Cited by 217Cancer Cells and MetastasisMelanoma and MAPK PathwaysTGF-β signaling in diseases

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Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression

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Cornil, I, Theodorescu, D, Man, S, Herlyn, M, Jambrosic, J, Kerbel, R S·1991·Proceedings of the National Academy of Sciences

DOI 10.1073/pnas.88.14.6028PMC PMC52015

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Abstract

It is known from a variety of experimental systems that the ability of tumor cells to grow locally and metastasize can be affected by the presence of adjacent normal tissues and cells, particularly mesenchymally derived stromal cells such as fibroblasts. However, the comparative influence of such normal cell-tumor cell interactions on tumor behavior has not been thoroughly investigated from the perspective of different stages of tumor progression. To address this question we assessed the influence of normal dermal fibroblasts on the growth of human melanoma cells obtained from different stages of tumor progression. We found that the in vitro growth of most (4 out of 5) melanoma cell lines derived from early-stage radial growth phase or vertical growth phase metastatically incompetent primary lesions is repressed by coculture with normal dermal fibroblasts, suggesting that negative homeostatic growth controls are still operative on melanoma cells from early stages of disease. On the other hand, 9 out of 11 melanoma cell lines derived from advanced metastatically competent vertical growth phase primary lesions, or from distant metastases, were found to be consistently stimulated to grow in the presence of dermal fibroblasts. Evidence was obtained to show that this discriminatory fibroblastic influence is mediated by soluble inhibitory and stimulatory growth factor(s). Taken together, these results indicate that fibroblast-derived signals can have antithetical growth effects on metastatic versus metastatically incompetent tumor subpopulations. This resultant conversion in responsiveness to host tissue environmental factors may confer upon small numbers of metastatically competent cells a growth advantage, allowing them to escape local growth constraints both in the primary tumor site and at distant ectopic tissue sites.

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Tumors: Wounds That Do Not Heal
Flier, J. S., Underhill, L. H., & Dvorak, H. F. (1986) · New England Journal of Medicine · doi:10.1056/nejm198612253152606 · Cited by 4,391
Cell surface glycoprotein of reactive stromal fibroblasts as a potential antibody target in human epithelial cancers.
Garin‐Chesa, P., Old, L. J., & Rettig, W. J. (1990) · Proceedings of the National Academy of Sciences · doi:10.1073/pnas.87.18.7235 · Cited by 749
The Sequential Analysis of Cancer Development
Farber, E., & Cameron, R. (1980) · Advances in cancer research · doi:10.1016/s0065-230x(08)60658-2 · Cited by 594
Antitumor effects of interferon
Gresser, I., & Tovey, M. G. (1978) · Biochimica et Biophysica Acta (BBA) - Reviews on Cancer · doi:10.1016/0304-419x(78)90009-4 · Cited by 339
Stromal-epithelial interactions in adult organs
Cunha, G. R., Bigsby, R. M., Cooke, P. S., & Sugimura, Y. (1985) · Cell Differentiation · doi:10.1016/0045-6039(85)90481-6 · Cited by 309
Interleukins 1α and 6 and Tumor Necrosis Factor-α Are Paracrine Inhibitors of Human Melanocyte Proliferation and Melanogenesis
Swope, V. B., ABDEL‐MALEK, Z. A., Kassem, L. M., & Nordlund, J. J. (1991) · Journal of Investigative Dermatology · doi:10.1111/1523-1747.ep12460991 · Cited by 269
Specific growth response of ras-transformed embryo fibroblasts to tumour promoters
Dotto, G. P., Parada, L. F., & Weinberg, R. A. (1985) · Nature · doi:10.1038/318472a0 · Cited by 201
Growth Dominance of the Metastatic Cancer Cell: Cellular and Molecular Aspects
Kerbel, R. S. (1990) · Advances in cancer research · doi:10.1016/s0065-230x(08)60469-8 · Cited by 178
Cytokines in disease
Whicher, J. T., & Evans, S. (1990) · Clinical Chemistry · doi:10.1093/clinchem/36.7.1269 · Cited by 175
Metastatic but not primary melanoma cell lines grow in vitro independently of exogenous growth factors
Rodeck, U., Herlyn, M., Menssen, H. D., Furlanetto, R. W., & Koprowski, H. (1987) · International Journal of Cancer · doi:10.1002/ijc.2910400520 · Cited by 143

Show all 28 references

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Items 101–200 of 217

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Dong, L., Tian, X., Zhao, Y., Tu, H., Wong, A., & Yang, Y. (2022) · International Journal of Molecular Sciences · doi:10.3390/ijms232314775 · Cited by 36
Characterization of spontaneous metastasis in an aggressive breast carcinoma model using flow cytometry
Schmidt, C. M., Settle, S. L., Keene, J. L., Westlin, W., Nickols, G. A., & Griggs, D. W. (1999) · Clinical & Experimental Metastasis · doi:10.1023/a:1006719800907 · Cited by 36
Role of gangliosides in tumour progression: A molecular target for cancer therapy?
