A Consideration of Biomarkers to be Used for Evaluation of Inflammation in Human Nutritional Studies

Atherosclerosis--an inflammatory disease

Ross, R. (1999) · New England Journal of Medicine · doi:10.1056/nejm199901143400207 · Cited by 21,725 · see citing works

MicroRNAs: Target Recognition and Regulatory Functions

Bartel, D. P. (2009) · Cell · doi:10.1016/j.cell.2009.01.002 · Cited by 20,068 · see citing works

An obesity-associated gut microbiome with increased capacity for energy harvest

Turnbaugh, P. J., Ley, R. E., Mahowald, M. A., Magrini, V., Mardis, E. R., & Gordon, J. I. (2006) · Nature · doi:10.1038/nature05414 · Cited by 12,444 · see citing works

Obesity is associated with macrophage accumulation in adipose tissue

Weisberg, S. P., McCann, D., Desai, M., Rosenbaum, M., Leibel, R. L., & Ferrante, A. W. (2003) · Journal of Clinical Investigation · doi:10.1172/jci200319246 · Cited by 10,041 · see citing works

Human gut microbes associated with obesity

Ley, R. E., Turnbaugh, P. J., Klein, S., & Gordon, J. I. (2006) · Nature · doi:10.1038/4441022a · Cited by 8,785 · see citing works

Inflammation, Atherosclerosis, and Coronary Artery Disease

Hansson, G. K. (2005) · New England Journal of Medicine · doi:10.1056/nejmra043430 · Cited by 8,773 · see citing works

Biomarkers and surrogate endpoints: Preferred definitions and conceptual framework

Biomarkers Definitions Working Group (2001) · Clinical Pharmacology & Therapeutics · doi:10.1067/mcp.2001.113989 · Cited by 6,771 · see citing works

Paradoxical Decrease of an Adipose-Specific Protein, Adiponectin, in Obesity

Arita, Y., Kihara, S., Ouchi, N., Takahashi, M., Maeda, K., Miyagawa, J.-I., Hotta, K., Shimomura, I., Nakamura, T., Miyaoka, K., et al. (1999) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.1999.0255 · Cited by 4,856 · see citing works

Changes in gut microbiota control metabolic endotoxemia-induced inflammation in high-fat diet-induced obesity and diabetes in mice

Cani, P. D., Bibiloni, R., Knauf, C., Waget, A., Neyrinck, A. M., Delzenne, N. M., & Burcelin, R. (2008) · Diabetes · doi:10.2337/db07-1403 · Cited by 4,819 · see citing works

<i>Faecalibacterium prausnitzii</i> is an anti-inflammatory commensal bacterium identified by gut microbiota analysis of Crohn disease patients

Sokol, H., Pigneur, B., Watterlot, L., Lakhdari, O., Bermúdez-Humarán, L. G., Gratadoux, J.-J., Blugeon, S., Bridonneau, C., Furet, J.-P., Corthier, G., et al. (2008) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.0804812105 · Cited by 4,413 · see citing works

Atherosclerosis

Glass, C. K., & Witztum, J. L. (2001) · Cell · doi:10.1016/s0092-8674(01)00238-0 · Cited by 3,049 · see citing works

THE MAMMALIAN UNFOLDED PROTEIN RESPONSE

Schröder, M., & Kaufman, R. J. (2005) · Annual Review of Biochemistry · doi:10.1146/annurev.biochem.73.011303.074134 · Cited by 3,035 · see citing works

MicroRNAs are transported in plasma and delivered to recipient cells by high-density lipoproteins

Vickers, K. C., Palmisano, B. T., Shoucri, B. M., Shamburek, R. D., & Remaley, A. T. (2011) · Nature Cell Biology · doi:10.1038/ncb2210 · Cited by 2,741 · see citing works

How should we define health?

Huber, M., Knottnerus, J. A., Green, L., van der Horst, H. E., Jadad, A. R., Kromhout, D., Leonard, B. E., Lorig, K. R., Loureiro, I., Meer, J. W. M. V. D., et al. (2011) · BMJ · doi:10.1136/bmj.d4163 · Cited by 2,644 · see citing works

Resolution of inflammation: the beginning programs the end

Serhan, C. N., & Savill, J. (2005) · Nature Immunology · doi:10.1038/ni1276 · Cited by 2,552 · see citing works

Elevated C-reactive protein levels in overweight and obese adults

Visser, M. (1999) · JAMA · doi:10.1001/jama.282.22.2131 · Cited by 2,494 · see citing works

C-Reactive Protein in Healthy Subjects: Associations With Obesity, Insulin Resistance, and Endothelial Dysfunction: A Potential Role for Cytokines Originating From Adipose Tissue?

Yudkin, J. S., Stehouwer, C. D. A., Emeis, J. J., & Coppack, S. W. (1999) · Arteriosclerosis, Thrombosis, and Vascular Biology · doi:10.1161/01.atv.19.4.972 · Cited by 2,465 · see citing works

The effect of novel polymorphisms in the interleukin-6 (IL-6) gene on IL-6 transcription and plasma IL-6 levels, and an association with systemic-onset juvenile chronic arthritis.

Fishman, D., Faulds, G., Jeffery, R., Mohamed-Ali, V, Yudkin, J. S., Humphries, S., & Woo, P. (1998) · Journal of Clinical Investigation · doi:10.1172/jci2629 · Cited by 2,243 · see citing works

Inflammatory Cytokine Concentrations Are Acutely Increased by Hyperglycemia in Humans: Role of Oxidative Stress

Esposito, K., Nappo, F., Marfella, R., Giugliano, G., Giugliano, F., Ciotola, M., Quagliaro, L., Ceriello, A., & Giugliano, D. (2002) · Circulation · doi:10.1161/01.cir.0000034509.14906.ae · Cited by 1,961 · see citing works

Disordered Microbial Communities in Asthmatic Airways

Hilty, M., Burke, C. M., Pedro, H., Cárdenas, P., Bush, A., Bossley, C. J., Davies, J. C., Ervine, A., Poulter, L. W., Pachter, L. S., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0008578 · Cited by 1,825 · see citing works

Exercise and the immune system: regulation, integration, and adaptation

Pedersen, B. K., & Hoffman-Goetz, L. (2000) · Physiological Reviews · doi:10.1152/physrev.2000.80.3.1055 · Cited by 1,710 · see citing works

Definition and diagnosis of diabetes mellitus and intermediate hyperglycemia. Report of a WHO/IDF Consultation

Unwin, N. C. (2006) · Cited by 1,661 · see citing works

Dominant and diet-responsive groups of bacteria within the human colonic microbiota

Walker, A. W., Ince, J., Duncan, S. H., Webster, L. M., Holtrop, G., Ze, X., Brown, D., Stares, M. D., Scott, P., Bergerat, A., et al. (2011) · The ISME Journal · doi:10.1038/ismej.2010.118 · Cited by 1,632 · see citing works

Role of interleukin 10 transcriptional regulation in inflammation and autoimmune disease.

Iyer, S. S., & Cheng, G. (2012) · Critical Reviews™ in Immunology · doi:10.1615/critrevimmunol.v32.i1.30 · Cited by 1,611 · see citing works

Effect of Weight Loss and Lifestyle Changes on Vascular Inflammatory Markers in Obese Women: A Randomized Trial

Esposito, K., Pontillo, A., Di Palo, C., Giugliano, G., Masella, M., Marfella, R., & Giugliano, D. (2003) · JAMA · doi:10.1001/jama.289.14.1799 · Cited by 1,511 · see citing works

Through Ageing, and Beyond: Gut Microbiota and Inflammatory Status in Seniors and Centenarians

Biagi, E., Nylund, L., Candela, M., Ostan, R., Bucci, L., Pini, E., Nikkïla, J., Monti, D., Satokari, R., Franceschi, C., et al. (2010) · PLoS ONE · doi:10.1371/journal.pone.0010667 · Cited by 1,483 · see citing works

MicroRNAs in body fluids—the mix of hormones and biomarkers

Cortez, M. A., Bueso-Ramos, C., Ferdin, J., Lopez‐Berestein, G., Sood, A. K., & Călin, G. A. (2011) · Nature Reviews Clinical Oncology · doi:10.1038/nrclinonc.2011.76 · Cited by 1,471 · see citing works

XBP1 links ER stress to intestinal inflammation and confers genetic risk for human inflammatory bowel disease

Kaser, A., Lee, A.-H., Franke, A., Glickman, J., Zeissig, S., Tilg, H., Nieuwenhuis, E., Higgins, D. E., Schreiber, S., Glimcher, L., et al. (2008) · Cell · doi:10.1016/j.cell.2008.07.021 · Cited by 1,442 · see citing works

The role of gut microbiota in immune homeostasis and autoimmunity

Wu, H.-J., & Wu, E. (2012) · Gut Microbes · doi:10.4161/gmic.19320 · Cited by 1,426 · see citing works

Low counts of Faecalibacterium prausnitzii in colitis microbiota

Sokol, H., Seksik, P., Furet, J. P., Firmesse, O., Nion-Larmurier, I., Beaugerie, L., Cosnes, J., Corthier, G., Marteau, P., & Doré, J. (2009) · Inflammatory Bowel Diseases · doi:10.1002/ibd.20903 · Cited by 1,275 · see citing works

Diet, gut microbiota and immune responses

Maslowski, K. M., & Mackay, C. R. (2011) · Nature Immunology · doi:10.1038/ni0111-5 · Cited by 1,261 · see citing works

Position statement. Part one: Immune function and exercise.

