The DOI matches its Crossref record; 23 of the 23 references it cites were found in a registry or an index.
Tyrosine Phosphorylation of Transmembrane Ligands for Eph Receptors
Abstract
Axonal pathfinding in the nervous system is mediated in part by cell-to-cell signaling events involving members of the Eph receptor tyrosine kinase (RTK) family and their membrane-bound ligands. Genetic evidence suggests that transmembrane ligands may transduce signals in the developing embryo. The cytoplasmic domain of the transmembrane ligand Lerk2 became phosphorylated on tyrosine residues after contact with the Nuk/Cek5 receptor ectodomain, which suggests that Lerk2 has receptorlike intrinsic signaling potential. Moreover, Lerk2 is an in vivo substrate for the platelet-derived growth factor receptor, which suggests crosstalk between Lerk2 signaling and signaling cascades activated by tyrosine kinases. It is proposed that transmembrane ligands of Eph receptors act not only as conventional RTK ligands but also as receptorlike signaling molecules.
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Cites
Protein modules and signalling networks
Pawson, T. (1995) · Nature · doi:10.1038/373573a0 · Cited by 2,420
Stahl, N., Farruggella, T. J., Boulton, T. G., Zhong, Z., Darnell, J. E., & Yancopoulos, G. D. (1995) · Science · doi:10.1126/science.7871433 · Cited by 979
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Gale, N. W., Holland, S. J., Valenzuela, D. M., Flenniken, A., Pan, L., Ryan, T. E., Henkemeyer, M., Strebhardt, K., Hirai, H., Wilkinson, D. G., et al. (1996) · Neuron · doi:10.1016/s0896-6273(00)80276-7 · Cited by 839
Davis, S., Gale, N. W., Aldrich, T. H., Maisonpierre, P. C., Lhotak, V., Pawson, T., Goldfarb, M., & Yancopoulos, G. D. (1994) · Science · doi:10.1126/science.7973638 · Cited by 710
Nuk Controls Pathfinding of Commissural Axons in the Mammalian Central Nervous System
Henkemeyer, M., Orioli, D., Henderson, J. T., Saxton, T. M., Roder, J., Pawson, T., & Klein, R. (1996) · Cell · doi:10.1016/s0092-8674(00)80075-6 · Cited by 534
Self-citationBidirectional signalling through the EPH-family receptor Nuk and its transmembrane ligands
Holland, S. J., Gale, N. W., Mbamalu, G., Yancopoulos, G. D., Henkemeyer, M., & Pawson, T. (1996) · Nature · doi:10.1038/383722a0 · Cited by 516
Nakamoto, M., Cheng, H.-J., Friedman, G. C., McLaughlin, T., Hansen, M. J., Yoon, C. H., O'Leary, D. D. M., & Flanagan, J. G. (1996) · Cell · doi:10.1016/s0092-8674(00)80150-6 · Cited by 415
Recognition and specificity in protein tyrosine kinase-mediated signalling
Songyang, Z., & Cantley, L. C. (1995) · Trends in Biochemical Sciences · doi:10.1016/s0968-0004(00)89103-3 · Cited by 370
Sek4 and Nuk receptors cooperate in guidance of commissural axons and in palate formation.
Orioli, D., Henkemeyer, M., Lemke, G., Klein, R., & Pawson, T. (1996) · The EMBO Journal · doi:10.1002/j.1460-2075.1996.tb00992.x · Cited by 333
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Cited by
THE EPHRINS AND EPH RECEPTORS IN NEURAL DEVELOPMENT
Flanagan, J. G., & Vanderhaeghen, P. (1998) · Annual Review of Neuroscience · doi:10.1146/annurev.neuro.21.1.309 · Cited by 1,080
Eph receptor signalling casts a wide net on cell behaviour
Pasquale, E. B. (2005) · Nature Reviews Molecular Cell Biology · doi:10.1038/nrm1662 · Cited by 1,017
Self-citationNeurexin mediates the assembly of presynaptic terminals
Dean, C., Scholl, F. G., Choih, J., DeMaria, S., Berger, J., Isacoff, E., & Scheiffele, P. (2003) · Nature Neuroscience · doi:10.1038/nn1074 · Cited by 617
Conover, J. C., Doetsch, F., Garcia-Verdugo, J.-M., Gale, N. W., Yancopoulos, G. D., & Alvarez-Buylla, A. (2000) · Nature Neuroscience · doi:10.1038/80606 · Cited by 481
PDZ Proteins Bind, Cluster, and Synaptically Colocalize with Eph Receptors and Their Ephrin Ligands
Torres, R., Firestein, B. L., Dong, H., Staudinger, J., Olson, E. N., Huganir, R. L., Bredt, D. S., Gale, N. W., & Yancopoulos, G. D. (1998) · Neuron · doi:10.1016/s0896-6273(00)80663-7 · Cited by 451
Metadata
- Authors
- Brückner, K., Pasquale, E. B., & Klein, R.
- Venue
- Science
- Published
- 1997-03-14
- Volume
- 275
- Issue
- 5306
- Pages
- 1640-1643
- ISSN
- 0036-8075 (ISSN-L)
- 1095-9203
- OpenAlex
- W2042482088
- Cited by
- 386
- References
- 23
- FWCI
- 12.79
- Type
- journal article
- Language
- en
- Open access
- closed
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Bibliographic data: Semantic Scholar, OpenAlex, Crossref.
Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).
Semantic Scholar’s data is described in: Kinney, R., et al. (2023). The Semantic Scholar Open Data Platform. arXiv:2301.10140.
