The DOI matches its Crossref record; 48 of the 48 references it cites were found in a registry or an index.
Effects of Nitric Oxide in Septic Shock
Abstract
Nitric oxide (NO) is believed to play a key role in the pathogenesis of septic shock, although many aspects of NO's involvement remain poorly defined. Recent years have seen advances in our understanding of the production and effects of NO, but much of the work has been done in animal models and may not be directly relevant to the clinical situation. Differences between species and models can account for many of the apparently conflicting results obtained. Nevertheless, NO-directed strategies have been developed and tested clinically. However, NO can have both beneficial and detrimental effects on many organ systems in sepsis and attempts to nonselectively block all its actions may therefore not yield positive results on outcome. Further exploration and precision of the role of NO and development of techniques to assess the NO balance in individual patients is necessary before further progress can be made in this field.
Overview
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Integrity signals
Registry
Cites
Statistics
Verification
Claims the paper makes
The claims and statistics of this paper haven’t been checked yet.
Run the check — free, no account needed. It reads the open-access text and checks the sources it cites.
Self-check
Percentages, sums and reported differences re-computed from the paper’s own numbers.
The self-check needs the paper’s full text.
Citations
Cites
De Caterina, R., Libby, P., Peng, H. B., Thannickal, V. J., Rajavashisth, T. B., Gimbrone, M. A., Shin, W. S., & Liao, J. K. (1995) · Journal of Clinical Investigation · doi:10.1172/jci118074 · Cited by 1,782
Altered immune responses in mice lacking inducible nitric oxide synthase
Wei, X.-Q., Charles, I. G., Smith, A., Ure, J., Feng, G.-J., Huang, F.-P., Xu, D., Mullers, W., Moncada, S., & Liew, F. Y. (1995) · Nature · doi:10.1038/375408a0 · Cited by 1,292
An L-arginine/nitric oxide pathway present in human platelets regulates aggregation.
Radomski, M. W., Palmer, R. M., & Moncada, S. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.13.5193 · Cited by 1,208
López, A., Lorente, J. A., Steingrub, J., Bakker, J., McLuckie, A., Willatts, S., Brockway, M., Anzueto, A., Holzapfel, L., Breen, D., et al. (2004) · Critical Care Medicine · doi:10.1097/01.ccm.0000105581.01815.c6 · Cited by 921
Nitric oxide protects against cellular damage and cytotoxicity from reactive oxygen species.
Wink, D. A., Hanbauer, I., Krishna, M. C., DeGraff, W., Gamson, J., & Mitchell, J. B. (1993) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.90.21.9813 · Cited by 767
Clancy, R. M., Leszczynska-Piziak, J., & Abramson, S. B. (1992) · Journal of Clinical Investigation · doi:10.1172/jci115929 · Cited by 686
Kilbourn, R. G., Gross, S. S., Jubran, A., Adams, J., Griffith, O. W., Levi, R., & Lodato, R. F. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.9.3629 · Cited by 650
Effects of a nitric oxide synthase inhibitor in humans with septic shock
Petros, A., Lamb, G., Leone, A., Moncada, S., Bennett, D., & Vallance, P. (1994) · Cardiovascular Research · doi:10.1093/cvr/28.1.34 · Cited by 509
Stimulation of the nitric oxide synthase pathway in human hepatocytes by cytokines and endotoxin
Nussler, A. K., Di Silvio, M., Billiar, T. R., Hoffman, R. A., Geller, D. A., Selby, R., Madariaga, J., & Simmons, R. L. (1992) · The Journal of Experimental Medicine · doi:10.1084/jem.176.1.261 · Cited by 420
Szabó, C., Cuzzocrea, S., Zingarelli, B., O'Connor, M., & Salzman, A. L. (1997) · Journal of Clinical Investigation · doi:10.1172/jci119585 · Cited by 354
Cited by
Cecconi, M., Evans, L., Levy, M., & Rhodes, A. (2018) · The Lancet · doi:10.1016/s0140-6736(18)30696-2 · Cited by 2,254
Keh, D., Boehnke, T., Weber-Cartens, S., Schulz, C., Ahlers, O., Bercker, S., Volk, H.-D., Doecke, W.-D., Falke, K. J., & Gerlach, H. (2003) · American Journal of Respiratory and Critical Care Medicine · doi:10.1164/rccm.200205-446oc · Cited by 600
The Neuropathology of Septic Shock
Sharshar, T., Annane, D., de la Gradmaison, G. L., Brouland, J. P., Hopkinson, N. S., & Gray, F. (2004) · Brain Pathology · doi:10.1111/j.1750-3639.2004.tb00494.x · Cited by 348
Immune cells: free radicals and antioxidants in sepsis
Victor, V. M., Rocha, M., & De la Fuente, M. (2004) · International Immunopharmacology · doi:10.1016/j.intimp.2004.01.020 · Cited by 310
Platelets in Sepsis: An Update on Experimental Models and Clinical Data
Assinger, A., Schrottmaier, W. C., Salzmann, M., & Rayes, J. (2019) · Frontiers in Immunology · doi:10.3389/fimmu.2019.01687 · Cited by 283
Metadata
- Authors
- VINCENT, J.-L., ZHANG, H., SZABO, C., & PREISER, J.-C.
- Venue
- American Journal of Respiratory and Critical Care Medicine
- Publisher
- Oxford University Press (OUP)
- Published
- 2000-06-01
- Volume
- 161
- Issue
- 6
- Pages
- 1781-1785
- ISSN
- 1073-449X (ISSN-L)
- 1535-4970
- OpenAlex
- W2036140137
- Cited by
- 351
- References
- 48
- FWCI
- 12.11
- Type
- journal article
- Language
- en
- Open access
- closed
About these checks
Registry, retraction, Cites and statistics results are computed, not judged, with one exception: a printed reference that no index lists is read once by a model before it counts as a citation error. Claims are extracted by a model and kept only when their quote appears verbatim in the text; each cited source is then checked, with a model’s help, for whether it says what the claim relies on. Those verdicts can be wrong — read the claim’s quote and the cited source before relying on one.
Statistics and arithmetic are recomputed, not judged.
Confidence bands are shown only for fields calibrated on our annotated test set. None is calibrated yet, so no band is shown.
What counts as a claim ›How we measure confidence ›How we check this ›
Are you an author, or do you see a problem with this page? Request a review
How to cite
Cite CoChat for the checks on this page, and the paper for its own findings.
- This page
- CoChat. (2026). Citation check: Effects of Nitric Oxide in Septic Shock. https://app.cochat.ai/papers/10.1164/ajrccm.161.6.9812004
- The paper
- VINCENT, J.-L., ZHANG, H., SZABO, C., & PREISER, J.-C. (2000). Effects of Nitric Oxide in Septic Shock. American Journal of Respiratory and Critical Care Medicine. https://doi.org/10.1164/ajrccm.161.6.9812004
Data sources
Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