Walsh, N. P., Gleeson, M., Shephard, R. J., Gleeson, M., Woods, J. A., Bishop, N. C., Fleshner, M., Green, C., Pedersen, B. K., Hoffman-Goetz, L., et al. (2011) · PubMed · Cited by 1,250 · see citing works

Energy-balance studies reveal associations between gut microbes, caloric load, and nutrient absorption in humans

Jumpertz, R., Le, D. S., Turnbaugh, P. J., Trinidad, C., Bogardus, C., Gordon, J. I., & Krakoff, J. (2011) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.110.010132 · Cited by 1,232 · see citing works

Circulating MicroRNAs in Patients With Coronary Artery Disease

Fichtlscherer, S., Rosa, S. D., Fox, H., Schwietz, T., Fischer, A., Liebetrau, C., Weber, M. A., Hamm, C. W., Roexe, T., Müller-Ardogan, M., et al. (2010) · Circulation Research · doi:10.1161/circresaha.109.215566 · Cited by 1,222 · see citing works

Weight Reduction Increases Plasma Levels of an Adipose-Derived Anti-Inflammatory Protein, Adiponectin

Yang, W.-S., Lee, W.-J., Funahashi, T., Tanaka, S., Matsuzawa, Y., Chao, C.-L., Chen, C.-L., Tai, T.-Y., & Chuang, L.-M. (2001) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.86.8.3815 · Cited by 1,181 · see citing works

Differential Adaptation of Human Gut Microbiota to Bariatric Surgery–Induced Weight Loss

Furet, J.-P., Kong, L.-C., Tap, J., Poitou, C., Basdevant, A., Bouillot, J.-L., Mariat, D., Corthier, G., Doré, J., Henegar, C., et al. (2010) · Diabetes · doi:10.2337/db10-0253 · Cited by 1,173 · see citing works

Elevated Levels of Interleukin 6 Are Reduced in Serum and Subcutaneous Adipose Tissue of Obese Women after Weight Loss

Bastard, J., Jardel, C., Bruckert, É., Blondy, P., Capeau, J., Laville, M., Vidal, H., & Hainque, B. (2000) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jcem.85.9.6839 · Cited by 1,102 · see citing works

Dietary factors and low-grade inflammation in relation to overweight and obesity

Calder, P. C., Ahluwalia, N., Brouns, F., Buetler, T., Clement, K., Cunningham, K., Esposito, K., Jönsson, L. S., Kolb, H., Lansink, M., et al. (2011) · British Journal of Nutrition · doi:10.1017/s0007114511005460 · Cited by 1,098 · cited 2× · see citing works

A mitochondrial specific stress response in mammalian cells

Zhao, Q., Wang, J., Levichkin, I. V., Stasinopoulos, S., Ryan, M. T., & Hoogenraad, N. J. (2002) · The EMBO Journal · doi:10.1093/emboj/cdf445 · Cited by 1,026 · see citing works

Reduction of Inflammatory Cytokine Concentrations and Improvement of Endothelial Functions in Obese Women After Weight Loss Over One Year

Ziccardi, P., Nappo, F., Giugliano, G., Esposito, K., Marfella, R., Cioffi, M., D’Andrea, F., Molinari, A. M., & Giugliano, D. (2002) · Circulation · doi:10.1161/hc0702.104279 · Cited by 994 · see citing works

microRNA Regulation of Inflammatory Responses

O’Connell, R. M., Rao, D. S., & Baltimore, D. (2012) · Annual Review of Immunology · doi:10.1146/annurev-immunol-020711-075013 · Cited by 957 · see citing works

Skin microbiota: a source of disease or defence?

Cogen, A. L., Nizet, V., & Gallo, R. L. (2008) · British Journal of Dermatology · doi:10.1111/j.1365-2133.2008.08437.x · Cited by 954 · see citing works

Advantages and limitations of quantitative PCR (Q-PCR)-based approaches in microbial ecology

Smith, C. J., & Osborn, A. M. (2008) · FEMS Microbiology Ecology · doi:10.1111/j.1574-6941.2008.00629.x · Cited by 939 · see citing works

Inflammatory mediators in the elderly

Krabbe, K. S., Pedersen, M., & Bruunsgaard, H. (2004) · Experimental Gerontology · doi:10.1016/j.exger.2004.01.009 · Cited by 928 · see citing works

The origins of age-related proinflammatory state

Ferrucci, L., Corsi, A., Lauretani, F., Bandinelli, S., Bartali, B., Taub, D. D., Guralnik, J. M., & Longo, D. L. (2005) · Blood · doi:10.1182/blood-2004-07-2599 · Cited by 908 · see citing works

Probiotics and the gut microbiota in intestinal health and disease

Gareau, M. G., Sherman, P. M., & Walker, W. A. (2010) · Nature Reviews Gastroenterology &amp; Hepatology · doi:10.1038/nrgastro.2010.117 · Cited by 907 · see citing works

Involvement of gut microbiota in the development of low-grade inflammation and type 2 diabetes associated with obesity

Cani, P. D., Osto, M., Geurts, L., & Everard, A. (2012) · Gut Microbes · doi:10.4161/gmic.19625 · Cited by 864 · see citing works

Exercise and IL‐6 infusion inhibit endotoxin‐induced TNF‐α production in humans

Starkie, R., Ostrowski, S. R., Jauffred, S., Febbraio, M., & Pedersen, B. K. (2003) · The FASEB Journal · doi:10.1096/fj.02-0670fje · Cited by 790 · see citing works

High-throughput clone library analysis of the mucosa-associated microbiota reveals dysbiosis and differences between inflamed and non-inflamed regions of the intestine in inflammatory bowel disease

Walker, A. W., Sanderson, J. D., Churcher, C. M., Parkes, G. C., Hudspith, B. N., Rayment, N. B., Brostoff, J., Parkhill, J., Dougan, G., & Petrovska, L. (2011) · BMC Microbiology · doi:10.1186/1471-2180-11-7 · Cited by 727 · see citing works

Airway microbiota and bronchial hyperresponsiveness in patients with suboptimally controlled asthma

Huang, Y. J., Nelson, C. E., Brodie, E., DeSantis, T. Z., Baek, M. S., Liu, J., Woyke, T., Allgaier, M., Bristow, J., Wiener-Kronish, J. P., et al. (2010) · Journal of Allergy and Clinical Immunology · doi:10.1016/j.jaci.2010.10.048 · Cited by 693 · see citing works

Increased cytokine production in mononuclear cells of healthy elderly people

Fagiolo, U., Cossarizza, A., Scala, E., Fanales‐Belasio, E., Ortolani, C., Cozzi, E., Monti, D., Franceschi, C., & Paganelli, R. (1993) · European Journal of Immunology · doi:10.1002/eji.1830230950 · Cited by 665 · see citing works

Nutrigenomics: goals and strategies

Müller, M. M., & Kersten, S. (2003) · Nature Reviews Genetics · doi:10.1038/nrg1047 · Cited by 645 · see citing works

Heritable major histocompatibility complex class II-associated differences in production of tumor necrosis factor alpha: relevance to genetic predisposition to systemic lupus erythematosus.

