The DOI matches its Crossref record; 27 of the 27 references it cites were found in a registry or an index.
Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism
Open accessAbstract
The human hepatitis C virus (HCV) contains a long 5' noncoding region (5' NCR). Computer-assisted and biochemical analyses suggest that there is a complex secondary structure in this region that is comparable to the secondary structures that are found in picornaviruses (E.A. Brown, H. Zhang, L.-H. Ping, and S.M. Lemon, Nucleic Acids Res. 20:5041-5045, 1992). Previous in vitro studies suggest that the HCV 5' NCR plays an important role during translation (K. Tsukiyama-Kohara, N. Iizuka, M. Kohara, and A. Nomoto, J. Virol. 66:1476-1483, 1992). Dicistronic and monocistronic expression vectors, in vitro translation, RNA transfections, and deletion mutagenesis studies were utilized to demonstrate unambiguously that the HCV 5' NCR is involved in translational control. Our data strongly support the conclusion that an internal ribosome entry site exists within the 5' noncoding sequences proximal to the initiator AUG. Furthermore, our results suggest that the HCV genome is translated in a cap-independent manner and that the sequences immediately upstream of the initiator AUG are essential for internal ribosome entry site function during translation.
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Single-step method of RNA isolation by acid guanidinium thiocyanate-phenol-chloroform extraction
Chomczynski, P., & Sacchi, N. (1987) · Analytical Biochemistry · doi:10.1016/0003-2697(87)90021-2 · Cited by 46,426
Kozak, M. (1986) · Cell · doi:10.1016/0092-8674(86)90762-2 · Cited by 4,741
The scanning model for translation: an update.
Kozak, M. (1989) · The Journal of cell biology · doi:10.1083/jcb.108.2.229 · Cited by 3,486
Firefly luciferase gene: structure and expression in mammalian cells.
de Wet, J. R., Wood, K. V., DeLuca, M., Helinski, D. R., & Subramani, S. (1987) · Molecular and Cellular Biology · doi:10.1128/mcb.7.2.725 · Cited by 3,087
Pelletier, J., & Sonenberg, N. (1988) · Nature · doi:10.1038/334320a0 · Cited by 1,934
Genetic organization and diversity of the hepatitis C virus.
Choo, Q. L., Richman, K. H., Han, J. H., Berger, K., Lee, C., Dong, C., Gallegos, C., Coit, D., Medina-Selby, R., & Barr, P. J. (1991) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.88.6.2451 · Cited by 1,716
Kato, N., Hijikata, M., Ootsuyama, Y., Nakagawa, M., Ohkoshi, S., Sugimura, T., & Shimotohno, K. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.24.9524 · Cited by 1,191
Hepatitis C virus infection is associated with the development of hepatocellular carcinoma.
Saito, I., Miyamura, T., Ohbayashi, A., Harada, H., Katayama, T., Kikuchi, S., Watanabe, Y., Koi, S., Onji, M., & Ohta, Y. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.17.6547 · Cited by 1,089
A simple phase-extraction assay for chloramphenicol acyltransferase activity
Seed, B., & Sheen, J.-Y. (1988) · Gene · doi:10.1016/0378-1119(88)90403-9 · Cited by 966
Internal ribosome entry site within hepatitis C virus RNA
Tsukiyama-Kohara, K., Iizuka, N., Kohara, M., & Nomoto, A. (1992) · Journal of Virology · doi:10.1128/jvi.66.3.1476-1483.1992 · Cited by 925
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IRES Trans-Acting Factors, Key Actors of the Stress Response
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Kauder, S. E., & Racaniello, V. R. (2004) · Journal of Clinical Investigation · doi:10.1172/jci200421323 · Cited by 83
Upadhyay, A., Dixit, U., Manvar, D., Chaturvedi, N., & Pandey, V. N. (2013) · Molecular & Cellular Proteomics · doi:10.1074/mcp.m112.017020 · Cited by 36
Metadata
- Authors
- Wang, C., Sarnow, P., & Siddiqui, A.
- Venue
- Journal of Virology
- Publisher
- American Society for Microbiology
- Published
- 1993-06
- Volume
- 67
- Issue
- 6
- Pages
- 3338-3344
- ISSN
- 0022-538X (ISSN-L)
- 1098-5514
- OpenAlex
- W1836032532
- Cited by
- 441
- References
- 27
- FWCI
- 6.12
- Type
- journal article
- Language
- en
- Open access
- green
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- Wang, C., Sarnow, P., & Siddiqui, A. (1993). Translation of human hepatitis C virus RNA in cultured cells is mediated by an internal ribosome-binding mechanism. Journal of Virology. https://doi.org/10.1128/jvi.67.6.3338-3344.1993
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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