The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups.
Open accessAbstract
Hepatitis C virus (HCV) is an important human pathogen that is associated with transfusion-related non-A, non-B hepatitis. Recently, HCV cDNA was cloned and the nucleotide sequence of approximately three-quarters of the virus genome was determined. A region of the predicted polyprotein sequence was found to share similarity with a nonstructural protein encoded by dengue virus, a member of the flavivirus family. We report here that HCV shares an even greater degree of protein sequence similarity with members of the pestivirus group (i.e., bovine viral diarrhea virus and hog cholera virus), which are thought to be distantly related to the flaviviruses. In addition, we find that HCV shares significant protein sequence similarity with the polyproteins encoded by members of the picornavirus-like and alphavirus-like plant virus supergroups. These data suggest that HCV may be evolutionarily related to both plant and animal viruses.
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Needleman, S. B., & Wunsch, C. D. (1970) · Journal of Molecular Biology · doi:10.1016/0022-2836(70)90057-4 · Cited by 11,288
Improved tools for biological sequence comparison.
Pearson, W. R., & Lipman, D. J. (1988) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.85.8.2444 · Cited by 11,227
Cited by
Identification and properties of the RNA-dependent RNA polymerase of hepatitis C virus.
Behrens, S. E., Tomei, L., & De Francesco, R. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00329.x · Cited by 698
Barba, G., Harper, F., Harada, T., Kohara, M., Goulinet, S., Matsuura, Y., Eder, G., Schaff, Z., Chapman, M. J., Miyamura, T., et al. (1997) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.94.4.1200 · Cited by 658
Crystal structure of the RNA-dependent RNA polymerase of hepatitis C virus
Bressanelli, S., Tomei, L., Roussel, A., Incitti, I., Vitale, R. L., Mathieu, M., De Francesco, R., & Rey, F. A. (1999) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.96.23.13034 · Cited by 586
Wang, C., Sarnow, P., & Siddiqui, A. (1993) · Journal of Virology · doi:10.1128/jvi.67.6.3338-3344.1993 · Cited by 441
Failla, C., Tomei, L., & De Francesco, R. (1994) · Journal of Virology · doi:10.1128/jvi.68.6.3753-3760.1994 · Cited by 411
Metadata
- Authors
- Miller, R. H., & Purcell, R. H.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-03
- Volume
- 87
- Issue
- 6
- Pages
- 2057-2061
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1971800756
- Cited by
- 637
- References
- 2
- FWCI
- 34.42
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. https://app.cochat.ai/papers/10.1073/pnas.87.6.2057
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- Miller, R. H., & Purcell, R. H. (1990). Hepatitis C virus shares amino acid sequence similarity with pestiviruses and flaviviruses as well as members of two plant virus supergroups. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.6.2057
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
