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Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo.
Open accessAbstract
The lectin homing receptor LECAM-1 (LAM-1, Leu8) and the beta 2 integrins, particularly Mac-1 (CD11b/CD18), participate in leukocyte-endothelial cell interactions in inflammation. LECAM-1 is rapidly shed while Mac-1 expression is dramatically increased upon neutrophil activation, suggesting functionally distinct roles for these molecules. Using intravital video microscopy, we have compared the effect of antibodies against LECAM-1 and CD18 on leukocyte interactions with rabbit mesenteric venules. Anti-LECAM-1 monoclonal antibody and its Fab fragments inhibited initial reversible leukocyte rolling along the vascular wall. Anti-CD18 monoclonal antibody had no effect on rolling but prevented subsequent firm attachment of leukocytes to venular endothelium. These results support a two-step model of leukocyte-endothelial cell interactions: reversible rolling mediated in part by LECAM-1 facilitates leukocyte recruitment by the local microenvironment and precedes activation-dependent firm attachment involving beta 2 integrins.
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Citations
Cited by
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Cerebral Vasospasm after Subarachnoid Hemorrhage: Putative Role of Inflammation
Dumont, A. S., Dumont, R. J., Chow, M. M., Lin, C.-L., Calisaneller, T., Ley, K. F., Kassell, N. F., & Lee, K. S. (2003) · Neurosurgery · doi:10.1227/01.neu.0000068863.37133.9e · Cited by 441
Metadata
- Authors
- von Andrian, U. H., Chambers, J. D., McEvoy, L. M., Bargatze, R. F., Arfors, K. E., & Butcher, E. C.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-09
- Volume
- 88
- Issue
- 17
- Pages
- 7538-7542
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W2107748719
- Cited by
- 953
- References
- 0
- FWCI
- 20.03
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. https://app.cochat.ai/papers/10.1073/pnas.88.17.7538
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- von Andrian, U. H., Chambers, J. D., McEvoy, L. M., Bargatze, R. F., Arfors, K. E., & Butcher, E. C. (1991). Two-step model of leukocyte-endothelial cell interaction in inflammation: distinct roles for LECAM-1 and the leukocyte beta 2 integrins in vivo. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.17.7538
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
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