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Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase.
Open accessAbstract
Using a strategy based on nucleotide sequence homology between genes encoding receptors that interact with guanine nucleotide-binding proteins, we have isolated Drosophila genomic and cDNA clones encoding a functional serotonin receptor (5HT-dro receptor). This protein is expressed predominantly in Drosophila heads and exhibits highest homology with the human 5HT1A receptor. The predicted structure of the 5HT-dro receptor reveals two unusual features: (i) eight putative transmembrane domains instead of the expected seven and (ii) a Gly-Ser repeat that is a potential glycosaminoglycan attachment site. When stably introduced into mouse NIH 3T3 cells, the 5HT-dro receptor activates adenylate cyclase in response to serotonin and is inhibited by serotonin receptor antagonists such as dihydroergocryptine. The 5HT-dro receptor or closely related receptors might be responsible for the serotonin-sensitive cyclase that has been suggested to play a role in learning and modulation of circadian rhythm in a number of invertebrate systems.
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Cited by
Molecular biology of 5-HT receptors
Boess, F. G., & Martin, I. L. (1994) · Neuropharmacology · doi:10.1016/0028-3908(94)90059-0 · Cited by 677
Multiplicity of mechanisms of serotonin receptor signal transduction
Raymond, J. R., Mukhin, Y. V., Gelasco, A., Turner, J., Collinsworth, G., Gettys, T. W., Grewal, J. S., & Garnovskaya, M. N. (2001) · Pharmacology & Therapeutics · doi:10.1016/s0163-7258(01)00169-3 · Cited by 466
Biogenic amine systems in the fruit flyDrosophila melanogaster
Monastirioti, M. (1999) · Microscopy Research and Technique · doi:10.1002/(sici)1097-0029(19990415)45:2<106::aid-jemt5>3.0.co;2-3 · Cited by 260
Serotonergic modulation of walking in Drosophila
Howard, C. E., Chen, C.-L., Tabachnik, T., Hormigo, R., Ramdya, P., & Mann, R. S. (2019) · Current Biology · doi:10.1016/j.cub.2019.10.042 · Cited by 59
Kahsai, L., Carlsson, M. A., Winther, Å. M. E., & Nässel, D. R. (2012) · Neuroscience · doi:10.1016/j.neuroscience.2012.02.007 · Cited by 65
Metadata
- Authors
- Witz, P., Amlaiky, N., Plassat, J. L., Maroteaux, L., Borrelli, E., & Hen, R.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-11
- Volume
- 87
- Issue
- 22
- Pages
- 8940-8944
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2033067631
- Cited by
- 233
- References
- 0
- FWCI
- 4.05
- Type
- journal article
- Language
- en
- Open access
- green
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- Witz, P., Amlaiky, N., Plassat, J. L., Maroteaux, L., Borrelli, E., & Hen, R. (1990). Cloning and characterization of a Drosophila serotonin receptor that activates adenylate cyclase. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.22.8940
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