The DOI matches its Crossref record; 53 of the 53 references it cites were found in a registry or an index.
An Epigenetic Signature for Monoallelic Olfactory Receptor Expression
Open accessAbstract
SUMMARY Constitutive heterochromatin is traditionally viewed as the static form of heterochromatin that silences pericentromeric and telomeric repeats in a cell cycle and differentiation independent manner. Here, we show that in the mouse olfactory epithelium, olfactory receptor (OR) genes are marked, in a highly dynamic fashion, with the molecular hallmarks of constitutive heterochromatin, H3K9me3 and H4K20me3. The cell-type and developmentally dependent deposition of these marks along the OR clusters is, most likely, reversed during the process of OR choice to allow for monogenic and monoallelic OR expression. In contrast to the current view of OR choice, our data suggest that OR silencing takes place before OR expression, indicating that it is not the product of an OR-elicited feedback signal. This suggests a new role for chromatin-mediated silencing as the molecular foundation upon which singular and stochastic selection can be applied.
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Metadata
- Authors
- Magklara, A., Yen, A., Colquitt, B. M., Clowney, E. J., Allen, W., Markenscoff-Papadimitriou, E., Evans, Z. A., Kheradpour, P., Mountoufaris, G., Carey, C., Barnea, G., Kellis, M., & Lomvardas, S.
- Venue
- Cell
- Publisher
- Elsevier BV
- Published
- 2011-05
- Volume
- 145
- Issue
- 4
- Pages
- 555-570
- ISSN
- 0092-8674 (ISSN-L)
- OpenAlex
- W2104171953
- Cited by
- 305
- References
- 53
- FWCI
- 11.76
- Type
- journal article
- Language
- en
- Open access
- bronze
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- Magklara, A., Yen, A., Colquitt, B. M., Clowney, E. J., Allen, W., Markenscoff-Papadimitriou, E., Evans, Z. A., Kheradpour, P., Mountoufaris, G., Carey, C., Barnea, G., Kellis, M., & Lomvardas, S. (2011). An Epigenetic Signature for Monoallelic Olfactory Receptor Expression. Cell. https://doi.org/10.1016/j.cell.2011.03.040
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