The DOI matches its Crossref record; 6 of the 6 references it cites were found in a registry or an index.
Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide.
Open accessAbstract
Incubation of human washed platelets with bovine aortic endothelial cells (ECs) treated with indomethacin resulted in an inhibition of thrombin-induced platelet aggregation that was dependent on the number of ECs added. Preincubation of ECs with Escherichia coli lipopolysaccharide (LPS; 0.5-2.0 micrograms/ml) for 1 min significantly enhanced their inhibitory activity. This effect was potentiated by superoxide dismutase (60 units/ml) and reversed by oxyhemoglobin (5-10 microM), indicating that the inhibition was due to the release of endothelium-derived relaxing factor (nitric oxide). When the ECs were pretreated with NG-monomethyl-L-arginine (30-300 microM) before LPS, the antiaggregatory activity was strongly reduced. The reduction of activity by NG-monomethyl-L-arginine was reversed by L-arginine (100 microM) but not by D-arginine (100 microM). Under similar conditions, LPS also enhanced the antiaggregatory activity of ECs grown on beads. The immediate enhancement by LPS of the release of endothelium-derived relaxing factor from endothelial cells may contribute to the rapid fall in blood pressure associated with endotoxin shock in vivo.
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Nitric oxide release accounts for the biological activity of endothelium-derived relaxing factor
Palmer, R. M. J., Ferrige, A. G., & Moncada, S. (1987) · Nature · doi:10.1038/327524a0 · Cited by 10,704
Macrophage cytotoxicity: role for L-arginine deiminase and imino nitrogen oxidation to nitrite
Hibbs, J. B., Taintor, R. R., & Vavrin, Z. (1987) · Science · doi:10.1126/science.2432665 · Cited by 1,527
Stuehr, D. J., & Marletta, M. A. (1985) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.82.22.7738 · Cited by 1,126
Rapoport, R. M., Draznin, M. B., & Murad, F. (1983) · Nature · doi:10.1038/306174a0 · Cited by 631
Stuehr, D. J., Gross, S. S., Sakuma, I., Levi, R., & Nathan, C. F. (1989) · The Journal of experimental medicine · doi:10.1084/jem.169.3.1011 · Cited by 457
L-Arginine is a precursor for nitrate biosynthesis in humans
Leaf, C. D., Wishnok, J. S., & Tannenbaum, S. R. (1989) · Biochemical and Biophysical Research Communications · doi:10.1016/0006-291x(89)92325-5 · Cited by 129
Cited by
Nitrogen oxide levels in patients after trauma and during sepsis
OCHOA, J. B., UDEKWU, A. O., BILLIAR, T. R., CURRAN, R. D., CERRA, F. B., SIMMONS, R. L., & PEITZMAN, A. B. (1991) · Annals of Surgery · doi:10.1097/00000658-199111000-00013 · Cited by 599
Modulation of Prostaglandin Biosynthesis by Nitric Oxide and Nitric Oxide Donors
Mollace, V., Muscoli, C., Masini, E., Cuzzocrea, S., & Salvemini, D. (2005) · Pharmacological Reviews · doi:10.1124/pr.57.2.1 · Cited by 357
Self-citationEffects of Nitric Oxide in Septic Shock
VINCENT, J.-L., ZHANG, H., SZABO, C., & PREISER, J.-C. (2000) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/ajrccm.161.6.9812004 · Cited by 351
Mechanisms of bacterial lipopolysaccharide-induced endothelial apoptosis
Bannerman, D. D., & Goldblum, S. E. (2003) · American Journal of Physiology-Lung Cellular and Molecular Physiology · doi:10.1152/ajplung.00338.2002 · Cited by 334
Immune cells: free radicals and antioxidants in sepsis
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Metadata
- Authors
- Salvemini, D., Korbut, R., Anggård, E., & Vane, J.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1990-04
- Volume
- 87
- Issue
- 7
- Pages
- 2593-2597
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2053289392
- Cited by
- 190
- References
- 6
- FWCI
- 10.73
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. https://app.cochat.ai/papers/10.1073/pnas.87.7.2593
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- Salvemini, D., Korbut, R., Anggård, E., & Vane, J. (1990). Immediate release of a nitric oxide-like factor from bovine aortic endothelial cells by Escherichia coli lipopolysaccharide. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.87.7.2593
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
