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Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants.
Open accessAbstract
Toward the goal of gene therapy, we have been attempting to establish model somatic cell systems with the potential of sustained expression of the foreign gene. We report here that long-term expression of foreign genes in mouse embryo fibroblast implants can be achieved if a housekeeping gene promoter is used to drive transcription. Specifically, we have shown that in implants containing a beta-galactosidase gene linked to either an immediate early promoter of cytomegalovirus or a dihydrofolate reductase (DHFR) gene promoter, only the DHFR promoter allows long-term expression. We propose that choice of the promoter manifests significant influence on the long-term expression of genes introduced in fibroblast implants by retroviral vectors.
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Cited by
In Vivo Gene Delivery and Stable Transduction of Nondividing Cells by a Lentiviral Vector
Naldini, L., Blömer, U., Gallay, P., Ory, D., Mulligan, R., Gage, F. H., Verma, I. M., & Trono, D. (1996) · Science · doi:10.1126/science.272.5259.263 · Cited by 4,903
Self-citationGene therapy - promises, problems and prospects
Verma, I. M., & Somia, N. (1997) · Nature · doi:10.1038/38410 · Cited by 1,681
Self-citationNaldini, L., Blömer, U., Gage, F. H., Trono, D., & Verma, I. M. (1996) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.93.21.11382 · Cited by 1,499
Self-citationChung, J. H., Whiteley, M., & Felsenfeld, G. (1993) · Cell · doi:10.1016/0092-8674(93)80052-g · Cited by 854
McWhirter, J. R., Galasso, D. L., & Wang, J. Y. (1993) · Molecular and Cellular Biology · doi:10.1128/mcb.13.12.7587 · Cited by 420
Metadata
- Authors
- Scharfmann, R., Axelrod, J. H., & Verma, I. M.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-06
- Volume
- 88
- Issue
- 11
- Pages
- 4626-4630
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1968960126
- Cited by
- 280
- References
- 0
- FWCI
- 15.51
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. https://app.cochat.ai/papers/10.1073/pnas.88.11.4626
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- Scharfmann, R., Axelrod, J. H., & Verma, I. M. (1991). Long-term in vivo expression of retrovirus-mediated gene transfer in mouse fibroblast implants. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.11.4626
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