Fish, R. (1996) · Medical Hypotheses · doi:10.1016/s0306-9877(96)90014-6 · Cited by 33
Biphasic Effects of Thyrotropin on Invasion and Growth of Papillary and Follicular Thyroid Cancer in Vitro
Hoelting, T., Tezelman, S., SIPERSTEIN, A. E., Duh, Q., & Clark, O. H. (1995) · Thyroid · doi:10.1089/thy.1995.5.35 · Cited by 33
Phorbol ester phorbol-12-myristate-13-acetate promotes anchorage-independent growth and survival of melanomas through MEK-independent activation of ERK1/2
Jørgensen, K., Skrede, M. L., Cruciani, V., Mikalsen, S., Slipicevic, A., & Flørenes, V. A. (2005) · Biochemical and Biophysical Research Communications · doi:10.1016/j.bbrc.2005.01.143 · Cited by 36
Disruption of Prostaglandin E2 Signaling in Cancer-Associated Fibroblasts Limits Mammary Carcinoma Growth but Promotes Metastasis
Elwakeel, E., Brüggemann, M., Wagih, J., Lityagina, O., Elewa, M. A. F., Han, Y., Frömel, T., Popp, R., Nicolas, A. M., Schreiber, Y., et al. (2022) · Cancer Research · doi:10.1158/0008-5472.can-21-2116 · Cited by 32
The Extracellular Matrix Environment of Clear Cell Renal Cell Carcinoma Determines Cancer Associated Fibroblast Growth
Bond, K., Chiba, T., Wynne, K. J., Vary, C., Sims‐Lucas, S., Coburn, J. M., & Oxburgh, L. H. (2021) · Cancers · doi:10.3390/cancers13235873 · Cited by 38
Effects of fibroblast growth inhibitor on proliferation and metastasis of oral squamous cell carcinoma
Noguchi, N., Kawashiri, S., Tanaka, A., Kato, K., & Nakaya, H. (2003) · Oral Oncology · doi:10.1016/s1368-8375(02)00092-1 · Cited by 32
Reversion of tumor phenotype in surface transplants of skin SCC cells by scaffold-induced stroma modulation
Willhauck, M. J., Mirancea, N., Vosseler, S., Pavesio, A., Boukamp, P., Mueller, M. M., Fusenig, N. E., & Stark, H.-J. (2006) · Carcinogenesis · doi:10.1093/carcin/bgl188 · Cited by 33
Interleukin-1 regulates interleukin-6 secretion in human oral squamous cell carcinoma in vitro: possible influence of p53 but not human papillomavirus E6/E7.