Jacob, C. O., Fronek, Z., Lewis, G. D., Koo, M., Hansen, J. A., & McDevitt, H. O. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.3.1233 · Cited by 622 · see citing works

Metabolic adaptation to a high-fat diet is associated with a change in the gut microbiota

Sérino, M., Luche, É., Grès, S., Baylac, A., Bergé, M., Cénac, C., Waget, A., Klopp, P., Iacovoni, J. S., Klopp, C., et al. (2011) · Gut · doi:10.1136/gutjnl-2011-301012 · Cited by 621 · see citing works

Elevated C-Reactive Protein

Lemieux, I., Pascot, A., Prud’homme, D., Alméras, N., Bogaty, P. M., Nadeau, A., Bergeron, J., & Després, J. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.6.961 · Cited by 593 · see citing works

Vitamin E supplementation enhances cell-mediated immunity in healthy elderly subjects

Meydani, S. N., Barklund, M., Liu, S., Meydani, M., Miller, R. A., Cannon, J., Morrow, F. D., Rocklin, R. E., & Blumberg, J. B. (1990) · American Journal of Clinical Nutrition · doi:10.1093/ajcn/52.3.557 · Cited by 585 · see citing works

Inflammatory Disease Processes and Interactions with Nutrition

Calder, P. C., Albers, R., Antoine, J., Blum, S., Bourdet‐Sicard, R., Ferns, G. A., Folkerts, G., Friedmann, P. S., Frost, G. S., Guarner, F., et al. (2009) · British Journal Of Nutrition · doi:10.1017/s0007114509377867 · Cited by 570 · see citing works

Circulating MicroRNAs in Patients with Chronic Hepatitis C and Non-Alcoholic Fatty Liver Disease

Cermelli, S., Ruggieri, A., Marrero, J. A., Ioannou, G. N., & Beretta, L. (2011) · PLoS ONE · doi:10.1371/journal.pone.0023937 · Cited by 564 · see citing works

A genomic polymorphism within the tumor necrosis factor locus influences plasma tumor necrosis factor-alpha concentrations and outcome of patients with severe sepsis

Stuber, F. E., Petersen, M., Bokelmann, F., & Schade, U. F. (1996) · Critical Care Medicine · doi:10.1097/00003246-199603000-00004 · Cited by 549 · see citing works

Presence of the IL‐1RA Allele 2 (IL1RN*2) is Associated with Enhanced IL‐1β Production In Vitro

Santtila, Savinainen, K., & Hurme, M. (1998) · Scandinavian Journal of Immunology · doi:10.1046/j.1365-3083.1998.00300.x · Cited by 542 · see citing works

Weight Loss Reduces C-Reactive Protein Levels in Obese Postmenopausal Women

Tchernof, A., Nolan, A., Sites, C. K., Ades, P. A., & Poehlman, E. T. (2002) · Circulation · doi:10.1161/hc0502.103331 · Cited by 541 · see citing works

Postprandial Hyperglycemia/Hyperlipidemia (Postprandial Dysmetabolism) Is a Cardiovascular Risk Factor

O’Keefe, J. H., & Bell, D. S. H. (2007) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.03.107 · Cited by 538 · see citing works

Polymorphic structure of the tumor necrosis factor (TNF) locus: an NcoI polymorphism in the first intron of the human TNF-beta gene correlates with a variant amino acid in position 26 and a reduced level of TNF-beta production.

Messer, G., Spengler, U., Jung, M., Honold, G., Blömer, K., Pape, G. R., Riethmüller, G., & Weiss, E. H. (1991) · The Journal of Experimental Medicine · doi:10.1084/jem.173.1.209 · Cited by 537 · see citing works

Relationship Between Physical Activity and Inflammation Among Apparently Healthy Middle-aged and Older US Adults

Abramson, J. L., & Vaccarino, V. (2002) · Archives of Internal Medicine · doi:10.1001/archinte.162.11.1286 · Cited by 512 · see citing works

Circulating levels of MCP-1 and IL-8 are elevated in human obese subjects and associated with obesity-related parameters

Kim, C.-S., Park, H.-S., Kawada, T., Kim, J.-H., Lim, D., Hubbard, N. E., Kwon, B.-S., Erickson, K. L., & Yu, R. (2006) · International Journal of Obesity · doi:10.1038/sj.ijo.0803259 · Cited by 511 · see citing works

Metagenomic approaches for defining the pathogenesis of inflammatory bowel diseases

Peterson, D. A., Frank, D. N., Pace, N. R., & Gordon, J. I. (2008) · Cell Host &amp; Microbe · doi:10.1016/j.chom.2008.05.001 · Cited by 503 · see citing works

Physical Activity and Hemostatic and Inflammatory Variables in Elderly Men

Wannamethee, S. G., Lowe, G. D. O., Whincup, P. H., Rumley, A., Walker, M., & Lennon, L. (2002) · Circulation · doi:10.1161/01.cir.0000016346.14762.71 · Cited by 487 · see citing works

The Association of Plasma IL-6 Levels With Functional Disability in Community-Dwelling Elderly

Cohen, H. J., Pieper, C. F., Harris, T., Rao, K. M. K., & Currie, M. S. (1997) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/52a.4.m201 · Cited by 476 · see citing works

Intravital imaging

Pittet, M. J., & Weissleder, R. (2011) · Cell · doi:10.1016/j.cell.2011.11.004 · Cited by 466 · see citing works

The gut microbiota and its relationship to diet and obesity

Clarke, S. F., Murphy, E. F., Nilaweera, K. N., Ross, R. P., Shanahan, F., O’Toole, P. W., & Cotter, P. D. (2012) · Gut Microbes · doi:10.4161/gmic.20168 · Cited by 458 · see citing works

A High Plasma Concentration of TNF- Is Associated With Dementia in Centenarians

Brüünsgaard, H., Andersen‐Ranberg, K., Jeune, B., Pedersen, B. K., Skinhøj, P., & Pedersen, B. K. (1999) · The Journals of Gerontology Series A · doi:10.1093/gerona/54.7.m357 · Cited by 458 · see citing works

Epicardial fat: properties, function and relationship to obesity

Rabkin, S. W. (2006) · Obesity Reviews · doi:10.1111/j.1467-789x.2006.00293.x · Cited by 453 · see citing works

Association of physical activity and body mass index with novel and traditional cardiovascular biomarkers in women.

Mora, S., Lee, I., Buring, J., & Ridker, P. (2006) · Journal of the American Medical Association (JAMA) · doi:10.1001/jama.295.12.1412 · Cited by 451 · see citing works

Pathobionts of the gastrointestinal microbiota and inflammatory disease

Chow, J., Tang, H., & Mazmanian, S. K. (2011) · Current Opinion in Immunology · doi:10.1016/j.coi.2011.07.010 · Cited by 445 · see citing works

Diet-induced weight loss, exercise, and chronic inflammation in older, obese adults: a randomized controlled clinical trial

Nicklas, B. J., Ambrosius, W., Messier, S. P., Miller, G. D., Penninx, B. W., Loeser, R. F., Palla, S., Bleecker, E., & Pahor, M. (2004) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/79.4.544 · Cited by 443 · see citing works

The role of the intestinal microbiota in the development of atopic disorders

Penders, J., Stobberingh, E. E., van den Brandt, P. A., & Thijs, C. T. (2007) · Allergy · doi:10.1111/j.1398-9995.2007.01462.x · Cited by 435 · see citing works

Associations between cigarette smoking, pipe/cigar smoking, and smoking cessation, and haemostatic and inflammatory markers for cardiovascular disease

Wannamethee, S. G., Lowe, G. D. O., Shaper, A. G., Rumley, A., LENNON, L. T., & Whincup, P. H. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi183 · Cited by 430 · see citing works

Monocyte Cytokine Production in an Elderly Population: Effect of Age and Inflammation

Roubenoff, R., Harris, T. B., Abad, L. W., Wilson, P. W. F., Dallal, G. E., & Dinarello, C. A. (1998) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/53a.1.m20 · Cited by 418 · see citing works

Increased sensitivity to dextran sodium sulfate colitis in IRE1β-deficient mice

Bertolotti, A., Wang, X.-Z., Novoa, I., Jungreis, R., Schlessinger, K., Cho, J. H., West, A. B., & Ron, D. (2001) · Journal of Clinical Investigation · doi:10.1172/jci11476 · Cited by 412 · see citing works

Monocyte chemoattractant protein-1 is produced in isolated adipocytes, associated with adiposity and reduced after weight loss in morbid obese subjects

Christiansen, T., Richelsen, B., & Bruun, J. M. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802839 · Cited by 411 · see citing works

Interaction Between Obesity and the Gut Microbiota: Relevance in Nutrition

Delzenne, N. M., & Cani, P. D. (2011) · Annual Review of Nutrition · doi:10.1146/annurev-nutr-072610-145146 · Cited by 409 · see citing works

An Immune Risk Phenotype, Cognitive Impairment, and Survival in Very Late Life: Impact of Allostatic Load in Swedish Octogenarian and Nonagenarian Humans

Wikby, A., Ferguson, F., Forsey, R., Thompson, J., Strindhall, J., Löfgren, S., Nilsson, B.-O., Ernerudh, J., Pawelec, G., & Johansson, B. (2005) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/60.5.556 · Cited by 407 · see citing works

Relationship between Cigarette Smoking and Novel Risk Factors for Cardiovascular Disease in the United States

Bazzano, L., He, J., Muntner, P., Vupputuri, S. X., & Whelton, P. K. (2003) · Annals of Internal Medicine · doi:10.7326/0003-4819-138-11-200306030-00010 · Cited by 406 · see citing works

Human immunosenescence: is it infectious?

