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Cited by 505

The DOI matches its Crossref record; 10 of the 10 references it cites were found in a registry or an index.

Antigenic variation in Plasmodium falciparum.

Open access
Biggs, B A, Goozé, L, Wycherley, K, Wollish, W, Southwell, B, Leech, J H, Brown, G V·1991·Proceedings of the National Academy of Sciences

Abstract

Antigenic variation of infectious organisms is a major factor in evasion of the host immune response. However, there has been no definitive demonstration of this phenomenon in the malaria parasite Plasmodium falciparum. In this study, cloned parasites were examined serologically and biochemically for the expression of erythrocyte surface antigens. A cloned line of P. falciparum gave rise to progeny that expressed antigenically distinct forms of an erythrocyte surface antigen but were otherwise identical. This demonstrates that antigenic differences on the surface of P. falciparum-infected erythrocytes can arise by antigenic variation of clonal parasite populations. The antigenic differences were shown to result from antigenic variation of the parasite-encoded protein, the P. falciparum erythrocyte membrane protein 1.

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Metadata

Authors
Biggs, B. A., Goozé, L., Wycherley, K., Wollish, W., Southwell, B., Leech, J. H., & Brown, G. V.
Venue
Proceedings of the National Academy of Sciences
Published
1991-10-15
Volume
88
Issue
20
Pages
9171-9174
ISSN
  • 0027-8424 (ISSN-L)
  • 1091-6490
OpenAlex
W2094649888
Cited by
505
References
10
FWCI
9.25
Type
journal article
Language
en
Open access
green

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CoChat. (2026). Citation check: Antigenic variation in Plasmodium falciparum. https://app.cochat.ai/papers/10.1073/pnas.88.20.9171
The paper
Biggs, B. A., Goozé, L., Wycherley, K., Wollish, W., Southwell, B., Leech, J. H., & Brown, G. V. (1991). Antigenic variation in Plasmodium falciparum. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.20.9171

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Contains information from the Semantic Scholar Academic Graph Datasets, made available under the ODC Attribution License (ODC-BY 1.0).

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