The DOI matches its Crossref record; 1 of the 1 references it cites were found in a registry or an index.
Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.
Open accessAbstract
We report on the production of tumor necrosis factor (TNF)-alpha and TNF-beta by mitogen-activated peripheral blood lymphocytes or enriched monocyte subpopulations from human leukocyte antigen (HLA)-typed healthy subjects. The results indicate that HLA-DR2- and DQw1-positive donors frequently exhibit low production of TNF-alpha, whereas DR3- and DR4-positive subjects show high levels of TNF-alpha production. No correlation between TNF-alpha levels and HLA-A, -B, and -C genotype was found. The relevance of this quantitative polymorphism to the genetic predisposition to lupus nephritis in systemic lupus erythematosus (SLE) patients was investigated. DR2, DQw1-positive SLE patients show low levels of TNF-alpha inducibility; this genotype is also associated with an increased incidence of lupus nephritis. DR3-positive SLE patients, on the other hand, are not predisposed to nephritis, and these patients have high TNF-alpha production. DR4 haplotype is associated with high TNF-alpha inducibility and is negatively correlated with lupus nephritis. These data may help explain the strong association between HLA-DR2, DQw1 in SLE patients and their susceptibility to nephritis.
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An endotoxin-induced serum factor that causes necrosis of tumors
Carswell, E. A., Old, L. J., Kassel, R. L., Green, S., Fiore, N., & Williamson, B. (1975) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.72.9.3666 · Cited by 4,532
Cited by
Messer, G., Spengler, U., Jung, M. C., Honold, G., Blömer, K., Pape, G. R., Riethmüller, G., & Weiss, E. H. (1991) · The Journal of experimental medicine · doi:10.1084/jem.173.1.209 · Cited by 543
Ishida, H., Muchamuel, T., Sakaguchi, S., Andrade, S., Menon, S., & Howard, M. (1994) · The Journal of experimental medicine · doi:10.1084/jem.179.1.305 · Cited by 532
A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies
Calder, P. C., Ahluwalia, N., Albers, R., Bosco, N., Bourdet-Sicard, R., Haller, D., Holgate, S. T., Jönsson, L. S., Latulippe, M. E., Marcos, A., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114512005119 · Cited by 425
BOUMA, G., CRUSIUS, J. B. A., OUDKERK POOL, M., KOLKMAN, J. J., VON BLOMBERG, B. M. E., KOSTENSE, P. J., GIPHART, M. J., SCHREUDER, G. M. T., MEUWISSEN, S. G. M., & PEÑA, A. S. (1996) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1996.d01-65.x · Cited by 373
Exotoxins and endotoxins: Inducers of inflammatory cytokines
Cavaillon, J.-M. (2018) · Toxicon · doi:10.1016/j.toxicon.2017.10.016 · Cited by 346
Metadata
- Authors
- Jacob, C. O., Fronek, Z., Lewis, G. D., Koo, M., Hansen, J. A., & McDevitt, H. O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-02
- Volume
- 87
- Issue
- 3
- Pages
- 1233-1237
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2028156913
- Cited by
- 627
- References
- 1
- FWCI
- 25.68
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. https://app.cochat.ai/papers/10.1073/pnas.87.3.1233
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- Jacob, C. O., Fronek, Z., Lewis, G. D., Koo, M., Hansen, J. A., & McDevitt, H. O. (1990). Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.3.1233
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