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Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes.
Open accessAbstract
Three genes closely related to the D1 dopamine receptor were identified in the human genome. One of the genes lacks introns and encodes a functional human dopamine receptor, D5, whose deduced amino acid sequence is 49% identical to that of the human D1 receptor. Compared with the human D1 dopamine receptor, the D5 receptor displayed a higher affinity for dopamine and was able to stimulate a biphasic rather than a monophasic intracellular accumulation of cAMP. Neither of the other two genes was able to direct the synthesis of a receptor. Nucleotide sequence analysis revealed that these two genes are 98% identical to each other and 95% identical to the D5 sequence. Relative to the D5 sequence, both contain insertions and deletions that result in several in-frame termination codons. Premature termination of translation is the most likely explanation for the failure of these genes to produce receptors in COS-7 and 293 cells even though their messages are transcribed. We conclude that the two are pseudogenes. Blot hybridization experiments performed on rat genomic DNA suggest that there is one D5 gene in this species and that the pseudogenes may be the result of a relatively recent evolutionary event.
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Cited by
Dopamine receptors: from structure to function
MISSALE, C., NASH, S. R., ROBINSON, S. W., JABER, M., & CARON, M. G. (1998) · Physiological Reviews · doi:10.1152/physrev.1998.78.1.189 · Cited by 3,633
The physiology, signaling, and pharmacology of dopamine receptors
Beaulieu, J.-M., & Gainetdinov, R. R. (2011) · Pharmacological Reviews · doi:10.1124/pr.110.002642 · Cited by 2,763
The principal features and mechanisms of dopamine modulation in the prefrontal cortex
Seamans, J. K., & Yang, C. R. (2004) · Progress in Neurobiology · doi:10.1016/j.pneurobio.2004.05.006 · Cited by 1,592
Molecular Diversity of the Dopamine Receptors
Civelli, O., Bunzow, J. R., & Grandy, D. K. (1993) · Annual Review of Pharmacology and Toxicology · doi:10.1146/annurev.pa.33.040193.001433 · Cited by 623
Self-citationThe dopamine D4 receptor: one decade of research
Oak, J. N., Oldenhof, J., & Van Tol, H. H. M. (2000) · European Journal of Pharmacology · doi:10.1016/s0014-2999(00)00562-8 · Cited by 419
Metadata
- Authors
- Grandy, D. K., Zhang, Y. A., Bouvier, C., Zhou, Q. Y., Johnson, R. A., Allen, L., Buck, K., Bunzow, J. R., Salon, J., & Civelli, O.
- Venue
- Proceedings of the National Academy of Sciences
- Published
- 1991-10-15
- Volume
- 88
- Issue
- 20
- Pages
- 9175-9179
- ISSN
- 0027-8424 (ISSN-L)
- 1091-6490
- OpenAlex
- W1979027736
- Cited by
- 209
- References
- 0
- FWCI
- 6.22
- Type
- journal article
- Language
- en
- Open access
- green
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- Grandy, D. K., Zhang, Y. A., Bouvier, C., Zhou, Q. Y., Johnson, R. A., Allen, L., Buck, K., Bunzow, J. R., Salon, J., & Civelli, O. (1991). Multiple human D5 dopamine receptor genes: a functional receptor and two pseudogenes. Proceedings of the National Academy of Sciences. https://doi.org/10.1073/pnas.88.20.9175
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