Pawelec, G., Akbar, A., Caruso, C., Solana, R., Grubeck‐Loebenstein, B., & Wikby, A. (2005) · Immunological Reviews · doi:10.1111/j.0105-2896.2005.00271.x · Cited by 405 · see citing works

Increase of plasma IL-6 concentration with age in healthy subjects

Wei, J., Xu, H., Davies, J. L., & Hemmings, G. P. (1992) · Life Sciences · doi:10.1016/0024-3205(92)90112-3 · Cited by 402 · see citing works

Age-dependent alterations of monocyte subsets and monocyte-related chemokine pathways in healthy adults

Seidler, S., Zimmermann, H. W., Bartneck, M., Trautwein, C., & Tacke, F. (2010) · BMC Immunology · doi:10.1186/1471-2172-11-30 · Cited by 390 · see citing works

Relation between markers of systemic vascular inflammation and smoking in women

Bermudez, E. A., Rifai, N., Buring, J. E., Manson, J. E., & Ridker, P. M. (2002) · The American Journal of Cardiology · doi:10.1016/s0002-9149(02)02284-1 · Cited by 385 · see citing works

Associations Between Cardiorespiratory Fitness and C-Reactive Protein in Men

Church, T. S., Barlow, C. E., Earnest, C. P., Kampert, J. B., Priest, E. L., & Blair, S. N. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000036611.77940.f8 · Cited by 382 · see citing works

Systemic low-grade inflammation is related to both circulating and adipose tissue TNFα, leptin and IL-6 levels in obese women

Maachi, M., Piéroni, L., Bruckert, É., Jardel, C., Fellahi, S., Hainque, B., Capeau, J., & Jp, B. (2004) · International Journal of Obesity · doi:10.1038/sj.ijo.0802718 · Cited by 379 · see citing works

Position statement. Part two: Maintaining immune health.

Walsh, N. P., Gleeson, M., Pyne, D. B., Nieman, D. C., Dhabhar, F. S., Shephard, R. J., Oliver, S. J., Bermon, S., & Kajėnienė, A. (2011) · PubMed · Cited by 365 · see citing works

Experimental Endotoxemia Induces Adipose Inflammation and Insulin Resistance in Humans

Mehta, N. N., McGillicuddy, F. C., Anderson, P. D., Hinkle, C. C., Shah, R. D., Pruscino, L., Tabita‐Martinez, J., Sellers, K. F., Rickels, M. R., & Reilly, M. P. (2009) · Diabetes · doi:10.2337/db09-0367 · Cited by 347 · see citing works

Neural Origins of Human Sickness in Interoceptive Responses to Inflammation

Harrison, N. A., Brydon, L., Walker, C., Gray, M. A., Steptoe, A., Dolan, R. J., & Critchley, H. D. (2009) · Biological Psychiatry · doi:10.1016/j.biopsych.2009.03.007 · Cited by 345 · see citing works

Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?

Franceschi, C. (2008) · Nutrition Reviews · doi:10.1111/j.1753-4887.2007.tb00358.x · Cited by 342 · see citing works

Association between cytomegalovirus infection, enhanced proinflammatory response and low level of anti-hemagglutinins during the anti-influenza vaccination—an impact of immunosenescence

Trzonkowski, P., Myśliwska, J. M., Szmit, E., Wickiewicz, J., Łukaszuk, K., Brydak, L. B., Machała, M. K., & Myśliwski, A. (2003) · Vaccine · doi:10.1016/s0264-410x(03)00309-8 · Cited by 341 · see citing works

Circulating MicroRNAs

Fichtlscherer, S., Zeiher, A. M., & Dimmeler, S. (2011) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.111.226696 · Cited by 341 · see citing works

Cytomegalovirus and human immunosenescence

Pawelec, G., Derhovanessian, E., Larbi, A., Strindhall, J., & Wikby, A. (2008) · Reviews in Medical Virology · doi:10.1002/rmv.598 · Cited by 339 · see citing works

Fish-oil supplementation induces antiinflammatory gene expression profiles in human blood mononuclear cells

Bouwens, M., van de Rest, O., Dellschaft, N. S., Bromhaar, M. G., de Groot, C. P. G. M., Geleijnse, J. M., Müller, M. M., & Afman, L. A. (2009) · American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27680 · Cited by 335 · see citing works

Involvement of tissue bacteria in the onset of diabetes in humans: evidence for a concept

for the D.E.S.I.R. Study Group, Amar, J., Sérino, M., Lange, C., Chabo, C., Iacovoni, J. S., Mondot, S., Lepage, P., Klopp, C., Mariette, J., et al. (2011) · Diabetologia · doi:10.1007/s00125-011-2329-8 · Cited by 327 · see citing works

Aging of the Immune System as a Prognostic Factor for Human Longevity

Larbi, A., Franceschi, C., Mazzatti, D. J., Solana, R., Wikby, A., & Pawelec, G. (2008) · Physiology · doi:10.1152/physiol.00040.2007 · Cited by 316 · see citing works

Immune Dysregulation and Chronic Stress among Older Adults: A Review

Gouin, J.-P., Hantsoo, L. V., & Kiecolt‐Glaser, J. K. (2008) · NeuroImmunoModulation · doi:10.1159/000156468 · Cited by 312 · see citing works

Leukocyte Count as a Predictor of Cardiovascular Events and Mortality in Postmenopausal Women

Margolis, K. L. (2005) · Archives of Internal Medicine · doi:10.1001/archinte.165.5.500 · Cited by 310 · see citing works

Inflammaging as a Major Characteristic of Old People: Can It Be Prevented or Cured?

Franceschi, C. (2007) · Nutrition Reviews · doi:10.1301/nr.2007.dec.s173-s176 · Cited by 306 · see citing works

Mechanisms of Inflammatory Responses in Obese Adipose Tissue

Sun, S.-Y., Ji, Y.-W., Kersten, S., & Qi, L. (2012) · Annual review of nutrition · doi:10.1146/annurev-nutr-071811-150623 · Cited by 303 · see citing works

Reduction in C-reactive protein through cardiac rehabilitation and exercise training

Milani, R. V., Lavie, C. J., & Mehra, M. R. (2004) · Journal of the American College of Cardiology · doi:10.1016/j.jacc.2003.10.041 · Cited by 302 · see citing works

Effect of Atorvastatin and Irbesartan, Alone and in Combination, on Postprandial Endothelial Dysfunction, Oxidative Stress, and Inflammation in Type 2 Diabetic Patients

Ceriello, A., Assaloni, R., Da Ros, R., Maier, A., Piconi, L., Quagliaro, L., Esposito, K., & Giugliano, D. (2005) · Circulation · doi:10.1161/01.cir.0000165070.46111.9f · Cited by 298 · see citing works

Physical Activity and Hemostatic and Inflammatory Variables in Elderly Men

Wannamethee, S. G. (2002) · Circulation · doi:10.1161/hc1502.107117 · Cited by 296 · see citing works

Independent association of various smoking characteristics with markers of systemic inflammation in menResults from a representative sample of the general population (MONICA Augsburg Survey 1994/95)

FROHLICH, M. (2003) · European Heart Journal · doi:10.1016/s0195-668x(03)00260-4 · Cited by 294 · see citing works

A saturated fatty acid–rich diet induces an obesity-linked proinflammatory gene expression profile in adipose tissue of subjects at risk of metabolic syndrome

van Dijk, S. J., Feskens, E. J., Bos, M. B., Hoelen, D. W., Heijligenberg, R., Bromhaar, M. G., de Groot, L. C., de Vries, J. H., Müller, M., & Afman, L. A. (2009) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.27792 · Cited by 291 · see citing works

IL-1 receptor antagonist serum levels are increased in human obesity: a possible link to the resistance to leptin?