Woods, K. V., Adler‐Storthz, K., Clayman, G. L., Francis, G. M., & Grimm, E. A. (1998) · PubMed · Cited by 32
The borderline: Basement membranes and the transition from premalignant to malignant neoplasia
Bosman, F. T. (1994) · Microscopy Research and Technique · doi:10.1002/jemt.1070280306 · Cited by 32
Cell membrane-derived nanovesicles as extracellular vesicle-mimetics in wound healing
Li, W., Zhang, H., Chen, L., Huang, C., Jiang, Z., Zhou, H., Zhu, X., Liu, X., Zheng, Z., Yu, Q., et al. (2025) · Materials Today Bio · doi:10.1016/j.mtbio.2025.101595 · Cited by 33
A microplate assay for selective measurement of growth of epithelial tumor cells in direct coculture with stromal cells.
Kawada, M., Yoshimoto, Y., Minamiguchi, K., Kumagai, H., Someno, T., Masuda, T., Ishizuka, M., & Ikeda, D. (2004) · PubMed · Cited by 31
Targeted deactivation of cancer-associated fibroblasts by β-catenin ablation suppresses melanoma growth
Zhou, L., YANG, K. Y., Wickett, R. R., Kadekaro, A. L., & Zhang, Y. (2016) · Tumor Biology · doi:10.1007/s13277-016-5293-6 · Cited by 29
The use of molecular genetic markers to demonstrate the effect of organ environment on clonal dominance in a human renal‐cell carcinoma grown in nude mice
Staroselsky, A. N., Radinsky, R., Fidler, I. J., Pathak, S., Chernajovsky, Y., & Frost, P. (1992) · International Journal of Cancer · doi:10.1002/ijc.2910510123 · Cited by 30
Variant sublines of early-stage human melanomas selected for tumorigenicity in nude mice express a multicytokine-resistant phenotype.
Kobayashi, H., Man, S., MacDougall, J. R., Graham, C. H., Lü, C., & Kerbel, R. S. (1994) · PubMed Central · Cited by 30
Expression of Leukemia Inhibitory Factor and Interleukin-11 by Human Melanoma Cell Lines: LIF, IL-6, and IL-11 Are Not Coregulated
PAGLIA, D., Oran, A. E., Lü, C., Kerbel, R. S., Sauder, D. N., & McKenzie, R. C. (1995) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1995.15.455 · Cited by 29
Myoepithelial-Specific CD44 Shedding Contributes to the Anti-invasive and Antiangiogenic Phenotype of Myoepithelial Cells
Alpaugh, M. L., Lee, M. C., Nguyen, M. T. N., Deato, M. D. E., Dishakjian, L., & Barsky, S. H. (2000) · Experimental Cell Research · doi:10.1006/excr.2000.5056 · Cited by 29
Relationship between stromal cells and tumor spread through air spaces in lung adenocarcinoma
Xie, Q., Chen, D., Liu, Y., Duan, S., Zhang, F., Zhang, Y., Feng, L., Chen, C., & Chen, Y. (2019) · Thoracic Cancer · doi:10.1111/1759-7714.12945 · Cited by 28
SEMA6A/RhoA/YAP axis mediates tumor-stroma interactions and prevents response to dual BRAF/MEK inhibition in BRAF-mutant melanoma
Loria, R., Laquintana, V., Scalera, S., Fraioli, R., Caprara, V., Falcone, I., Bazzichetto, C., Martile, M. D., Rosanò, L., Bufalo, D. D., et al. (2022) · Journal of Experimental & Clinical Cancer Research · doi:10.1186/s13046-022-02354-w · Cited by 26
S erum‐derived carcinoembryonic antigen ( CEA ) activates fibroblasts to induce a local re‐modeling of the extracellular matrix that favors the engraftment of CEA ‐expressing tumor cells
Abdul‐Wahid, A., Cydzik, M., Fischer, N. W., Prodeus, A., Shively, J. E., Martel, A. L., Alminawi, S., Ghorab, Z., Berinstein, N. L., & Gariépy, J. (2018) · International Journal of Cancer · doi:10.1002/ijc.31586 · Cited by 27
The tumor microenvironment: possible role of integrins and the extracellular matrix in tumor biological behavior of intratubular germ cell neoplasia and testicular seminomas.
