The DOI matches its Crossref record; 2 of the 2 references it cites were found in a registry or an index.
Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF.
Open accessAbstract
The different isoforms of PDGF bind with different affinities to two different receptor types. Previously, these receptors have been demonstrated mainly on mesenchymal and glial cells. We show here that PDGF beta-type receptors are present also on rat brain neurons in vivo as well as in vitro. Immunohistochemical analysis of a sequentially sectioned brain of a newborn rat revealed the presence of PDGF beta receptors in neurons throughout the central nervous system. These beta-receptor-bearing cells were shown to contain neurofilaments by double immunofluorescence staining. Furthermore, the PDGF-BB isoform bound to cells in a neuron-enriched culture from newborn rat brains and induced c-Fos protein in these cells. Continuous PDGF-BB treatment of primary rat brain cell cultures resulted in outgrowth of neurites and prolonged survival. These results indicate a neurotrophic effect of PDGF-BB.
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Cites
Hohn, A., Leibrock, J., Bailey, K., & Barde, Y.-A. (1990) · Nature · doi:10.1038/344339a0 · Cited by 1,145
Noble, M., Murray, K., Stroobant, P., Waterfield, M. D., & Riddle, P. (1988) · Nature · doi:10.1038/333560a0 · Cited by 830
Cited by
The cellular and molecular basis of peripheral nerve regeneration
Fu, S. Y., & Gordon, T. (1997) · Molecular Neurobiology · doi:10.1007/bf02740621 · Cited by 1,202
Sondell, M., Lundborg, G., & Kanje, M. (1999) · The Journal of Neuroscience · doi:10.1523/jneurosci.19-14-05731.1999 · Cited by 750
“However, other angiogenic factors, including basic fibroblast growth factor (bFGF) and platelet-derived growth factor (PDGF), have been shown to be neurotrophic or exert growthpromoting activity (Rydel and Greene, 1987; Davis and Stroobant, 1990; Smits et al., 1991; Fujimoto et al., 1997).”
BackgroundTyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors
Brückner, K., Pasquale, E. B., & Klein, R. (1997) · Science · doi:10.1126/science.275.5306.1640 · Cited by 386
Sondell, M., Sundler, F., & Kanje, M. (2000) · European Journal of Neuroscience · doi:10.1046/j.0953-816x.2000.01326.x · Cited by 370
Winkler, E. A., Bell, R. D., & Zlokovic, B. V. (2010) · Molecular Neurodegeneration · doi:10.1186/1750-1326-5-32 · Cited by 346
Metadata
- Authors
- Smits, A., Kato, M., Westermark, B., Nistér, M., Heldin, C. H., & Funa, K.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-09-15
- Volume
- 88
- Issue
- 18
- Pages
- 8159-8163
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1978271705
- Cited by
- 220
- References
- 2
- FWCI
- 5.19
- Type
- journal article
- Language
- en
- Open access
- green
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- CoChat. (2026). Citation check: Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF. https://app.cochat.ai/papers/10.1073/pnas.88.18.8159
- The paper
- Smits, A., Kato, M., Westermark, B., Nistér, M., Heldin, C. H., & Funa, K. (1991). Neurotrophic activity of platelet-derived growth factor (PDGF): Rat neuronal cells possess functional PDGF beta-type receptors and respond to PDGF. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.18.8159
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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