Meier, C. A., Bobbioni, E., Gabay, C., Assimacopoulos-Jeannet, F., Golay, A., & Dayer, J.-M. (2002) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jcem.87.3.8351 · Cited by 287 · see citing works

Acute inflammation and negative mood: mediation by cytokine activation

Wright, C. E., Strike, P. C., Brydon, L., & Steptoe, A. (2005) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2004.10.003 · Cited by 287 · see citing works

Nutrigenomics: From Molecular Nutrition to Prevention of Disease

Afman, L. A., & Müller, M. M. (2006) · Journal of the American Dietetic Association · doi:10.1016/j.jada.2006.01.001 · Cited by 286 · see citing works

The immune risk phenotype is associated with IL-6 in the terminal decline stage: Findings from the Swedish NONA immune longitudinal study of very late life functioning

Wikby, A., Nilsson, B.-O., Forsey, R. J., Thompson, J., Strindhall, J., Löfgren, S., Ernerudh, J., Pawelec, G., Ferguson, F. G., & Johansson, B. E. A. (2006) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2006.04.003 · Cited by 284 · see citing works

Plasma Interleukin-8 Concentrations Are Increased in Obese Subjects and Related to Fat Mass and Tumor Necrosis Factor-α System

Straczkowski, M., Dzienis-Straczkowska, S., Stêpieñ, A., Kowalska, I., Szelachowska, M., & Kinalska, I. (2002) · The Journal of Clinical Endocrinology &amp; Metabolism · doi:10.1210/jc.2002-020135 · Cited by 280 · see citing works

Peripheral blood dendritic cells and monocytes are differently regulated in the elderly

Bella, S. D., Bierti, L., Presicce, P., Arienti, R., Valenti, M., Saresella, M., Vergani, C., & Villa, M. L. (2006) · Clinical Immunology · doi:10.1016/j.clim.2006.09.012 · Cited by 280 · see citing works

Human endotoxemia as a model of systemic inflammation

Andreasen, A., Krabbe, K., Krogh-Madsen, R., Taudorf, S., Pedersen, B., & Moller, K. (2008) · Current Medicinal Chemistry · doi:10.2174/092986708784872393 · Cited by 271 · see citing works

Visceral Fat Is a Negative Predictor of Bone Density Measures in Obese Adolescent Girls

Russell, M., Mendes, N., Miller, K. K., Rosen, C. J., Lee, H., Klibanski, A., & Bredella, M. A. (2010) · The Journal of Clinical Endocrinology & Metabolism · doi:10.1210/jc.2009-1475 · Cited by 259 · see citing works

Molecular Analysis of Fungal Microbiota in Samples from Healthy Human Skin and Psoriatic Lesions

Paulino, L. C., Tseng, C., Strober, B. E., & Blaser, M. J. (2006) · Journal of Clinical Microbiology · doi:10.1128/jcm.00785-06 · Cited by 258 · see citing works

Circulating Heat Shock Protein 60 Is Associated With Early Cardiovascular Disease

Pockley, A. G., Wu, R., Lemne, C. E., Kiessling, R. W., Fairé, U. D., & Frostegård, J. (2000) · Hypertension · doi:10.1161/01.hyp.36.2.303 · Cited by 257 · see citing works

Microbial phylogeny and diversity: Small subunit ribosomal RNA sequence analysis and beyond

Rajendhran, J., & Gunasekaran, P. (2010) · Microbiological Research · doi:10.1016/j.micres.2010.02.003 · Cited by 256 · see citing works

Exercise training is not associated with improved levels of C-reactive protein or adiponectin

MARCELL, T. J., McAuley, K. A., Traustadóttir, T., & Reaven, P. D. (2005) · Metabolism · doi:10.1016/j.metabol.2004.11.008 · Cited by 256 · see citing works

Benefits of massive weight loss on symptoms, systemic inflammation and cartilage turnover in obese patients with knee osteoarthritis

Richette, P., Poitou, C., Garnero, P., Vicaut, É., Bouillot, J., Lacorte, J., Basdevant, A., Clément, K., Bardin, T., & Chevalier, X. (2010) · Annals of the Rheumatic Diseases · doi:10.1136/ard.2010.134015 · Cited by 254 · see citing works

How can we measure insulin sensitivity/resistance?

Antuna-Puente, B., Disse, E., RABASA-LHORET, R. P. R., Laville, M., Capeau, J., & Bastard, J. (2011) · Diabetes & Metabolism · doi:10.1016/j.diabet.2011.01.002 · Cited by 253 · see citing works

Immunity as a link between obesity and insulin resistance

Kalupahana, N. S., Moustaïd‐Moussa, N., & Claycombe, K. (2011) · Molecular Aspects of Medicine · doi:10.1016/j.mam.2011.10.011 · Cited by 253 · see citing works

An antiinflammatory dietary mix modulates inflammation and oxidative and metabolic stress in overweight men: a nutrigenomics approach

Bakker, G. C., van Erk, M. J., Pellis, L., Wopereis, S., Rubingh, C. M., Cnubben, N. H., Kooistra, T., van Ommen, B., & Hendriks, H. F. (2010) · The American Journal of Clinical Nutrition · doi:10.3945/ajcn.2009.28822 · Cited by 252 · see citing works

Plasma cytokine profiles in elderly humans

Forsey, R. J., Thompson, J. M., Ernerudh, J., HURST, T. L., Strindhall, J., Johansson, B. E. A., Nilsson, B.-O., & Wikby, A. (2003) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(03)00025-3 · Cited by 249 · see citing works

Gender Difference in the Non‐Specific and Specific Immune Response in Humans

Bouman, A., Schipper, M., Heineman, M. J., & Faas, M. M. (2004) · American Journal of Reproductive Immunology · doi:10.1111/j.1600-0897.2004.00177.x · Cited by 249 · see citing works

Leisure-time physical activity and reduced plasma levels of obesity-related inflammatory markers

Pischon, T., Hankinson, S. E., Hotamisligil, G. S., Rifai, N., & Rimm, E. B. (2003) · Obesity Research · doi:10.1038/oby.2003.145 · Cited by 245 · see citing works

In the Elderly, Interleukin-6 Plasma Levels and the −174G>C Polymorphism Are Associated With the Development of Cardiovascular Disease

Jenny, N. S., Tracy, R. P., Ogg, M. S., Luong, L. A., Kuller, L. H., Arnold, A. M., Sharrett, A. R., & Humphries, S. E. (2002) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000040224.49362.60 · Cited by 243 · see citing works

Mild Depressive Symptoms Are Associated With Amplified and Prolonged Inflammatory Responses After Influenza Virus Vaccination in Older Adults

Glaser, R., Robles, T. F., Sheridan, J. F., Malarkey, W. B., & Kiecolt‐Glaser, J. K. (2003) · Archives of General Psychiatry · doi:10.1001/archpsyc.60.10.1009 · Cited by 242 · see citing works

A Persistent and Diverse Airway Microbiota Present during Chronic Obstructive Pulmonary Disease Exacerbations

Huang, Y. J., Kim, E., Cox, M. J., Brodie, E., Brown, R., Wiener-Kronish, J. P., & Lynch, S. V. (2010) · OMICS A Journal of Integrative Biology · doi:10.1089/omi.2009.0100 · Cited by 241 · see citing works

Multiple Markers of Inflammation and Weight Status: Cross-sectional Analyses Throughout Childhood

Skinner, A. C., Steiner, M. J., Henderson, F. W., & Perrin, E. M. (2010) · PEDIATRICS · doi:10.1542/peds.2009-2182 · Cited by 237 · see citing works

Epigenetic regulation of gene expression in the inflammatory response and relevance to common diseases.

Wilson, A. (2008) · The Journal of Periodontology · doi:10.1902/jop.2008.080172 · Cited by 232 · see citing works

Effect of a short-term diet and exercise intervention on oxidative stress, inflammation, MMP-9, and monocyte chemotactic activity in men with metabolic syndrome factors

Roberts, C. K., Won, D., Pruthi, S., Kurtovic, S., Sindhu, R. K., Vaziri, N. D., & Barnard, R. J. (2005) · Journal of Applied Physiology · doi:10.1152/japplphysiol.01292.2005 · Cited by 232 · see citing works

Increased leptin concentrations correlate with increased concentrations of inflammatory markers in morbidly obese individuals

van Dielen, F., Veer, C. V. ′., Schols, A. M. W. J., Soeters, P. B., Buurman, W. A., & Greve, J.-W. M. (2001) · International Journal of Obesity · doi:10.1038/sj.ijo.0801825 · Cited by 231 · see citing works

The inflammatory status of old age can be nurtured from the intestinal environment

Guigoz, Y., Dore, J. M., & Schiffrin, E. J. (2008) · Current Opinion in Clinical Nutrition & Metabolic Care · doi:10.1097/mco.0b013e3282f2bfdf · Cited by 224 · see citing works

NUTRITIONAL GENOMICS

Ordovás, J. M., & Corella, D. (2004) · Annual Review of Genomics and Human Genetics · doi:10.1146/annurev.genom.5.061903.180008 · Cited by 224 · see citing works

A legume-based hypocaloric diet reduces proinflammatory status and improves metabolic features in overweight/obese subjects

Hermsdorff, H. H. M., Zulet, M. Á., Abete, I., & Martínez, J. A. (2011) · European Journal of Nutrition · doi:10.1007/s00394-010-0115-x · Cited by 223 · see citing works

Biomarkers of human immunosenescence: impact of cytomegalovirus infection

Derhovanessian, E., Larbi, A., & Pawelec, G. (2009) · Current Opinion in Immunology · doi:10.1016/j.coi.2009.05.012 · Cited by 220 · see citing works