Timmer, A., Oosterhuis, J. W., Koops, H. S., Sleijfer, D. T., Szabó, B. G., & Timens, W. (1994) · PubMed Central · Cited by 27
The Pigmentary System and Inflammation
Nordlund, J. J. (1992) · Pigment Cell Research · doi:10.1111/j.1600-0749.1992.tb00563.x · Cited by 27
Aberrations of growth factor control in metastatic follicular thyroid cancerin vitro
Hoelting, T., Zielke, A., SIPERSTEIN, A. E., Clark, O. H., & Duh, Q. Y. (1994) · Clinical & Experimental Metastasis · doi:10.1007/bf01753838 · Cited by 27
A model for initiated mouse skin: suppression of papilloma but not carcinoma formation by normal epidermal cells in grafts on athymic nude mice.
Strickland, J. E., Ueda, M., Hennings, H., & Yuspa, S. H. (1992) · PubMed · Cited by 27
Interleukin-6-resistant melanoma cells exhibit reduced activation of STAT3 and lack of inhibition of cyclin E-associated kinase activity.
Böhm, M., Schulte, U., Funk, J. O., Raghunath, M., Behrmann, I., Kortylewski, M., Heinrich, P. C., Kues, T., Luger, T., & Schwarz, T. (2001) · Journal of Investigative Dermatology · doi:10.1046/j.0022-202x.2001.01372.x · Cited by 24
Influence of fibroblasts on the invasion and migration of highly or weakly metastatic b16 melanoma cells
Saiki, I., Murataxd, J., Yoneda, J., Kobayashi, H., & Azuma, I. (1994) · International Journal of Cancer · doi:10.1002/ijc.2910560619 · Cited by 26
Suppression of T-lymphoma cell apoptosis by monoclonal antibodies raised against cell surface adhesion molecules.
Fujita, N., Kataoka, S., Naito, M., Heike, Y., Boku, N., Nakajima, M., & TSURUO, T. (1993) · PubMed · Cited by 26
Expression modes of interferon-α inducible genes in sensitive and resistant human melanoma cells stimulated with regular and pegylated interferon-α
Certa, U., Wilhelm-Seiler, M., Foser, S., Broger, C., & Neeb, M. (2003) · Gene · doi:10.1016/s0378-1119(03)00722-4 · Cited by 26
Reduction of TGF‐beta activity abrogates growth promoting tumor cell‐cell interactions in vivo
Theodorescu, D., Caltabiano, M. M., GREIG, R. G., Rieman, D. J., & Kerbel, R. S. (1991) · Journal of Cellular Physiology · doi:10.1002/jcp.1041480308 · Cited by 26
Epithelial–Mesenchymal Transition in Development and Diseases
Wu, Y., & Zhou, B. P. (2010) · Springer eBooks · doi:10.1007/978-1-4419-6615-5_9 · Cited by 25
Proliferating fibroblasts and HeLa cells co-cultured in vitro reciprocally influence growth patterns, protein expression, chromatin features and cell survival.
