The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Recombinant human bone morphogenetic protein induces bone formation.
Open accessAbstract
We have purified and characterized active recombinant human bone morphogenetic protein (BMP) 2A. Implantation of the recombinant protein in rats showed that a single BMP can induce bone formation in vivo. A dose-response and time-course study using the rat ectopic bone formation assay revealed that implantation of 0.5-115 micrograms of partially purified recombinant human BMP-2A resulted in cartilage by day 7 and bone formation by day 14. The time at which bone formation occurred was dependent on the amount of BMP-2A implanted; at high doses bone formation could be observed at 5 days. The cartilage- and bone-inductive activity of the recombinant BMP-2A is histologically indistinguishable from that of bone extracts. Thus, recombinant BMP-2A has therapeutic potential to promote de novo bone formation in humans.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
Bradford, M. M. (1976) · Analytical Biochemistry · doi:10.1016/0003-2697(76)90527-3 · Cited by 255,302
Cleavage of Structural Proteins during the Assembly of the Head of Bacteriophage T4
LAEMMLI, U. K. (1970) · Nature · doi:10.1038/227680a0 · Cited by 249,961
Cited by
Synthetic biodegradable polymers as orthopedic devices
Middleton, J. C., & Tipton, A. J. (2000) · Biomaterials · doi:10.1016/s0142-9612(00)00101-0 · Cited by 2,741
Cell-laden hydrogels for osteochondral and cartilage tissue engineering
Yang, J., Zhang, Y. S., Yue, K., & Khademhosseini, A. (2017) · Acta Biomaterialia · doi:10.1016/j.actbio.2017.01.036 · Cited by 652
Safety Profile for the Clinical Use of Bone Morphogenetic Proteins in the Spine
Poynton, A. R., & Lane, J. M. (2002) · Spine · doi:10.1097/00007632-200208151-00010 · Cited by 403
Saltation and Stasis: a Model of Human Growth
Lampl, M., Veldhuis, J. D., & Johnson, M. L. (1992) · Science · doi:10.1126/science.1439787 · Cited by 387
New synthetic biodegradable polymers as BMP carriers for bone tissue engineering
Saito, N., & Takaoka, K. (2003) · Biomaterials · doi:10.1016/s0142-9612(03)00040-1 · Cited by 153
Metadata
- Authors
- Wang, E. A., Rosen, V, D'Alessandro, J. S., Bauduy, M., Cordes, P., Harada, T., Israel, D. I., Hewick, R. M., Kerns, K. M., & LaPan, P.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-03
- Volume
- 87
- Issue
- 6
- Pages
- 2220-2224
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2012333093
- Cited by
- 1,523
- References
- 2
- FWCI
- 14.05
- Type
- journal article
- Language
- en
- Open access
- green
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Recombinant human bone morphogenetic protein induces bone formation. https://app.cochat.ai/papers/10.1073/pnas.87.6.2220
- The paper
- Wang, E. A., Rosen, V, D'Alessandro, J. S., Bauduy, M., Cordes, P., Harada, T., Israel, D. I., Hewick, R. M., Kerns, K. M., & LaPan, P. (1990). Recombinant human bone morphogenetic protein induces bone formation. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.6.2220
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