A genetic association between systemic lupus erythematosus and tumor necrosis factor alpha

Wilson, A. G., Gordon, C., di Giovine, F. S., et al. (1994) · European Journal of Immunology · doi:10.1002/eji.1830240130 · Cited by 219 · see citing works

No Immune Risk Profile among individuals who reach 100 years of age: Findings from the Swedish NONA immune longitudinal study

Strindhall, J., Nilsson, B.-O., Löfgren, S., Ernerudh, J., Pawelec, G., Johansson, B., & Wikby, A. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.05.001 · Cited by 209 · see citing works

Advancing age and insulin resistance: role of plasma tumor necrosis factor-α

Paolisso, G., Rizzo, M. R., Mazziotti, G., Tagliamonte, M. R., Gambardella, A., Rotondi, M., Carella, C., Giugliano, D., Varricchio, M., & D’Onofrio, F. (1998) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.1998.275.2.e294 · Cited by 208 · see citing works

Effect of exercise training on plasma levels of C-reactive protein in healthy adults: the HERITAGE Family Study

Lakka, T. A., Lakka, H.-M., Rankinen, T., Leon, A. S., Rao, D. C., Skinner, J. S., Wilmore, J. H., & Bouchard, C. (2005) · European Heart Journal · doi:10.1093/eurheartj/ehi394 · Cited by 206 · see citing works

Serologic Markers in Inflammatory Bowel Disease

Bossuyt, X. (2005) · Clinical Chemistry · doi:10.1373/clinchem.2005.058560 · Cited by 205 · see citing works

Probiotics, Immune Function, Infection and Inflammation: A Review of the Evidence from Studies Conducted in Humans

Lomax, A. E., & Calder, P. C. (2009) · Current Pharmaceutical Design · doi:10.2174/138161209788168155 · Cited by 203 · see citing works

Adipokines: Biofactors from white adipose tissue. A complex hub among inflammation, metabolism, and immunity

Conde, J., Scotece, M., Gómez, R., López, V., Gómez-Reino, J. J., Lago, F., & Gualillo, O. (2011) · BioFactors · doi:10.1002/biof.185 · Cited by 200 · see citing works

C-Reactive Protein, Fibrin D-Dimer, and Incident Ischemic Heart Disease in the Speedwell Study

Lowe, G. D. O., YARNELL, J. W. G., Rumley, A., Bainton, D., & Sweetnam, P. M. (2001) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.21.4.603 · Cited by 199 · see citing works

Inflammatory Markers and Exercise: Differences Related to Exercise Type

King, D. E., Carek, P. J., Mainous, A. G., & Pearson, W. S. (2003) · Medicine & Science in Sports & Exercise · doi:10.1249/01.mss.0000058440.28108.cc · Cited by 194 · see citing works

Systemic Response to Ambient Particulate Matter: Relevance to Chronic Obstructive Pulmonary Disease

van Eeden, S. F., Yeung, A., Quinlam, K., & Hogg, J. C. (2005) · Proceedings of the American Thoracic Society · doi:10.1513/pats.200406-035ms · Cited by 193 · see citing works

Adipose Tissue Dysfunction Signals Progression of Hepatic Steatosis Towards Nonalcoholic Steatohepatitis in C57Bl/6 Mice

Duval, C., Thissen, U., Keshtkar, S., Accart, B., Stienstra, R., Boekschoten, M. V., Roskams, T., Kersten, S., & Müller, M. M. (2010) · Diabetes · doi:10.2337/db10-0224 · Cited by 187 · see citing works

Untitled work

(2009) · PubMed · Cited by 183 · see citing works

The role of the small intestine in the development of dietary fat-induced obesity and insulin resistance in C57BL/6J mice

de Wit, N. J., Bosch-Vermeulen, H., de Groot, P. J., Hooiveld, G. J., Bromhaar, M. M. G., Jansen, J., Müller, M., & van der Meer, R. (2008) · BMC Medical Genomics · doi:10.1186/1755-8794-1-14 · Cited by 182 · see citing works

Epicardial Adipose Tissue Extent: Relationship With Age, Body Fat Distribution, and Coronaropathy

Silaghi, A., Piercecchi‐Marti, M., Grino, M., Leonetti, G., Alessi, M. C., Clement, K., Dadoun, F., & Dutour, A. (2008) · Obesity · doi:10.1038/oby.2008.379 · Cited by 181 · see citing works

Inflammation, genetics, and longevity: further studies on the protective effects in men of IL-10 −1082 promoter SNP and its interaction with TNF-α −308 promoter SNP

Lio, D., Scola, L., Crivello, A., Colonna-Romano, G., Candore, G., Bonafé, M., Cavallone, L., Marchegiani, F., Olivieri, F., Franceschi, C., et al. (2003) · Journal of Medical Genetics · doi:10.1136/jmg.40.4.296 · Cited by 181 · see citing works

Circulating heat shock protein and heat shock protein antibody levels in established hypertension

Pockley, A. G., Fairé, U. D., Kiessling, R. W., Lemne, C. E., Thulin, T., & Frostegård, J. (2002) · Journal of Hypertension · doi:10.1097/00004872-200209000-00027 · Cited by 179 · see citing works

Age-Related Changes in Eosinophil Function in Human Subjects

Mathur, S. K., Schwantes, E. A., Jarjour, N. N., & Busse, W. W. (2008) · CHEST Journal · doi:10.1378/chest.07-2114 · Cited by 179 · see citing works

The associations between leisure-time physical activity and inflammatory and coagulation markers related to cardiovascular disease: the ATTICA Study

Panagiotakos, D. B., Pitsavos, C. S., Chrysohoou, C. A., Kavouras, S. A., & Stefanadis, C. (2004) · Preventive Medicine · doi:10.1016/j.ypmed.2004.07.010 · Cited by 174 · see citing works

Interleukin-6 and selected plasma proteins in healthy persons of different ages

Häger, K., Machein, U., Krieger, S., Platt, D., Seefried, G., & Bauer, J. (1994) · Neurobiology of Aging · doi:10.1016/0197-4580(94)90066-3 · Cited by 172 · see citing works

Gene-environment interactions in chronic inflammatory disease

Renz, H., von Mutius, E., Brandtzaeg, P., Cookson, W., Autenrieth, I., & Haller, D. (2011) · Nature Immunology · doi:10.1038/ni0411-273 · Cited by 170 · see citing works

Interleukin-6 Production Does Not Increase With Age

Beharka, A. A., Meydani, M., Wu, D., Leka, L. S., Meydani, A., & Meydani, S. N. (2001) · The Journals of Gerontology Series A: Biological Sciences and Medical Sciences · doi:10.1093/gerona/56.2.b81 · Cited by 169 · see citing works

Challenging homeostasis to define biomarkers for nutrition related health

van Ommen, B., Keijer, J., Heil, S. G., & Kaput, J. (2009) · Molecular Nutrition &amp; Food Research · doi:10.1002/mnfr.200800390 · Cited by 167 · see citing works

Quantitative and Qualitative Alterations of Acute-phase Proteins in Healthy Elderly Persons

Ballou, S. P., LOZANSKI, G. B., Hodder, S., Rzewnicki, D., MION, L. C., Sipe, J. D., Ford, A. B., & Kushner, I. (1996) · Age and Ageing · doi:10.1093/ageing/25.3.224 · Cited by 167 · see citing works

Active smoking and a history of smoking are associated with enhanced prostaglandin F2α, interleukin-6 and F2-isoprostane formation in elderly men

Helmersson, J., Larsson, A. O., Vessby, B., & Basu, S. (2005) · Atherosclerosis · doi:10.1016/j.atherosclerosis.2004.11.026 · Cited by 166 · see citing works

Circulating MicroRNA Is a Biomarker of Pediatric Crohn Disease

Zahm, A. M., Thayu, M., Hand, N. J., Horner, A. M., Leonard, M. B., & Friedman, J. R. (2011) · Journal of Pediatric Gastroenterology and Nutrition · doi:10.1097/mpg.0b013e31822200cc · Cited by 165 · see citing works

Endurance training reduces the contraction-induced interleukin-6 mRNA expression in human skeletal muscle

Fischer, C. P., Plomgaard, P., Hansen, A. K., Pilegaard, H., Saltin, B., & Pedersen, B. K. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00206.2004 · Cited by 165 · see citing works

Synergistic effects of psychological and immune stressors on inflammatory cytokine and sickness responses in humans

Brydon, L., Walker, C., Wawrzyniak, A., Whitehead, D., Okamura, H., Yajima, J., Tsuda, A., & Steptoe, A. (2009) · Brain, Behavior, and Immunity · doi:10.1016/j.bbi.2008.09.007 · Cited by 164 · see citing works

Chemokines, sTNF-Rs and sCD30 serum levels in healthy aged people and centenarians