Delinassios, J. G., Angeli, F., Koumakis, G., Kumar, S., Kang, W.-H., Sica, G., Iacopino, F., Lama, G., Lamprecht, S. A., Sigal-Batikoff, I., et al. (2015) · PubMed · Cited by 24
Extracellular matrix in invasion and metastasis of oral squamous cell carcinoma
Kumar, K., & Hema, K. (2019) · Journal of Oral and Maxillofacial Pathology · doi:10.4103/jomfp.jomfp_97_19 · Cited by 25
A Framework of Major Tumor-Promoting Signal Transduction Pathways Implicated in Melanoma-Fibroblast Dialogue
Bellei, B., Migliano, E., & Picardo, M. (2020) · Cancers · doi:10.3390/cancers12113400 · Cited by 25
Three-dimensional multicellular cell culture for anti-melanoma drug screening: focus on tumor microenvironment
Saleh, N. A., Rode, M. P., Sierra, J. A., Silva, A. H., Miyake, J. A., Filippin-Monteiro, F. B., & Creczynski‐Pasa, T. B. (2020) · Cytotechnology · doi:10.1007/s10616-020-00440-5 · Cited by 26
Mass Spectrometry-Based Proteomic Characterization of Cutaneous Melanoma Ectosomes Reveals the Presence of Cancer-Related Molecules
Surman, M., Kędracka–Krok, S., Hoja-Łukowicz, D., Jankowska, U., Drożdż, A., Stępień, E. Ł., & Przybyło, M. (2020) · International Journal of Molecular Sciences · doi:10.3390/ijms21082934 · Cited by 24
Differential modulation of Bax/Bcl-2 ratio and onset of caspase-3/7 activation induced by derivatives of Justicidin B in human melanoma cells A375
Alqathama, A. A., Gibbons, S., & Prieto, J. M. (2017) · Oncotarget · doi:10.18632/oncotarget.21625 · Cited by 24
Systems-Level Modeling of Cancer-Fibroblast Interaction
Wadlow, R. C., Wittner, B. S., Finley, S. A., Bergquist, H., Upadhyay, R., Finn, S. P., Loda, M. F., Mahmood, U., & Ramaswamy, S. (2009) · PLoS ONE · doi:10.1371/journal.pone.0006888 · Cited by 23
Tumor cell motility and metastasis
Silletti, S., Paku, S., & Raz, A. (1997) · Pathology & Oncology Research · doi:10.1007/bf02899927 · Cited by 22
Spontaneous and induced differentiation of human melanoma cells
Valyi-Nagy, I. T., Shih, I., Györfi, T., Greenstein, D., Juhász, I., Herlyn, M., & Elder, D. E. (1993) · International Journal of Cancer · doi:10.1002/ijc.2910540125 · Cited by 23
Site-Specific Epithelial-Mesenchymal Interactions in Digestive Neuroendocrine Tumors
Dumortier, J., Ratineau, C., Scoazec, J., Pourreyron, C., Anderson, W., Jacquier, M., Blanc, M., Bernard, C., Bellaton, C., Remy, L., et al. (2000) · American Journal Of Pathology · doi:10.1016/s0002-9440(10)64771-2 · Cited by 22
Paracrine/autocrine growth mechanisms in tumor metastasis.
Gl, N. (1992) · PubMed · Cited by 22
Targeting the stromal fibroblasts: a novel approach to melanoma therapy
Smalley, K. S. M., Lioni, M., & Herlyn, M. (2005) · Expert Review of Anticancer Therapy · doi:10.1586/14737140.5.6.1069 · Cited by 21
IG20, a MADD splice variant, increases cell susceptibility to gamma-irradiation and induces soluble mediators that suppress tumor cell growth.
Efimova, E. V., Martinez, O., Lokshin, A. E., Arima, T., & Prabhakar, B. S. (2003) · PubMed · Cited by 19
Interleukin-1 Production in Tumor Cells of Human Melanoma Surgical Specimens
Tyler, D. S., Francis, G. M., Frederick, M. J., Tran, A., ORDÓÑZ, N. G., Smith, J. L., Eton, O. E., Ross, M. I., & Grimm, E. A. (1995) · Journal of Interferon & Cytokine Research · doi:10.1089/jir.1995.15.331 · Cited by 19
Growth Regulation in Normal and Malignant Melanocytes
Halaban, R. (1993) · Recent results in cancer research/Recent Results in Cancer Research · doi:10.1007/978-3-642-84881-0_10 · Cited by 19
High-resolution analyses of two different classes of tumor cells in situ tagged with alternative histochemical marker genes.
