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Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line.
Open accessAbstract
During normal embryogenesis and neoplastic transformation epithelia change their state of differentiation and degree of cohesiveness. It is thus essential to identify the signals modulating these transitions. We report here that acidic fibroblast growth factor (FGF) induces cells derived from a rat bladder carcinoma to lose their epithelial character and to acquire some properties typical of mesenchymal cells. The structurally related basic FGF did not have such an effect; both factors, however, had a mitogenic activity for these cells. Two distinct populations of receptors for acidic FGF and basic FGF were distinguished by their ligand-binding characteristics. The observations that both acidic and basic FGFs had a mitogenic effect on NBT-II cells and that only acidic FGF caused cell dissociation and dispersion strongly suggest that these two biological activities could be medicated through distinct signaling pathways.
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Cited by
Guidelines and definitions for research on epithelial-mesenchymal transition
Yang, J., Antin, P., Berx, G., Blanpain, C., Brabletz, T., Bronner, M., Campbell, K., Cano, A., Casanova, J., Christofori, G., et al. (2020) · Nature Reviews Molecular Cell Biology · doi:10.1038/s41580-020-0237-9 · Cited by 2,226
Self-citationRegulation of development and differentiation by the extracellular matrix
Adams, J. C., & Watt, F. M. (1993) · Development · doi:10.1242/dev.117.4.1183 · Cited by 1,208
The epigenetics of epithelial-mesenchymal plasticity in cancer
Tam, W. L., & Weinberg, R. A. (2013) · Nature Medicine · doi:10.1038/nm.3336 · Cited by 1,163
TGF-β1 Signaling and Tissue Fibrosis
Kim, K. K., Sheppard, D., & Chapman, H. A. (2018) · Cold Spring Harbor Perspectives in Biology · doi:10.1101/cshperspect.a022293 · Cited by 800
Ji, H., Wang, J., Nika, H., Hawke, D., Keezer, S., Ge, Q., Fang, B., Fang, X., Fang, D., Litchfield, D. W., et al. (2009) · Molecular Cell · doi:10.1016/j.molcel.2009.09.034 · Cited by 270
Metadata
- Authors
- Vallés, A. M., Boyer, B., Badet, J., Tucker, G. C., Barritault, D., & Thiery, J. P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-02
- Volume
- 87
- Issue
- 3
- Pages
- 1124-1128
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2039161118
- Cited by
- 207
- References
- 0
- FWCI
- 6.89
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line. https://app.cochat.ai/papers/10.1073/pnas.87.3.1124
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- Vallés, A. M., Boyer, B., Badet, J., Tucker, G. C., Barritault, D., & Thiery, J. P. (1990). Acidic fibroblast growth factor is a modulator of epithelial plasticity in a rat bladder carcinoma cell line. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.3.1124
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