Gerli, R., Monti, D., Bistoni, O., M. Mazzone, A., Peri, G., Cossarizza, A., Di Gioacchino, M., E. F. Cesarotti, M., Doni, A., Mantovani, A., et al. (2001) · Mechanisms of Ageing and Development · doi:10.1016/s0047-6374(00)00195-0 · Cited by 162 · see citing works

Increased tumour necrosis factor‐α plasma levels during moderate-intensity exercise in COPD patients

Rabinovich, R., Figueras, M., Ardite, E., Carbó, N., Troosters, T., Filella, X., Barberà, J. A., Fernández-Checa, J. C., Argilés, J. M. A., & Roca, J. (2003) · European Respiratory Journal · doi:10.1183/09031936.03.00042702 · Cited by 161 · see citing works

Epigenetics in atherosclerosis and inflammation

Wierda, R. J., Geutskens, S. B., Jukema, J. W., Quax, P. H. A., & van den Elsen, P. J. (2010) · Journal of Cellular and Molecular Medicine · doi:10.1111/j.1582-4934.2010.01022.x · Cited by 160 · see citing works

Associations of blood rheology and interleukin‐6 with cardiovascular risk factors and prevalent cardiovascular disease

Woodward, M., Rumley, A., Tunstall‐Pedoe, H., & Lowe, G. D. O. (1999) · British Journal of Haematology · doi:10.1046/j.1365-2141.1999.01158.x · Cited by 160 · see citing works

Specialized proresolving mediator targets for RvE1 and RvD1 in peripheral blood and mechanisms of resolution

Fredman, G., & Serhan, C. N. (2011) · Biochemical Journal · doi:10.1042/bj20110327 · Cited by 159 · see citing works

Induction of dsRNA-activated protein kinase links mitochondrial unfolded protein response to the pathogenesis of intestinal inflammation

Rath, E., Berger, E., Messlik, A., Nunes, T., Liu, B., Kim, S. C., Hoogenraad, N. J., Sans, M., Sartor, R. B., & Haller, D. (2011) · Gut · doi:10.1136/gutjnl-2011-300767 · Cited by 154 · see citing works

Lifestyle and Hemostatic Risk Factors for Ischemic Heart Disease

YARNELL, J. W. G., Sweetnam, P. M., Rumley, A., & Lowe, G. D. O. (2000) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.20.1.271 · Cited by 151 · see citing works

Genetics of tumour necrosis factor-alpha in autoimmune, infectious, and neoplastic diseases.

Wilson, A. G., di Giovine, F. S., & Duff, G. W. (1995) · PubMed · Cited by 151 · see citing works

Coupling mitochondrial dysfunction to endoplasmic reticulum stress response: A molecular mechanism leading to hepatic insulin resistance

LIM, J., Lee, H., HOJUNG, M., & Song, J. (2008) · Cellular Signalling · doi:10.1016/j.cellsig.2008.10.004 · Cited by 149 · see citing works

Bidirectional Communication between the Brain and the Immune System: Implications for Physiological Sleep and Disorders with Disrupted Sleep

Lorton, D., Lubahn, C. L., Estus, C., Millar, B. A., Carter, J. L., Wood, C. A., & Bellinger, D. L. (2006) · NeuroImmunoModulation · doi:10.1159/000104864 · Cited by 147 · see citing works

Hemostasis factors and aging

Mari, D., Coppola, R., & Provenzano, R. (2007) · Experimental Gerontology · doi:10.1016/j.exger.2007.06.014 · Cited by 147 · see citing works

Relationship Between Inflammation, Insulin Resistance and Type 2 Diabetes: Cause or Effect?

Greenfield, J. R., & Campbell, L. V. (2006) · Current Diabetes Reviews · doi:10.2174/157339906776818532 · Cited by 147 · see citing works

Liver-specific loss of glucose-regulated protein 78 perturbs the unfolded protein response and exacerbates a spectrum of liver diseases in mice

Ji, C., Kaplowitz, N., Lau, M. Y., Kao, E., Petrovic, L. M., & Lee, A. S. (2011) · Hepatology · doi:10.1002/hep.24368 · Cited by 145 · see citing works

Serum concentrations of proinflammatory cytokines in Graves' disease: effect of treatment, thyroid function, ophthalmopathy and cigarette smoking

Salvi, M., Pedrazzoni, M., Girasole, G., Giuliani, N., Minelli, R., Wall, & Roti, E. (2000) · European Journal of Endocrinology · doi:10.1530/eje.0.1430197 · Cited by 143 · see citing works

An Interleukin‐1 Genotype Is Associated with Fatal Outcome of Meningococcal Disease

Read, R. C., Camp, N. J., di Giovine, F., et al. (2000) · The Journal of Infectious Diseases · doi:10.1086/315889 · Cited by 143 · see citing works

Effect of 50- and 100-mg vitamin E supplements on cellular immune function in noninstitutionalized elderly persons

Pallast, E. G., Schouten, E. G., de Waart, F. G., Fonk, H. C., Doekes, G., von Blomberg, B. M., & Kok, F. J. (1999) · The American Journal of Clinical Nutrition · doi:10.1093/ajcn/69.6.1273 · Cited by 141 · see citing works

Serum leptin levels in relation to circulating cytokines, chemokines, adhesion molecules and angiogenic factors in normal pregnancy and preeclampsia

Molvarec, A., Szarka, A., Walentin, S., Bekő, G., Karádi, I., Prohászka, Z., & Rigó, J. J. (2011) · Reproductive Biology and Endocrinology · doi:10.1186/1477-7827-9-124 · Cited by 139 · see citing works

CD11c Expression in Adipose Tissue and Blood and Its Role in Diet-Induced Obesity

Wu, H., Perrard, X. D., Wang, Q., Perrard, J. L., Polsani, V. R., Jones, P. H., Smith, C. W., & Ballantyne, C. M. (2009) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/atvbaha.109.198044 · Cited by 138 · see citing works

Plasma cytokine response during the postprandial period: a potential causal process in vascular disease?

Burdge, G. C., & Calder, P. C. (2005) · British Journal Of Nutrition · doi:10.1079/bjn20041282 · Cited by 136 · see citing works

The relative influences of fitness and fatness on inflammatory factors

Hamer, M. (2006) · Preventive Medicine · doi:10.1016/j.ypmed.2006.09.005 · Cited by 132 · see citing works

Effect of hyperglycemia and hyperinsulinemia on the response of IL-6, TNF-α, and FFAs to low-dose endotoxemia in humans

Krogh‐Madsen, R., Møller, K., Dela, F., Kronborg, G., Jauffred, S., & Pedersen, B. K. (2004) · American Journal of Physiology-Endocrinology and Metabolism · doi:10.1152/ajpendo.00468.2003 · Cited by 129 · see citing works

Differential Expression of Chemokines, Risk of Stable Coronary Heart Disease, and Correlation with Established Cardiovascular Risk Markers

Rothenbacher, D., Müller-Scholze, S., Herder, C., et al. (2005) · Arteriosclerosis Thrombosis and Vascular Biology · doi:10.1161/01.atv.0000191633.52585.14 · Cited by 128 · see citing works

Minireview: Nanoparticles for Molecular Imaging—An Overview

Minchin, R. F., & Martin, D. J. (2009) · Endocrinology · doi:10.1210/en.2009-1012 · Cited by 126 · see citing works

Elevated Concentrations of Soluble E-Selectin and Vascular Cell Adhesion Molecule-1 in NIDDM: Effect of intensive insulin treatment

Albertini, J., Valensi, P. E., Lormeau, B., Aurousseau, M. H., Ferrière, F., Attali, J. R., & Gattegno, L. (1998) · Diabetes Care · doi:10.2337/diacare.21.6.1008 · Cited by 124 · see citing works

Metabolic Profiling of the Response to an Oral Glucose Tolerance Test Detects Subtle Metabolic Changes

Wopereis, S., Rubingh, C. M., van Erk, M. J., Verheij, E. R., van Vliet, T., Cnubben, N. H. P., Smilde, A. K., van der Greef, J., van Ommen, B., & Hendriks, H. F. J. (2009) · PLoS ONE · doi:10.1371/journal.pone.0004525 · Cited by 123 · see citing works

Exposure to Secondhand Smoke and Biomarkers of Cardiovascular Disease Risk in Never-Smoking Adults

Venn, A. J., & Britton, J. R. (2007) · Circulation · doi:10.1161/circulationaha.106.648469 · Cited by 122 · see citing works

Comparative quantification of IL-1β, IL-10, IL-10r, TNFα and IL-7 mRNA levels in UV-irradiated human skin in vivo

Brink, N., Szamel, M., Young, A. R., Wittern, K., & Bergemann, J. (2000) · Inflammation Research · doi:10.1007/pl00000209 · Cited by 121 · see citing works