Lin, W., Pretlow, T. P., Pretlow, T. G., & Culp, L. A. (1992) · PubMed Central · Cited by 19
Fibroblast subpopulations as accelerators of tumor progression: The role of migration stimulating factor
Schor, S. L. (1995) · Proceedings of the Fourth International Symposium on Polarization Phenomena in Nuclear Reactions · doi:10.1007/978-3-0348-9070-0_14 · Cited by 18
Cancer-Associated Fibroblasts in a Human HEp-2 Established Laryngeal Xenografted Tumor Are Not Derived from Cancer Cells through Epithelial-Mesenchymal Transition, Phenotypically Activated but Karyotypically Normal
Wang, M., Wu, C., Pan, J.-Y., Zheng, W.-W., Cao, X., & Fan, G. (2015) · PLoS ONE · doi:10.1371/journal.pone.0117405 · Cited by 17
Analysis of a mathematical model of periodically pulsed chemotherapy treatment
Samanta, G. P., Aíza, R. G., & Sharma, S. (2015) · International Journal of Dynamics and Control · doi:10.1007/s40435-015-0204-z · Cited by 16
IL-2 regulates the expression of the tumor suppressor IL-24 in melanoma cells
Jen, E. Y., Poindexter, N. J., Farnsworth, E., & Grimm, E. A. (2011) · Melanoma Research · doi:10.1097/cmr.0b013e32834d2506 · Cited by 16
Myoepithelial-Specific CD44 Shedding Is Mediated by a Putative Chymotrypsin-like Sheddase
Lee, M. C., Alpaugh, M. L., Nguyen, M. T. N., Deato, M. D. E., Dishakjian, L., & Barsky, S. H. (2000) · Biochemical and Biophysical Research Communications · doi:10.1006/bbrc.2000.3918 · Cited by 16
Generation of 3D melanoma models using an assembloid-based approach
Rodrigues, D. B., Moreira, H. R., Jarnalo, M., Horta, R., Marques, A. P., Reis, R. L., & Pirraco, R. P. (2024) · Acta Biomaterialia · doi:10.1016/j.actbio.2024.02.023 · Cited by 14
Distinctive Responsiveness to Stromal Signaling Accompanies Histologic Grade Programming of Cancer Cells
Luciani, M. G., Seok, J., Sayeed, A., Champion, S., Goodson, W. H., Jeffrey, S. S., Xiao, W., Mindrinos, M. N., Davis, R. W., & Dairkee, S. H. (2011) · PLoS ONE · doi:10.1371/journal.pone.0020016 · Cited by 14
Fetal-like fibroblasts: Their production of migration-stimulating factor and role in tumor progression
Schor, S. L., Grey, A. M., Ellis, I., Schor, A. M., Howell, A., Sloan, P., & Murphy, R. (1994) · Cancer treatment and research · doi:10.1007/978-1-4615-2592-9_15 · Cited by 14
Human skin fibroblasts induce anchorage‐independent growth of HPV‐16‐DNA‐immortalized cervical epithelial cells
Zheng, J., & Vaheri, A. I. (1995) · International Journal of Cancer · doi:10.1002/ijc.2910610512 · Cited by 14
Stromal Reaction to Invasive Cancer: The Cellular Origin of the Myofibroblast and Implications for Tumor Development
Rønnov‐Jessen, L. (1996) · The Breast Journal · doi:10.1111/j.1524-4741.1996.tb00117.x · Cited by 14
C16:0 ceramide effect on melanoma malignant behavior and glycolysis depends on its intracellular or exogenous location.
