Theodorescu, Dan

Detection of Circulating Tumor DNA in Early- and Late-Stage Human Malignancies

Bettegowda, C., Sausen, M., Leary, R. J., Kinde, I., Wang, Y., Agrawal, N., Bartlett, B. R., Wang, H., Luber, B., Alani, R. M., et al. (2014) · Science Translational Medicine

Cancer Genomics and DiagnosticsPrenatal Screening and Diagnostics

Cited by 5,067

TERT promoter mutations occur frequently in gliomas and a subset of tumors derived from cells with low rates of self-renewal

Killela, P. J., Reitman, Z. J., Jiao, Y., Bettegowda, C., Agrawal, N., Diaz, L. A., Friedman, A. H., Friedman, H., Gallia, G. L., Giovanella, B. C., et al. (2013) · Proceedings of the National Academy of Sciences

Telomeres, Telomerase, and SenescenceCancer-related molecular mechanisms research

Cited by 1,368

TERT promoter mutations and telomerase reactivation in urothelial cancer

Borah, S., Xi, L., Zaug, A. J., Powell, N. M., Dancik, G. M., Cohen, S. B., Costello, J. C., Theodorescu, D., & Cech, T. R. (2015) · Science

Telomeres, Telomerase, and SenescenceBladder and Urothelial Cancer Treatments

Cited by 292

Fibroblast cell interactions with human melanoma cells affect tumor cell growth as a function of tumor progression

Cornil, I., Theodorescu, D., Man, S., Herlyn, M., Jambrosic, J., & Kerbel, R. S. (1991) · Proceedings of the National Academy of Sciences

Cancer Cells and MetastasisMelanoma and MAPK Pathways

Cited by 217

Discovery and characterization of small molecules that target the GTPase Ral

Yan, C., Liu, D., Li, L., Wempe, M. F., Guin, S., Khanna, M., Meier, J., Hoffman, B., Owens, C., Wysoczynski, C. L., et al. (2014) · Nature

Protein Kinase Regulation and GTPase SignalingComputational Drug Discovery Methods

Cited by 150

RalA and RalB: Antagonistic Relatives in Cancer Cell Migration

Oxford, G., Owens, C. R., Titus, B. J., Foreman, T. L., Herlevsen, M. C., Smith, S. C., & Theodorescu, D. (2005) · Cancer Research

Protein Kinase Regulation and GTPase SignalingMechanisms of cancer metastasis

Cited by 139

CD24 Is an Effector of HIF-1–Driven Primary Tumor Growth and Metastasis

Thomas, S., Harding, M. A., Smith, S. C., Overdevest, J. B., Nitz, M. D., Frierson, H. F., Tomlins, S. A., Kristiansen, G., & Theodorescu, D. (2012) · Cancer Research

Cancer, Hypoxia, and MetabolismCancer Cells and Metastasis

Cited by 128

RAL GTPases: Biology and Potential as Therapeutic Targets in Cancer

Yan, C., & Theodorescu, D. (2018) · Pharmacological Reviews

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 119

Src and caveolin-1 reciprocally regulate metastasis via a common downstream signaling pathway in bladder cancer

Thomas, S., Overdevest, J. B., Nitz, M. D., Williams, P. D., Owens, C. R., Sanchez-Carbayo, M., Frierson, H. F., Schwartz, M. A., & Theodorescu, D. (2011) · Cancer Research

Caveolin-1 and cellular processesBladder and Urothelial Cancer Treatments

Cited by 92

Review Article: The Role of Ras Superfamily Proteins in Bladder Cancer Progression

OXFORD, G., & THEODORESCU, D. (2003) · Journal of Urology

Protein Kinase Regulation and GTPase SignalingBladder and Urothelial Cancer Treatments

Cited by 86

RalBP1 is necessary for metastasis of human cancer cell lines

Wu, Z., Owens, C., Chandra, N., Popovic, K., Conaway, M., & Theodorescu, D. (2010) · Neoplasia

Protein Kinase Regulation and GTPase SignalingCellular transport and secretion

Cited by 70

RalA controls glucose homeostasis by regulating glucose uptake in brown fat

Skorobogatko, Y., Dragan, M., Cordon, C., Reilly, S. M., Hung, C.-W., Xia, W., Zhao, P., Wallace, M., Lackey, D. E., Chen, X.-W., et al. (2018) · Proceedings of the National Academy of Sciences

Adipose Tissue and MetabolismMetabolism, Diabetes, and Cancer

Cited by 52

Concurrent loss of the Y chromosome in cancer and T cells impacts outcome

Chen, X., Shen, Y., Choi, S., Abdel-Hafiz, H. A., Basu, M., Hoelzen, L., Tufano, M., Kailasam Mani, S. K., Ranjpour, M., Zhu, J., et al. (2025) · Nature

Genetic and Clinical Aspects of Sex Determination and Chromosomal AbnormalitiesCancer Immunotherapy and Biomarkers

Cited by 50

Determinants of long-term quality of life and voiding function of patients treated with radical prostatectomy or permanent brachytherapy for prostate cancer

Bradley, E. B., Bissonette, E. A., & Theodorescu, D. (2004) · BJU International

Prostate Cancer Diagnosis and TreatmentUrinary Bladder and Prostate Research

Cited by 46

CD24 targeting with NK‐CAR immunotherapy in testis, prostate, renal and (luminal‐type) bladder cancer and identification of direct CD24 interaction partners

Söhngen, C., Thomas, D. J., Skowron, M. A., Bremmer, F., Eckstein, M., Stefanski, A., Driessen, M. D., Wakileh, G. A., Stühler, K., Altevogt, P., et al. (2023) · The FEBS Journal

Immune Cell Function and InteractionCAR-T cell therapy research

Cited by 19