The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes.
Open accessAbstract
Antisera that recognize the alpha 6 and beta 4 subunits of integrins were found by immunoelectron microscopy to localize to hemidesmosomes in the basal cells of mouse corneal epithelium. Immunoprecipitation experiments using extracts of metabolically labeled corneal epithelial cells indicate that the primary alpha 6-subunit-containing integrin heterodimer present is alpha 6 beta 4 and not alpha 6 beta 1. Here we extend previous studies to report that by immunofluorescence microscopy the alpha 6 integrin subunit colocalizes with bullous pemphigoid antigen and type VII collagen in newly forming hemidesmosomes in the developing 17-day fetal rabbit eye. Neither the composition of the anchoring filaments, which span the region between the hemidesmosomal plaque and the lamina densa of basement membrane where the globular domain of type VII collagen is located, nor the extracellular ligand of alpha 6 beta 4 is known. Once anchoring filament proteins are identified, it will be of interest to determine whether any bind to alpha 6 beta 4.
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Peltonen, J., Larjava, H., Jaakkola, S., Gralnick, H., Akiyama, S. K., Yamada, S. S., Yamada, K. M., & Uitto, J. (1989) · Journal of Clinical Investigation · doi:10.1172/jci114379 · Cited by 220
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Integrins as receptors for laminins
Belkin, A. M., & Stepp, M. A. (2000) · Microscopy Research and Technique · doi:10.1002/1097-0029(20001101)51:3<280::aid-jemt7>3.0.co;2-o · Cited by 384
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Metadata
- Authors
- Stepp, M. A., Spurr-Michaud, S., Tisdale, A., Elwell, J., & Gipson, I. K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-11
- Volume
- 87
- Issue
- 22
- Pages
- 8970-8974
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2084628519
- Cited by
- 482
- References
- 1
- FWCI
- 9.12
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes. https://app.cochat.ai/papers/10.1073/pnas.87.22.8970
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- Stepp, M. A., Spurr-Michaud, S., Tisdale, A., Elwell, J., & Gipson, I. K. (1990). Alpha 6 beta 4 integrin heterodimer is a component of hemidesmosomes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.22.8970
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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