Liu, R., Cao, K., Tang, Y., Liu, J., Li, J., Chen, J., Wang, S., Chen, Z., & Zhou, J. (2020) · PubMed Central · Cited by 13
Myofibroblast androgen receptor expression determines cell survival in co-cultures of myofibroblasts and prostate cancer cells in vitro
Palethorpe, H. M., Leach, D. A., Need, E. F., Drew, P. A., & Smith, E. (2018) · Oncotarget · doi:10.18632/oncotarget.24913 · Cited by 12
Periodic fluctuations in proliferation of SV-40 transformed human skin fibroblast lines with prolonged lifespan
Wolfrom, C. M., Raynaud, N., Maigné, J., Papathanassiou, S., Conti, M., Kadhom, N., Hecquet, B., Lévi, F., Gautier, M., & Deschatrette, J. (1994) · Cell Biology and Toxicology · doi:10.1007/bf00756764 · Cited by 12
Intestinal-type fibroblasts selectively influence proliferation rate and peptide synthesis in the murine entero-endocrine cell line STC-1
Ratineau, C., Plateroti, M., Dumortier, J., Blanc, M., Kédinger, M., Chayvialle, J. A., & Roche, C. (1997) · Differentiation · doi:10.1046/j.1432-0436.1997.6230139.x · Cited by 12
The Role of Angiogenesis in Tumor Progression and Metastasis
Rak, J. W., Hegmann, E. J., & Kerbel, R. S. (1993) · Advances in molecular and cell biology · doi:10.1016/s1569-2558(08)60241-6 · Cited by 12
Myxoid stroma is associated with postoperative relapse in patients with stage II colon cancer
Okuyama, T., Sameshima, S., Takeshita, E., Mitsui, T., Noro, T., Ono, Y., Noie, T., Ban, S., & Oya, M. (2020) · BMC Cancer · doi:10.1186/s12885-020-07335-w · Cited by 11
Similarities and Differences in the Protein Composition of Cutaneous Melanoma Cells and Their Exosomes Identified by Mass Spectrometry
Surman, M., Jankowska, U., Wilczak, M., & Przybyło, M. (2023) · Cancers · doi:10.3390/cancers15041097 · Cited by 10
Insights into Melanoma Fibroblast Populations and Therapeutic Strategy Perspectives: Friends or Foes?
Avagliano, A., & Arcucci, A. (2022) · Current Medicinal Chemistry · doi:10.2174/0929867329666220620124138 · Cited by 10
α5 and α2 Integrin Gene Transfers Mimic the PDGF-B–Induced Transformed Phenotype of Fibroblasts in Human Skin
Nesbit, M., Schaider, H., Berking, C., Shih, D.-T., Hsu, M., McBrian, M., Crombleholme, T. M., Elenitsas, R., Buck, C. A., & Herlyn, M. (2001) · Laboratory Investigation · doi:10.1038/labinvest.3780340 · Cited by 10
Melanocyte Mediated Paracrine Induction of Extracellular Matrix Degrading Proteases in Squamous Cell Carcinoma Cells
Borchers, A. H., Sanders, L. A., Powell, M. B., & Bowden, G. T. (1997) · Experimental Cell Research · doi:10.1006/excr.1996.3449 · Cited by 10
The metastatic phenotype—prognostic implications
Lindblom, A., & Linder, S. T. (1996) · Critical Reviews in Oncology/Hematology · doi:10.1016/1040-8428(96)00213-2 · Cited by 10
Increased activity of cathepsin B in fibroblasts isolated from primary melanoma in comparison to fibroblasts from normal skin
Ulmer, A., Körber, V., Schmid, H., & Fierlbeck, G. (1998) · Experimental Dermatology · doi:10.1111/j.1600-0625.1998.tb00297.x · Cited by 10
Hormonal and Stromal Regulation of Normal and Neoplastic Prostatic Growth
Ricke, W. A., Wang, Y. Z., Kurita, T., Hayward, S. W., & Cunha, G. R. (2005) · Springer eBooks · doi:10.1007/3-540-27671-8_8 · Cited by 10
Discovery of Endothelium and Mesenchymal Properties of Primo Vessels in the Mesentery