The sunburn response in human skin is characterized by sequential eicosanoid profiles that may mediate its early and late phases

Rhodes, L. E., Gledhill, K., Masoodi, M., Haylett, A. K., Brownrigg, M., Thody, A. J., Tobin, D. J., & Nicolaou, A. (2009) · The FASEB Journal · doi:10.1096/fj.09-136077 · Cited by 118 · see citing works

Effects of Acute Mental Stress and Exercise on Inflammatory Markers in Patients With Coronary Artery Disease and Healthy Controls

Kop, W. J., Weissman, N. J., Zhu, J., Bonsall, R. W., Doyle, M. F., Stretch, M. R., Glaes, S. B., Krantz, D. S., Gottdiener, J. S., & Tracy, R. P. (2008) · The American Journal of Cardiology · doi:10.1016/j.amjcard.2007.11.006 · Cited by 117 · see citing works

Association between serum amyloid A and obesity: a meta-analysis and systematic review

Zhao, Y., He, X., Shi, X., Huang, C. M., Liu, J., Zhou, S., & Heng, C. (2010) · Inflammation Research · doi:10.1007/s00011-010-0163-y · Cited by 115 · see citing works

Relationship between plasma leptin levels and the tumor necrosis factor-α system in obese subjects

Corica, F., Allegra, A., Corsonello, A., Buemi, M., Calapai, G., Ruello, A., Mauro, V. N., & Ceruso, D. (1999) · International Journal of Obesity · doi:10.1038/sj.ijo.0800826 · Cited by 112 · see citing works

Glucose challenge test for detecting gestational diabetes mellitus: a systematic review

van Leeuwen, M., Louwerse, M., Opmeer, B., Limpens, J., Serlie, M., Reitsma, J., & Mol, B. (2012) · BJOG: An International Journal of Obstetrics &amp; Gynaecology · doi:10.1111/j.1471-0528.2011.03254.x · Cited by 110 · see citing works

The effect of age and gender on cytokine production by human peripheral blood mononuclear cells and markers of bone metabolism

Pietschmann, P., Gollob, E., Brosch, S., Hahn, P., Kudlacek, S. T., Willheim, M., Woloszczuk, W., Peterlik, M., & Tragl, K. H. (2003) · Experimental Gerontology · doi:10.1016/s0531-5565(03)00189-x · Cited by 109 · see citing works

Cytokine profile in human skin in response to experimental inflammation, noxious stimulation, and administration of a COX-inhibitor: A microdialysis study

Angst, M. S., Clark, J. D., Carvalho, B., Tingle, M. S., Schmelz, M., & Yeomans, D. C. (2008) · Pain · doi:10.1016/j.pain.2008.02.028 · Cited by 109 · see citing works

Visualization and identification of health space, based on personalized molecular phenotype and treatment response to relevant underlying biological processes

Bouwman, J., Vogels, J., Wopereis, S., et al. (2012) · BMC Medical Genomics · doi:10.1186/1755-8794-5-1 · Cited by 109 · see citing works

Chronic inflammation in the etiology of disease across the life span

Furman, D., Campisi, J., Verdin, E., Carrera-Bastos, P., Targ, S., Franceschi, C., Ferrucci, L., Gilroy, D. W., Fasano, A., Miller, G. W., et al. (2019) · Nature Medicine · doi:10.1038/s41591-019-0675-0 · Cited by 4,915 · see citing works

Marine omega-3 fatty acids and inflammatory processes: effects, mechanisms and clinical relevance

Calder, P. C. (2015) · Biochimica et Biophysica Acta (BBA) - Molecular and Cell Biology of Lipids · doi:10.1016/j.bbalip.2014.08.010 · Cited by 1,717 · see citing works

Impact of Diet-Modulated Butyrate Production on Intestinal Barrier Function and Inflammation

Bach Knudsen, K. E., Lærke, H. N., Hedemann, M. S., Nielsen, T. S., Ingerslev, A. K., Gundelund Nielsen, D. S., Theil, P. K., Purup, S., Hald, S., Schioldan, A. G., et al. (2018) · Nutrients · doi:10.3390/nu10101499 · Cited by 572 · see citing works

Very long-chain <i>n</i> -3 fatty acids and human health: fact, fiction and the future

Calder, P. C. (2018) · Proceedings of the Nutrition Society · doi:10.1017/s0029665117003950 · Cited by 419 · see citing works

<i>n</i> -3 Fatty acids, inflammation and immunity: new mechanisms to explain old actions

Calder, P. C. (2013) · Proceedings of the Nutrition Society · doi:10.1017/s0029665113001031 · Cited by 364 · see citing works

Anti-Inflammatory Nutrients and Obesity-Associated Metabolic-Inflammation: State of the Art and Future Direction

Grosso, G., Laudisio, D., Frias-Toral, E., Barrea, L., Muscogiuri, G., Savastano, S., & Colao, A. (2022) · Nutrients · doi:10.3390/nu14061137 · Cited by 255 · see citing works

Monitoring immune modulation by nutrition in the general population: identifying and substantiating effects on human health

Albers, R., Bourdet-Sicard, R., Braun, D., Calder, P. C., Herz, U., Lambert, C., Lenoir-Wijnkoop, I., Méheust, A., Ouwehand, A., Phothirath, P., et al. (2013) · British Journal of Nutrition · doi:10.1017/s0007114513001505 · Cited by 150 · see citing works

Probiotic yogurt and acidified milk similarly reduce postprandial inflammation and both alter the gut microbiota of healthy, young men

Burton, K. J., Rosikiewicz, M., Pimentel, G., Bütikofer, U., von Ah, U., Voirol, M.-J., Croxatto, A., Aeby, S., Drai, J., McTernan, P. G., et al. (2017) · British Journal of Nutrition · doi:10.1017/s0007114517000885 · Cited by 121 · see citing works

The role of low-grade inflammation and metabolic flexibility in aging and nutritional modulation thereof: a systems biology approach

Calçada, D., Vianello, D., Giampieri, E., Sala, C., Castellani, G., de Graaf, A., Kremer, B., van Ommen, B., Feskens, E., Santoro, A., et al. (2014) · Mechanisms of Ageing and Development · doi:10.1016/j.mad.2014.01.004 · Cited by 97 · see citing works

Effect of Aerobic and Resistant Exercise Intervention on Inflammaging of Type 2 Diabetes Mellitus in Middle-Aged and Older Adults: A Systematic Review and Meta-Analysis

Xing, H., Lu, J., Yoong, S. Q., Tan, Y. Q., Kusuyama, J., & Wu, X. V. (2022) · Journal of the American Medical Directors Association · doi:10.1016/j.jamda.2022.01.055 · Cited by 53 · see citing works

The Role of Circulating Lycopene in Low-Grade Chronic Inflammation: A Systematic Review of the Literature

van Steenwijk, H. P., Bast, A., & de Boer, A. (2020) · Molecules · doi:10.3390/molecules25194378 · Cited by 41 · see citing works

The effects of acceptance and commitment therapy (ACT) intervention on inflammation and stress biomarkers: a randomized controlled trial

Järvelä-Reijonen, E., Puttonen, S., Karhunen, L., Sairanen, E., Laitinen, J., Kolehmainen, M., Pihlajamäki, J., Kujala, U. M., Korpela, R., Ermes, M., et al. (2020) · International Journal of Behavioral Medicine · doi:10.1007/s12529-020-09891-8 · Cited by 27 · see citing works

Enhanced Vitamin C Delivery: A Systematic Literature Review Assessing the Efficacy and Safety of Alternative Supplement Forms in Healthy Adults

Calder, P. C., Kreider, R. B., & McKay, D. L. (2025) · Nutrients · doi:10.3390/nu17020279 · Cited by 12 · see citing works

DETERMINING QUALITY REQUIREMENTS AT THE UNIVERSITIES TO IMPROVE THE QUALITY OF EDUCATION

Mustafa, N. H., Kelesbayev, D., & Alibekova, Z. D. (2018) · The Journal of Economic Research & Business Administration · doi:10.26577/be-2018-2-2141

Susquehanna Chorale Spring Concert "Roots and Wings"

Hawkins, D. (2017)

Genentech taps Affimed’s antibodies

Cross, R. (2018) · C&EN Global Enterprise · doi:10.1021/cen-09635-buscon15

KOMPLIKASI REGIONAL ANESTESI PADA PEDIATRIK

Sari, D. (2023) · Jurnal Komplikasi Anestesi · doi:10.22146/jka.v5i1.7322

Enxerto livre de arteria epigastrica inferior: avaliacao hemodinamica e angiografica pre e pos-operatoria

Dib, A., Puig, L. B., Salvadori, D., et al. (1988) · Arquivos Brasileiros de Cardiologia