 (52%) of 69 informative cases, and the common region of allele loss in these 36 tumors was located between the HP locus (16q22.1) and the CTRB locus (16q22.3-q23.2). These losses occurred more frequently in HCCs of poor differentiation, of larger size, and with metastasis, whereas they were not detected in HCC at the earliest stage. In addition, these losses were not associated with presence or absence of hepatitis B virus DNA integration or hepatitis C virus infection. These results show that loss of heterozygosity on chromosome 16 is a late event occurring after hepatocarcinogenesis and strongly suggest that this phenomenon is involved in enhancement of tumor aggressiveness during progression of HCC.
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Self-citationA human DNA segment with properties of the gene that predisposes to retinoblastoma and osteosarcoma
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Cited by
E-cadherin—catenin cell—cell adhesion complex and human cancer
Wijnhoven, B. P. L., Dinjens, W. N. M., & Pignatelli, M. (2000) · Journal of British Surgery · doi:10.1046/j.1365-2168.2000.01513.x · Cited by 451
Early Hepatocellular Carcinoma As An Entity With A High Rate of Surgical Cure
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Self-citationGenetics of hepatocellular carcinoma
Annick Buendia, M. (2000) · Seminars in Cancer Biology · doi:10.1006/scbi.2000.0319 · Cited by 329
Genetics of hepatocellular tumors
Laurent-Puig, P., & Zucman-Rossi, J. (2006) · Oncogene · doi:10.1038/sj.onc.1209547 · Cited by 317
E-cadherin gene mutations in human gastric carcinomacell lines.
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Metadata
- Authors
- Tsuda, H., Zhang, W. D., Shimosato, Y., Yokota, J., Terada, M., Sugimura, T., Miyamura, T., & Hirohashi, S.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-09
- Volume
- 87
- Issue
- 17
- Pages
- 6791-6794
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2069505491
- Cited by
- 289
- References
- 36
- FWCI
- 16.00
- Type
- journal article
- Language
- en
- Open access
- green
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- Tsuda, H., Zhang, W. D., Shimosato, Y., Yokota, J., Terada, M., Sugimura, T., Miyamura, T., & Hirohashi, S. (1990). Allele loss on chromosome 16 associated with progression of human hepatocellular carcinoma. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.17.6791
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