An, P., Zhendong, S., Jingxing, D., Yaling, L., Bae, K.-H., Shiyun, T., Hesheng, L., Soh, K., Ryu, Y. H., & Kim, S. (2013) · Evidence-based Complementary and Alternative Medicine · doi:10.1155/2013/205951 · Cited by 8
Osteopontin Mediates Dense Culture‐Induced Proliferation and Adhesion of Prostate Tumour Cells: Role of Protein Kinase C, p38 Mitogen‐Activated Protein Kinase and Calcium
Zhou, H., Lü, N., Chen, Z., Song, Q., Yu, H., & Li, X. (2008) · Basic & Clinical Pharmacology & Toxicology · doi:10.1111/j.1742-7843.2008.00348.x · Cited by 8
Interleukin-2 and cancer:
Alileche, A. (2003) · Medical Hypotheses · doi:10.1016/s0306-9877(02)00359-6 · Cited by 8
The pathogenesis of cancer metastasis: relevance to therapy
Kim, S.-J., Baker, C. H., Kitadai, Y., Nakamura, T., Kuwai, T., Sasaki, T., Langley, R. R., & Fidler, I. J. (2009) · Springer eBooks · doi:10.1007/978-90-481-2289-9_2 · Cited by 9
Tissue Models to Study Tumor-Stroma Interactions
Fusenig, N. E., Skobe, M., Vosseler, S., Hansen, M., Lederle, W., Airola, K., Tomakidi, P., Stark, H.-J., Steinbauer, H., Mirancea, N., et al. (2006) · Kluwer Academic Publishers eBooks · doi:10.1007/1-4020-2008-2_11 · Cited by 8
The Proangiogenic Effects of Melanoma-Derived Ectosomes Are Mediated by αvβ5 Integrin Rather than αvβ3 Integrin
Surman, M., Wilczak, M., Bzowska, M., Tylko, G., & Przybyło, M. (2024) · Cells · doi:10.3390/cells13161336 · Cited by 7
Modulation of clonogenicity, growth, and radiosensitivity of three human epidermoid tumor cell lines by a fibroblastic environment
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Authors: Cornil, I., Theodorescu, D., Man, S., Herlyn, M., Jambrosic, J., & Kerbel, R. S.
Affiliations: Mount Sinai Hospital (CA)
ORCID: Theodorescu, D
Venue: Proceedings of the National Academy of Sciences
Publisher: National Academy of Sciences
Published: 1991-07-15
Volume: 88
Issue: 14
Pages: 6028-6032
ISSN: 0027-8424 (ISSN-L)
1091-6490
DOI: 10.1073/pnas.88.14.6028
PMC: PMC52015
OpenAlex: W2015028428
Cited by: 217
References: 28
Citations by year: 2026: 1 · 2025: 2 · 2024: 2 · 2023: 2 · 2022: 6 · 2021: 3 · 2020: 9 · 2019: 4 · 2018: 7 · 2017: 7 · 2016: 7 · 2015: 8 · 2014: 2 · 2013: 5 · 2012: 5
FWCI: 6.47
Type: journal article
Language: en
Open access: green
www.ncbi.nlm.nih.gov
Locations: Proceedings of the National Academy of Sciences (publishedVersion)
PubMed Central (publishedVersion)
PubMed (publishedVersion)
HAL (submittedVersion)
Funders: National Institutes of Health (5r01ca044877-08)
U.S. Public Health Service (R0I-42331)
National Cancer Institute (CA-25874, P01CA025874, CA 44877)
Topics: Health Sciences › Medicine › Oncology › Cancer Cells and Metastasis
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › Melanoma and MAPK Pathways
Life Sciences › Biochemistry, Genetics and Molecular Biology › Molecular Biology › TGF-β signaling in diseases
Keywords: melanoma, dermal fibroblasts, tumor microenvironment, tumor progression, tumor growth, metastasis, radial growth phase, vertical growth phase, tumor stroma, soluble growth factors, metastatic competence
MeSH terms: Adipose Tissue, Animals, Cattle, Cell Communication, Cell Division, Cells, Cultured, DNA Replication, Endothelium, Vascular, Fibroblasts, Humans, Infant, Newborn, Male, Melanoma, Skin, Skin Physiological Phenomena

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Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression

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